2-(2,4-Difluorophenyl)-5-fluoropyridine

CAS Number 1426047-01-9

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

2-(2,4-Difluorophenyl)-5-fluoropyridine MSDS

2-(2,4-Difluorophenyl)-5-fluoropyridine CAS 1426047-01-9

A difluorinated heterocyclic ligand

Also a well-known chelating ligand in application of APIs, OLEDs, DSSCs and photocatalytic reactions

Overview
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2-(2,4-Difluorophenyl)-5-fluoropyridine (DFFPPy), CAS number 1426047-01-9, normally serving as a chelating ligand, is a trifluorinated phenyl-pyridine derivative. Phenyl-pyridine building blocks are popular candidates in the synthesis of iridium complexes for catalytic photoredox reactions, assisting the formation of Ir(III)* (excited triplet state) upon visible light irradiation. 2-(2,4-Difluorophenyl)-5-fluoropyridine also shows its effectiveness for visceral leishmaniasis in preclinical screening assay. The increase lipophilicity brought by the fluorine substituents has higher potency against Leishmania infantum.

As a cyclometalating ligand used for photoemitter and being electron deficient with the help of three fluorine, DFFPPy introduces blue shift to the emission wavelength (typically by reducing the highest occupied molecular orbital energy level) and increases the photoluminescence quantum yield (from 6.5% to 50.8%).

Multiple functional groups

For facile synthesis

Fluorinated phenylpyridine building block

For drug discoveries, solar cells, and photocatalists

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	1426047-01-9
Chemical Formula	C₁₂H₆F₃N
Full Name	2-(2,4-Difluorophenyl)-5-fluoropyridine
Molecular Weight	209.17 g/mol
Synonyms	DFFPPy
Classification / Family	Pyridine derivatives, Fluorinated building blocks, Heterocyclic building block, Dyes, DSSCs, Photocatalyst ligands, OLEDs

Chemical Structure

Product Details

Purity	>98%
Melting Point	T_m = 75 °C – 78 °C
Appearance	White to yellow powder/crystal

MSDS Documentation

2-(2,4-Difluorophenyl)-5-fluoropyridine MSDS Sheet

Literature and Reviews

7-Substituted 2-nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: novel antitubercular agents lead to a new preclinical candidate for visceral leishmaniasis, A. Tompson et al., J. Med. Chem., 60, 4212−4233(2017); DOI: 10.1021/acs.jmedchem.7b00034.
A radical approach to the copper oxidative addition problem: trifluoromethylation of bromoarenes, C. Le et al., Science, 360(6392), 1010-1014(2018), DOI: 10.1126/science.aat4133.
Developments in photoredox-mediated alkylation for DNA-encoded libraries, S. Patel et al., Trends Chem., 3(3), 161-175(2021); DOI: 10.1016/j.trechm.2020.11.010.
Highly efficient phosphorescence from cyclometallated iridium(III) compounds: improved syntheses of picolinate complexes and quantum chemical studies of their electronic structures, R. Sanner et al., Inorganica Chim. Acta, 496, 119040(2019); DOI: 10.1016/j.ica.2019.119040.
Effects of fluorine substituent on properties of cyclometalated iridium(III) complexes with a 2,2′-bipyridine ancillary ligand, Tetrahedon, 75(47), 130686(2019); DOI: 10.1016/j.tet.2019.130686.

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