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Product Code B1921-LT-500mg
Price £105 ex. VAT

A difluorinated heterocyclic ligand

Also a well-known chelating ligand in application of APIs, OLEDs, DSSCs and photocatalytic reactions

Specifications | MSDS | Literature and Reviews

2-(2,4-Difluorophenyl)-5-fluoropyridine (DFFPPy), CAS number 1426047-01-9, normally serving as a chelating ligand, is a trifluorinated phenyl-pyridine derivative. Phenyl-pyridine building blocks are popular candidates in the synthesis of iridium complexes for catalytic photoredox reactions, assisting the formation of Ir(III)* (excited triplet state) upon visible light irradiation. 2-(2,4-Difluorophenyl)-5-fluoropyridine also shows its effectiveness for visceral leishmaniasis in preclinical screening assay. The increase lipophilicity brought by the fluorine substituents has higher potency against Leishmania infantum.

As a cyclometalating ligand used for photoemitter and being electron deficient with the help of three fluorine, DFFPPy introduces blue shift to the emission wavelength (typically by reducing the highest occupied molecular orbital energy level) and increases the photoluminescence quantum yield (from 6.5% to 50.8%).

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated phenylpyridine building block

For drug discoveries, solar cells, and photocatalists

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High purity 1426047-01-9

High purity

>98% High purity

General Information

CAS Number 1426047-01-9
Chemical Formula C12H6F3N
Full Name 2-(2,4-Difluorophenyl)-5-fluoropyridine
Molecular Weight 209.17 g/mol
Synonyms DFFPPy
Classification / Family Pyridine derivatives, Fluorinated building blocks, Heterocyclic building block, Dyes, DSSCs, Photocatalyst ligands, OLEDs

Chemical Structure

2-(2,4-Difluorophenyl)-5-fluoropyridine chemical structure, CAS 1426047-01-9
2-(2,4-Difluorophenyl)-5-fluoropyridine chemical structure, CAS 1426047-01-9

Product Details

Purity >98%
Melting Point Tm = 75 °C – 78 °C
Appearance White to yellow powder/crystal

MSDS Documentation

2-(2,4-Difluorophenyl)-5-fluoropyridine2-(2,4-Difluorophenyl)-5-fluoropyridine MSDS Sheet

Literature and Reviews

  1. 7-Substituted 2-nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: novel antitubercular agents lead to a new preclinical candidate for visceral leishmaniasis, A. Tompson et al., J. Med. Chem., 60, 4212−4233(2017); DOI: 10.1021/acs.jmedchem.7b00034.
  2. A radical approach to the copper oxidative addition problem: trifluoromethylation of bromoarenes, C. Le et al., Science, 360(6392), 1010-1014(2018), DOI: 10.1126/science.aat4133.
  3. Developments in photoredox-mediated alkylation for DNA-encoded libraries, S. Patel et al., Trends Chem., 3(3), 161-175(2021); DOI: 10.1016/j.trechm.2020.11.010.
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