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3-Fluoro-p-anisidine

CAS Number 366-99-4

Fluorinated Building Blocks, Monomers


Product Code B2641-10g
Price $113 ex. VAT

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A fluorinated p-anisidine building block

Used as a precursor for heterocycles in application of APIs


3-Fluoro-p-anisidine (CAS number 366-99-4), also referred to as 3-fluoro-4-methoxyaniline, is an aniline with a fluoride and a methoxy substituted at 3- and 4-positions. 3-Fluoro-p-anisidine is commonly used as a precursor for synthesising quinoline derivatives through Combes quinoline synthesis with 1,3-diketones. The as synthesised quinoline derivatives are employed as active pharmaceutical ingredients and dyes. 3-Fluoro-p-anisidine is readily attached to molecular scaffolds through nucleophilic substitution.

The primary amine in 3-fluoro-p-anisidine can be used to prepare azides for copper-catalysed azide-alkyne cycloaddition (click reaction).

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated aniline building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 366-99-4

High purity

>97% High purity

General Information

CAS Number 366-99-4
Chemical Formula C7H8FNO
Full Name 3-Fluoro-4-methoxyaniline
Molecular Weight 141.15 g/mol
Synonyms 4-Amino-2-fluoroanisole, 3-Fluoro-4-methoxyaniline, 4-Amino-2-fluoro-1-methoxybenzene
Classification / Family Fluorinated building blocks, Aniline building blocks, APIs, Heterocycles

Chemical Structure

3-Fluoro-p-anisidine chemical structure, CAS 366-99-4.
3-Fluoro-p-anisidine chemical structure, CAS 366-99-4

Product Details

Purity 97%
Melting Point Tm = 81 °C – 83 °C
Appearance Brown powder

MSDS Documentation

3-Fluoro-p-anisidine 3-Fluoro-p-anisidine MSDS Sheet

Literature and Reviews

  1. 7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases, D. Boschelli et al., J. Med. Chem., 47(7), 1599–1601(2004); DOI: 10.1021/jm0499458.
  2. CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents, C.-M. Peng et al., RSC Adv., 13, 13169(2023); DOI: 10.1039/d3ra01927f.
  3. Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells, W. Zhao et al., Sci. Rep., 5, 17175(2015); DOI: 10.1038/srep17175.
  4. Synthesis and dual PPARa/d agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516, C. Ciocoiu et al., Eur. J. Med. Chem., 45, 3047–3055(2010); DOI: 10.1016/j.ejmech.2010.03.035.
  5. Synthesis, biodistribution and micro-PET imaging of radiolabelled antimitotic agent T138067 analogues, X. Fei et al., Bio. Med. Chem. Lett., 14, 1247–1251(2004); DOI: 10.1016/j.bmcl.2003.12.061.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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