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2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

CAS Number 82671-02-1

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers


Product Code B2541-25g
Price £90 ex. VAT

A halogenated pyridinecarbonitrile

Used as a synthetic precursor for APIs


Specifications | MSDS | Literature and Reviews


2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile (CAS number 82671-02-1), also referred to as 2,6-dichloro-3-cyano-5-fluoropyridine, is derived from pyridine with two chlorides, a fluoride and a nitrile substituents. The most recognised reaction using 2,6-dichloro-5-fluoro-3-pyridinecarbonitrile is the synthesis of Gemifloxacin, an oral broad-spectrum antibiotic. Other than Gemifloxacin, 2,6-dichloro-5-fluoro-3-pyridinecarbonitrile is also a molecular scaffold for 1,8-naphthyridine derivatives including Enoxacin, Trovafloxacin and Tosufloxacin. 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile enables facile synthesis of a wide range of fluoroquinolone derivatives with different building blocks for reducing the side effects of medication and expanding the medical applications.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated nicotinonitrile building block

For organic synthesis, medicinal chemistry and biochemistry research

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High purity 82671-02-01

High purity

>98% High purity

General Information


CAS Number 82671-02-1
Chemical Formula C6HCl2FN2
Full Name 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile
Molecular Weight 190.99 g/mol
Synonyms 2,6-Dichloro-3-cyano-5-fluoropyridine, 2,6-Dichloro-5-fluoro-3-nicotinonitrile, 2,6-Dichloro-5-fluoronicotinonitrile
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, APIs, Antibiotics, Bicyclic compounds

Chemical Structure


2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile chemical structure, CAS 82671-02-1.
2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile chemical structure, CAS 82671-02-1

Product Details


Purity 98%
Melting Point Tm = 89 °C – 91 °C
Appearance White powder

MSDS Documentation


2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile MSDS Sheet

Literature and Reviews


  1. Novel fluoroquinolone antibacterial agents containing oxime-substituted (aminomethyl)pyrrolidines: synthesis and antibacterial activity of 7-(4-(aminomethyl)-3-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6- fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid (LB20304), C. Hong et al., J. Med. Chem., 40(22), 3584–3593(1997); DOI: 10.1021/jm970202e.
  2. Synthesis and in vitro antibacterial activity of Gemifloxacin derivatives containing a substituted benzyloxime moiety, L. Feng et al., Eur. J. Med. Chem., 55, 125–136(2012); DOI: 10.1016/j.ejmech.2012.07.010.
  3. Synthesis, spectroscopic, and biological studies of mixed ligand complexes of Gemifloxacin and glycine with Zn(II), Sn(II), and Ce(III), Molecules, 23, 1182(2018); DOI: 10.3390/molecules23051182.
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