3,4,5-Trifluoroaniline

CAS Number 163733-96-8

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers

Fluorinated aniline building block

For synthesizing APIs and perovskites for OLEDs

Overview
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3,4,5-Trifluoroaniline (CAS number 163733-96-8) is an aniline building block with three fluorine atoms at 3-, 4-, and 5-positoins. 3,4,5-Trifluoroaniline is often used as an electron deficient aniline for substrate scope study in organic synthesis. Organic colour centres can be produced by 3,4,5-trifluoroaniline functionalised single wall carbon nanotubes (SWCNTs), generating distinct fluorescence bands at longer wavelengths from the emission of SWCNTs (E₁₁). The functionalisation of SWCNTs is performed in one pot with 3,4,5-trifluoroaniline, SWCNTs, sodium nitrite and chlorosulfonic acid. A capsid assembly modulator that inhibits the replication of hepatitis B virus is synthesised from 3,4,5-trifluoroaniline.

A quasi-2D perovskite film consisting of lead bromide and 3,4,5-trifluoroaniline displays the maximum luminance of 1.2 × 10³ cd/m² and current efficiency up to 0.3 cd/A.

Multiple functional groups

For facile synthesis

Fluorinated aniline building block

For drug discovery, organic synthesis and OLEDs research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	163733-96-8
Chemical Formula	C₆H₄F₃N
Full Name	3,4,5-Trifluoroaniline
Molecular Weight	147.10 g/mol
Synonyms	3,4,5-Trifluorobenzenamine
Classification / Family	Fluorinated building block, APIs, Ligands, OLEDs

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 61 °C – 64 °C
Appearance	Grey/purple crystals

MSDS Documentation

3,4,5-Trifluoroaniline MSDS Sheet

Literature and Reviews

Ruthenium-catalysed N-alkylation of anilines with primary carbohydrate alcohols via borrowing hydrogen strategy, K. Tsuge et al., Chem. Commun., 59, 7052(2023); DOI: 10.1039/d3cc01931d.
Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning, M. Kim et al., Nat. Biomed. Eng., 6, 267–275(2022); DOi: 10.1038/s41551-022-00860-y.
Discovery of a new sulfonamide hepatitis B capsid assembly modulator, H. Na et al., ACS Med. Chem. Lett., 11, 166–171(2022); DOI: 10.1021/acsmedchemlett.9b00550.
Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection, S. Khushbu et al., Bioorg. Med. Chem. Lett., 29(15), 1874–1880(2019); Doi: 10.1016/j.bmcl.2019.06.004.
Super air stable quasi-2D organic-inorganic hybrid perovskites for visible light-emitting diodes, G. Jia et al., Opt. Express, 26(2), 66–74(2018); DOI: 10.1364/OE.26.000A66.

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