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CAS Number 163733-96-8

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers

Product Code B2481-5g
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Fluorinated aniline building block

For synthesizing APIs and perovskites for OLEDs

3,4,5-Trifluoroaniline (CAS number 163733-96-8) is an aniline building block with three fluorine atoms at 3-, 4-, and 5-positoins. 3,4,5-Trifluoroaniline is often used as an electron deficient aniline for substrate scope study in organic synthesis. Organic colour centres can be produced by 3,4,5-trifluoroaniline functionalised single wall carbon nanotubes (SWCNTs), generating distinct fluorescence bands at longer wavelengths from the emission of SWCNTs (E11). The functionalisation of SWCNTs is performed in one pot with 3,4,5-trifluoroaniline, SWCNTs, sodium nitrite and chlorosulfonic acid. A capsid assembly modulator that inhibits the replication of hepatitis B virus is synthesised from 3,4,5-trifluoroaniline.

A quasi-2D perovskite film consisting of lead bromide and 3,4,5-trifluoroaniline displays the maximum luminance of 1.2 × 103 cd/m2 and current efficiency up to 0.3 cd/A.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated aniline building block

For drug discovery, organic synthesis and OLEDs research

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High purity 163733-96-8

High purity

>98% High purity

General Information

CAS Number 163733-96-8
Chemical Formula C6H4F3N
Full Name 3,4,5-Trifluoroaniline
Molecular Weight 147.10 g/mol
Synonyms 3,4,5-Trifluorobenzenamine
Classification / Family Fluorinated building block, APIs, Ligands, OLEDs

Chemical Structure

3,4,5-Trifluoroaniline chemical structure, CAS 163733-96-8.
3,4,5-Trifluoroaniline chemical structure, CAS 163733-96-8

Product Details

Purity 98%
Melting Point Tm = 61 °C – 64 °C
Appearance Grey/purple crystals

MSDS Documentation

3,4,5-Trifluoroaniline3,4,5-Trifluoroaniline MSDS Sheet

Literature and Reviews

  1. Ruthenium-catalysed N-alkylation of anilines with primary carbohydrate alcohols via borrowing hydrogen strategy, K. Tsuge et al., Chem. Commun., 59, 7052(2023); DOI: 10.1039/d3cc01931d.
  2. Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning, M. Kim et al., Nat. Biomed. Eng., 6, 267–275(2022); DOi: 10.1038/s41551-022-00860-y.
  3. Discovery of a new sulfonamide hepatitis B capsid assembly modulator, H. Na et al., ACS Med. Chem. Lett., 11, 166–171(2022); DOI: 10.1021/acsmedchemlett.9b00550.
  4. Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection, S. Khushbu et al., Bioorg. Med. Chem. Lett., 29(15), 1874–1880(2019); Doi: 10.1016/j.bmcl.2019.06.004.
  5. Super air stable quasi-2D organic-inorganic hybrid perovskites for visible light-emitting diodes, G. Jia et al., Opt. Express, 26(2), 66–74(2018); DOI: 10.1364/OE.26.000A66.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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