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Product Code B2581-2g
Price £70 ex. VAT

A fluorinated phenylacetic acid building block

Used as a difluoromethylation reagent for pharmaceutical and agrochemical ingredients

Specifications | MSDS | Literature and Reviews

α,α-Difluorophenylacetic acid (CAS number 360-03-2) is a phenyl acetic acid with two fluorides on the benzylic carbon. The inductive effect of the difluoromethyl group increases the acidity of α,α-difluorophenylacetic acid. α,α-Difluorophenylacetic acid is primarily used to introduce benzylic difluoromethylene group to molecular scaffolds through radical decarboxylative reaction. The reaction begins with an oxidative decarboxylation with persulfate forming a difluorobenzyl radical that is stabilised by the benzene and fluorine groups. The addition is carried out by the attack of the radical species to the alkenes or imines. The decarboxylative reaction is versatile and can even be performed in an aqueous solution.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated phenylacetic acid building block

For organic synthesis, medicinal chemistry and biochemistry research

Worldwide shipping for 360-03-2

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High purity 360-03-2

High purity

>98% High purity

General Information

CAS Number 360-03-2
Chemical Formula C8H6F2O2
Full Name α,α-Difluorophenylacetic acid
Molecular Weight 172.13 g/mol
Synonyms 2,2-Difluoro-2-phenylacetic acid
Classification / Family Fluorinated building block, Decarboxylative reactions, APIs

Chemical Structure

α,α-Difluorophenylacetic acid chemical structure, CAS 360-03-2.
α,α-Difluorophenylacetic acid chemical structure, CAS 360-03-2

Product Details

Purity 98%
Melting Point Tm = 65 °C – 75 °C
Appearance White crystals

MSDS Documentation

α,α-Difluorophenylacetic acidα,α-Difluorophenylacetic acid MSDS Sheet

Literature and Reviews

  1. Photoinitiated decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1H)-ones with potassium 2,2-difluoro-2-arylacetates in water, Y. Gao et al., RSC Adv., 10, 10559(2020); DOI: 10.1039/d0ra02059a.
  2. Insight into the mechanism of phenylacetate decarboxylase (PhdB), a toluene-producing glycyl radical enzyme, A. Rodrigues et al., ChemBioChem, 21, 663–671(2020); DOI: 10.1002/cbic.201900560.
  3. Synthesis of difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones under mild conditions, K. Sui et al., ACS Omega, 8, 7517–7528(2023); DOI: 10.1021/acsomega.2c06689.

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