2-(2,4-Difluorophenyl)-5-methylpyridine

CAS Number 583052-21-5

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

2-(2,4-Difluorophenyl)-5-methylpyridine MSDS

2-(2,4-Difluorophenyl)-5-methylpyridine CAS 583052-21-5

A difluorinated heterocyclic building block

As cyclometalating ligand to form coordinative complexes in application of OLEDs, DSSCs and photocatalysis reactions

Overview
Related Products

2-(2,4-Difluorophenyl)-5-methylpyridine (DFPMPy), CAS number 583052-21-5, is a difluorinated heterocyclic derivative of arylpyridine with enhanced solubility by the methyl group. DFPMPy is often used as a cyclometalating ligand with the nitrogen electron lone pair and the delocalized π-electron cloud in the benzene ring being coordinated to a metal centre. The metal-ligand complexes have demonstrated excellent photocatalytic capability in visible-light photoredox reactions. During the photoredox process, an electron migrates from the metal centre to the ligands, also known as metal-ligand charge transfer (MLCT) after irradiation as the complex reaches the excited state. After the single-electron transfer, the excited complex regains an electron from another reagent and restart the photoredox catalytic cycle.

These complexes are also synthesized for light-emitting electrochemical cells with photoluminescent quantum yield up to 93%. The fluorine-substituents lower the highest occupied molecular orbital (HOMO) energy level resulting shifts in the emission spectrum. Arylpyridine-iridium complexes are widely investigated in water splitting to generate hydrogen. As photosensitizers, these complexes are also used in dye-sensitized solar cells (DSSCs).

Multiple functional groups

For facile synthesis

Fluorinated phenylpyridine building block

For drug discoveries, solar cells, and photocatalists

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	583052-21-5
Chemical Formula	C₁₂H₉F₂N
Full Name	2-(2,4-Difluorophenyl)-5-methylpyridine
Molecular Weight	205.21 g/mol
Synonyms	DFPMPy
Classification / Family	Pyridine derivatives, Fluorinated building blocks, Heterocyclic building block, Dyes, DSSCs, Photocatalyst ligands, OLEDs

Chemical Structure

Product Details

Purity	>97%
Melting Point	T_m = 55 °C
Appearance	White/off-white to yellow to light brown powder/crystal

MSDS Documentation

2-(2,4-Difluorophenyl)-5-methylpyridine MSDS Sheet

Literature and Reviews

Visible light driven generation and alkyne insertion reactions of stable bis-cyclometalated Pt(IV) hydrides, D. Poveda et al., Chem. Sci., 11, 12095–12102(2020); DOI: 10.1039/d0sc04879h.
Cationic iridium (III) complexes bearing ancillary 2,5-dipyridyl(pyrazine) (2,5-dpp) and 2,2’:5’,2’’- terpyridine (2,5-tpy) ligands: synthesis, optoelectronic characterization and light-emitting electrochemical cells, K. Hasan et al.,
Dalton Trans., 43, 13672-13682(2014); DOI: 10.1039/C4DT02100B.
Generation of phosphoranyl radicals via photoredox catalysis enables voltage−independent activation of strong C−O bonds, E. Stache et al., ACS Catal., 8(12), 11134–11139(2018); DOI: 10.1021/acscatal.8b03592.
Intimate electronic coupling in cationic homodimeric iridium(III) complexes, A. Soliman et al., Dalton Trans., 41, 9382(2012); DOI: 10.1039/c2dt30836c.
Merging photoredox and nickel catalysis: decarboxylative cross-coupling of carboxylic acid with vinyl halides, A. Noble et al., J. Am. Chem. Soc., 137, 624-627(2015); DOI: 10.1021/ja511913h.
Recent advances in synthesis of molecular heteroleptic osmium and iridium phosphorescent emitters, M. Buil et al., Eur. J. Inorg. Chem., 2021(46), 4731–4761(2021); DOI: 10.1002/ejic.202100663.
Intermolecular crossed [2+2] cycloaddition promoted by visible-light triplet photosensitization: expedient access to polysubstituted 2-oxaspiro[3.3]heptanes, P. Murray et al., J. Am. Chem. Soc., 143(10), 4055–4063(2021); DOI:10.1021/jacs.1c01173.
The transformation and storage of solar energy: progress towards visible-light induced water splitting, E. Cline et al., Chimia, 63, 709-713(2009); DOI: 10.2533/chimia.2008.709.
Tuning the emission of cationic iridium(III) complexes towards the red through methoxy substitution of the cyclometalating ligand, K. Hasan et al., Sci. Rep., 5, 12325(2015); DOI: 10.1038/srep12325.

Related Products

We stock a wide range of monomers available to purchase online. Please contact us if you cannot find what you are looking for.

BDD

From £240

Benzodithiophene-2THBr-4EH

From £440

BDTOEHSn

From £220

BDTT

From £370

BDTT-F-Sn

From £500

BDTT-Cl-Sn

From £440

BDT-Th(TPS)-Sn

From £300

D18-2Br

From £400

2-Ethylhexyl 4,6-dibromo-3-fluorothieno[3,4-b]thiophene-2-carboxylate

From £260

TPD-C8

Price £155

2,1,3-Benzothiadiazole-4,7-bis(boronic acid pinacol ester)

From £105

2,2'-bithiophene

From £64

2,2'-bithiophene-5-carbonitrile

Price £330

2,5-bis(trimethylstannyl)-thieno[3,2-b]thiophene

From £180

5,5'-bis(trimethylstannyl)-2,2'-bithiophene

From £180

3,3'-Difluoro-5,5'-bis(trimethylstannyl)-2,2'-bithiophene

From £280

2,6-dibromo-4,4-bis(2-ethylhexyl)-4H-cyclopenta[1,2-b:5,4-b']dithiophene

From £260

CDT-EH-Sn

From £400

DTS-EH-Sn

From £400

2,7-Dibromo-9,9-bis[3,3'-(N,N-dimethylamino)-propyl]fluorene

From £170

2,7-Dibromocarbazole

From £60

2-Bromotriphenylene

From £130

2ClIC

From £360

2FIC

From £360

3,6-bis(5-bromothiophen-2-yl)-2,5-bis(2-octyldodecyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione

From £260

2HIC, 3-(Dicyanomethylidene)indan-1-one

From £310

3-Hexylthiophene

Price £180

PCE11 Monomer

From £480

BBT-2C6ThBr

From £330

Bromothiophene Benzothiadiazole

From £155

4,7-Dibromo-2,1,3-benzothiadiazole

From £72

4,7-Dibromo-5,6-difluoro-2,1,3-benzothiadiazole

From £210

4H-Cyclopenta[1,2-b:5,4-b']dithiophene

From £170

9,9-Dioctyl-2,7-dibromofluorene

Price £80

2,2'-(9,9-dioctyl-9H-fluorene-2,7-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

Price £210

9-(heptadecan-9-yl)-2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole

From £220

Benzo[1,2-b:4,5-b']dithiophene-4,8-dione

From £200

BPPTRZ-2Cl

From £130

DFBTA-2ThBr-HD

From £310

DPP-BO-2ThBr

Price £250

DPP-EH-2ThBr

From £250

DPP-HD-2ThBr

From £250

DPPDPy2Br

From £210

EHOThCHO-Br

From £330

EHThCHO-Br

From £200

ICz-Br

From £180

IDTB6-2CHO

From £300

IDTTB6-2CHO

From £380

NDI-2HD-2Br

From £350

NDI-2OD-2Br

From £350

PTRZ-2Cl

From £160

Quinoxaline-2PhO-2Br

Price £370

Thienothiophene, Thieno[3,2-b]thiophene

From £64

Thieno[3,2-b]thiophene-2-carbonitrile

From £130

TTP-TTI-2CHO

From £660

Ethyl 2,5-dibromothiophene-3-carboxylate

From £130

2,5-Dibromo-3-chlorothiophene

From £130

MeHDOQx-DBrDF

From £520

HDOQx-DBrDF

From £520

BT-C14-2Br

From £250

FIC

From £220

Br-BT-CHO

From £200

ClIC

From £220

BrIC

From £220

IDTB6-2Sn

From £350

IDTB6-2Br

From £350

IDTTB6-2Br

From £400

IDTTB6-2Sn

From £260

BT-C12-2Br

From £170

BT-HD-2Br

From £300

DTT, Dithieno[3,2-b:2′,3′-d]thiophene

From £220

5,5'-Dibromo-2,2'-bithiophene

From £76

3,3'-Dibromo-2,2'-bithiophene

From £170

3,6-Dibromothieno[3,2-b]thiophene (TT36)

From £240

3TCN-HD-2Br

From £370

2,3,5,6-Tetrabromothieno[3,2-b]thiophene

From £100

3,3′,5,5′-Tetrabromo-2,2′-bithiophene

From £145

5,5′′-Dibromo-2,2′:5′,2′′-terthiophene

From £120

2,2′:5′,2′′-Terthiophene

From £185

2,6-Dibromodithieno[3,2-b:2′,3′-d]thiophene

From £185

3,4-(2,2-Dimethylpropylenedioxy)thiophene

From £190

2,7-Dibromophenanthrene-9,10-dione

From £170

9,9′-Spirobifluorene

From £155

2,2′,7,7′-Tetrabromo-9,9′-spirobifluorene

From £185

2,7-Dibromo-9,9′-spirobifluorene

From £185

3,7-Dibromodibenzothiophene 5,5-dioxide

From £180

2,8-Dibromodibenzothiophene

From £210

6,6′-Dibromoisoindigo

From £125

2,5-Dihydro-3,6-di-2-thienyl-pyrrolo[3,4-c]pyrrole-1,4-dione

From £210

6,9-bis(5-bromo-4-(2-butyloctyl)thiophen-2-yl)dithieno[3,2-f:2',3'-h]quinoxaline

From £300

N,N-Bis(4-bromophenyl)-2,4,6-trimethylaniline

From £140

5,5'-Dibromo-3,3'-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2,2'-bithiophene

From £240

3,6-Di-tert-butylcarbazole

From £105

3,6-Diphenylcarbazole

From £105

Indolo[3,2-b]carbazole

From £160

10,15-Dihydro-5H-diindolo[3,2-a:3',2'-c]carbazole

From £175

2-Bromo-9H-carbazole

From £170

3-Bromo-9H-carbazole

From £145

1,4-Dibromonaphthalene

From £195

2-Bromonaphthalene

From £80

2-Bromodibenzothiophene

From £115

1,5-Dibromonaphthalene

From £85

2-Decylthiophene

From £230

2,3-Dibromonaphthalene

From £90

2-Dodecylthiophene

From £230

1,8-Dibromonaphthalene

From £120

Tetrabromothiophene

From £130

9,10-Dibromoanthracene

From £105

2,7-Dibromonaphthalene

From £150

9-Bromoanthracene

From £80

2,6-Dibromonaphthalene

From £185

2-Bromo-6-fluoronaphthalene

From £130

2-Bromoanthracene

From £200

SA4, Volatile Solid Additive, DIO Replacement

From £210

2,5-Dibromo-3,4-dinitrothiophene

From £130

4,4'-Dibromo-2,2'-bipyridine

From £200

4,4'-Dibromo-2,2'-dinitrobiphenyl

From £200

5,5'-dibromo-3,3'-difluoro-2,2'-bithiophene

From £250

2,2′-Bipyridine-4,4′-dicarboxylic acid

£175
From £175

2,6-Dihydroxyanthraquinone

From £140

4,4'-Dimethyl-2,2'-bipyridyl

From £72

2,2′-Bipyridine-5,5′-dicarboxylic acid

£110
From £110

5,5'-Bis(trifluoromethyl)-2,2'-bipyridine

From £210

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

From £115

4-Fluoro-1H-indazole

From £72

2,6-Dibromoanthraquinone

From £110

5,5'-Dimethyl-2,2'-bipyridine

From £110

2-Bromo-5-decylthiophene

From £115

4-(Trifluoromethyl)-2-pyridone

From £72

2-Bromo-5-dodecylthiophene

From £76

5,5'-Dibromo-2,2'-bipyridine

From £115

5,5'-Dibromo-4,4'-dihexyl-2,2'-bithiophene

From £280

3,3-Difluoroazetidine hydrochloride

Price £170

2-(Difluoromethyl)benzimidazole

From £115

Indolo[2,3-a]carbazole

From £145

3,3'-Bicarbazole

From £200

6-Fluoro-4-chromanone

From £120

2,4,6-Trimethyl-N,N-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)aniline

From £190

5-Bromo-3-fluorosalicylaldehyde

From £110

4-Butyl-N,N-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-4-phenyl)aniline

From £200

Ethyl (4-fluorobenzoyl)acetate

From £110

2,4,6-Trifluoronitrobenzene

From £74

(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone

From £145

8-Fluoro-4-hydroxy-2-methylquinoline

From £95

6-Chloro-8-fluoroquinoline

From £80

4-Bromo-8-fluoroquinoline

From £135

4-Chloro-7-trifluoromethylquinoline-3-carboxylic acid ethyl ester

From £145

2-(2,4-Difluorophenyl)-5-fluoropyridine

From £105

3,3',4,4'-Benzophenonetetracarboxylic dianhydride (BTDA)

£76
From £76

2,2-Bis[4-(4-aminophenoxy)phenyl]propane (BAPP)

£56
From £56

1,4-Bis(4-aminophenoxy)benzene (TPE-Q)

£76
From £76

4,4'-Oxydiphthalic anhydride (ODPA)

£76
From £76

2,2-Bis(3-amino-4-hydroxyphenyl)hexafluoropropane (6FAP)

£76
From £76

9,9-Bis(4-aminophenyl)fluorene (FDA)

From £100

4,4'-(4,4'-isopropylidenediphenoxy)bis-(phthalic anhydride) (BPADA)

£76
From £76

2,2'-Bis(trifluoromethyl)benzidine (TFMB)

£76
From £76

4,4'-(1,3-Phenylenedioxy)dianiline (TPE-R)

£70
From £70

2,2'-Dimethyl[1,1'-biphenyl]-4,4'-diamine

£76
From £76

3,4'-Oxydianiline (3,4'-ODA)

£90
From £90

1,2,4,5-cyclohexanetetracarboxylic dianhydride (HPMDA)

£76
From £76

4,4'-Bis(4-aminophenoxy)biphenyl (BAPB)

£76
From £76

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA)

£90
From £90

1,4-Bis(4-amino-2-trifluoromethylphenoxy)benzene (6FAPB)

£76
From £76

2,2-Bis[4-(4-aminophenoxy)phenyl]hexafluoropropane (4-BDAF)

£76
From £76

2,2'-Bis(trifluoromethyl)-4,4'-diaminodiphenyl ether (6FODA)

£76
From £76

1,2,3,4-Butanetetracarboxylic dianhydride (BDA)

£110
From £110

Bicyclo(2.2.2)oct-7-ene-2,3,5,6-tetracarboxylic acid dianhydride (COeDA)

£110
From £110

4,4'-Bis(3-aminophenoxy)biphenyl (43BAPOBP)

£90
From £90

2,3,3',4'-Biphenyltetracarboxylic dianhydride (a-BPDA)

From £80

Dicyclohexyl-3,4,3',4'-tetracarboxylic dianhydride (HBPDA)

From £100

4-Phenylethynylphthalic anhydride (PEPA)

From £110

4-Bromo-N-(4-bromophenyl)-N-(4-(sec-butyl)phenyl)aniline

From £220

2,2-Bis(3-(3-aminobenzoylamino)-4-hydroxyphenyl)hexafluoropropane (m-6FDAP)

£130
From £130

p-6FDAP

£110
From £110

AB-TFMB

£90
From £90

2-Fluoro-9H-carbazole

From £135

7-Hydroxy-4-(trifluoromethyl)coumarin

From £56

7-(Diethylamino)-4-(trifluoromethyl)coumarin

From £110

2-Furoyltrifluoroacetone

From £100

2-(Trifluoromethyl)thioxanthen-9-one

Price £95

5-(Trifluoromethyl)-2-pyridone

From £100

3-(Trifluoromethyl)-2-pyridone

From £100

1-[2-(Trifluoromethyl)phenyl]imidazole

From £175

4-(Trifluoromethyl)-1H-imidazole

From £165

4-Fluoroindole

From £100

3-(4-Fluorophenyl)-1-isopropylindole

From £100

7-Fluoroindole

From £170

5-Fluoroindole

From £100

6-Fluoroindole

From £80

6-Fluoroindole-2-carboxylic acid

From £105

5-(Trifluoromethoxy)isatin

From £115

5-Fluorooxindole

From £200

5-Fluoroisatin

From £76

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate

From £100

3-Fluoro-4-morpholinoaniline

From £100

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

From £115

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

From £80

1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone

From £90

5-Bromo-2-fluoropyridine

From £105

4,4′-Bis(trifluoromethyl)-2,2′-bipyridine

From £100

2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone

From £100

2,4-Difluorobenzonitrile

From £66

2-Amino-4-fluorophenol

From £56

4-Fluoro-3-nitrobenzoic acid

From £66

3,3-Difluoropyrrolidine hydrochloride

From £110

2-Fluoroadenine

From £90

4-Bromo-2,6-difluoroaniline

From £76

(R)-(−)-3-Fluoropyrrolidine hydrochloride

From £72

5-Fluorosalicylic acid

From £110

Methyl pentafluorobenzoate

From £76

(S)-(+)-3-Fluoropyrrolidine hydrochloride

From £80

N-Boc-trans-4-fluoro-L-proline

From £76

Bis(4-fluorophenyl)methanol

From £105

2-Fluoro-5-nitrobenzonitrile

From £72

2-Bromo-6-fluorobenzaldehyde

From £100

2-Chloro-5-fluoropyrimidine

From £100

3-Fluoro-2-hydroxybenzaldehyde

From £110

2-Bromo-4-fluoropyridine

From £125

6-Fluoronicotinic acid

From £76

3,5-Difluorobenzonitrile

From £65

1-Bis(4-fluorophenyl)methyl piperazine

From £80

2-Fluoro-5-nitrobenzoic acid

From £65

4-Fluorobenzenesulfonamide

From £65

3,4,5-Trifluoroaniline

From £55

4-Fluororesorcinol

From £70

2-Bromo-3′-fluoroacetophenone

From £116

3,4,5-Trifluorobenzoic acid

From £90

N-Boc-4,4-difluoro-L-proline

From £70

2-Fluoro-4-(trifluoromethyl)aniline

From £90

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

From £90

4-Fluoro-β-nitrostyrene

From £90

2,2-Difluorocyclopropanecarboxylic acid

From £90

3,3-Difluoropiperidine hydrochloride

From £60

α,α-Difluorophenylacetic acid

From £70

3-Fluoro-4-hydroxybenzaldehyde

From £80

2-Amino-3-fluoropyridine

From £80

3-Fluoro-2-pyridinecarbonitrile

From £70

2-Bromo-4-fluorobenzonitrile

From £80

3′-Fluoro-4′-methoxyacetophenone

Price £90

3-Fluoro-p-anisidine

From £90

2-Amino-6-fluorobenzonitrile

From £90

3-Fluoro-2-methylbenzoic acid

From £90

2-Fluoro-4-nitroaniline

From £70

4-Chloro-3-fluoroaniline

From £50

2,4,5-Trifluorobenzonitrile

From £80

4-Fluoro-2-methylphenol

From £60

2-Amino-5-fluorobenzonitrile

From £80

3-Fluorobenzoic hydrazide

From £100

2-Fluoro-3-methoxybenzaldehyde

From £137