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Product Code B2621-10g
Price $100 ex. VAT

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A dihalogenated benzonitrile building block

Used as a molecular scaffold and building building block for APIs

2-Bromo-4-fluorobenzonitrile (CAS number 36282-26-5) has a bromide and a fluoride substituents on benzonitrile at ortho- and para-position, respectively. With three different functional groups, 2-bromo-4-fluorobenzonitrile is commonly used as a molecular scaffold for active pharmaceutical ingredients (APIs). The bromo-substituent can undergo Pd catalysed C-C coupling, while the fluoride is an ideal leaving group for nucleophilic aromatic substitution. The nitrile group not only acts as the activator for the nucleophilic substitution, but also can react with hydroxylamine to form oxadiazoles. The oxadiazole derivatives are type 2 cannabinoid receptors used for treatments of central nervous system disorders.

2-Bromo-4-fluorobenzonitrile is also used to introduce reactive functional groups to molecular scaffolds and as a substrate with multiple functional groups in synthetic chemistry.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzonitrile building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 36282-26-5

High purity

>98% High purity

General Information

CAS Number 36282-26-5
Chemical Formula C7H3BrFN
Full Name 2-Bromo-4-fluorobenzonitrile
Molecular Weight 200.01 g/mol
Synonyms 4-Fluoro-2-bromobenzonitrile
Classification / Family Fluorinated building blocks, Benzonitrile building blocks, Heterocycles, APIs

Chemical Structure

2-Bromo-4-fluorobenzonitrile chemical structure, CAS 36282-26-5.
2-Bromo-4-fluorobenzonitrile chemical structure, CAS 36282-26-5

Product Details

Purity 97%
Melting Point Tm = 77 °C
Appearance Pale purple powder

MSDS Documentation

2-Bromo-4-fluorobenzonitrile2-Bromo-4-fluorobenzonitrile MSDS Sheet

Literature and Reviews

  1. Cannabinoid receptor type 2 (CB2)-selective N-aryl-oxadiazolyl-propionamides: synthesis, radiolabelling, molecular modelling and biological evaluation, T. Rühl et al., Org. Med. Chem. Lett., 2(1), 32(2012); DOI: 10.1186/2191-2858-2-32.
  2. Highly triplet energy iridium(III) isocyanoborato complex for photochemical up conversion, photoredox and energy transfer catalysis, L. Schmid et al., J. Am. Chem. Soc., 144, 963–976(2022); DOI: 10.1021/jacs.1c11667.
  3. Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity, L. Woo et al., ACS Med. Chem. Lett., 2, 243–247(2011); DOI: 10.1021/ml100273k.
  4. Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based α-helix mimetic, C. Cummings et al., Org. Lett., 11(1), 25–28(2009); DOI: 10.1021/ol8022962.
  5. Design, synthesis and evaluation of small molecule Hsp90 probes, T. Taldone et al., Bioorg. Med. Chem., 19(8), 2603–2614(2011); DOI: 10.1016/j.bmc.2011.03.013.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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