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Product Code B1601-1g
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A fluorinated coumarin derived building block

Used as a synthesis intermediate for dyes in applications of DSSCs, OLEDs and sensors


7-Hydroxy-4-(trifluoromethyl)coumarin (CAS number 575-03-1), derived from coumarin, is a pyrone fused benzene heterocyclic compound with a hydroxy group at 7-position and a trifluoromethyl substituent at 4-position. By having the electron delocalised core, 7-Hydroxy-4-(trifluoromethyl)coumarin is widely used as dyes and emitters in dye-sensitized solar cells (DSSCs) and OLEDs. 7-Hydroxy-4-(trifluoromethyl)coumarin has a strong binding affinity with H2S/HS. The fluorescence intensity of 7-hydroxy-4-(trifluoromethyl)coumarin increases after the binding activity, which makes it a chemical sensor for detecting H2S/HS. The photosensitivity of 7-hydroxy-4-(trifluoromethyl)coumarin is not limited to a specific chemical, but also related to the medium microviscosity and polarity. It allows 7-hydroxy-4-(trifluoromethyl)coumarin to be uses in monitoring chemical reactions such as polymerization.

7-Hydroxy-4-(trifluoromethyl)coumarin has also shown the theoretical possibility of proton transfer/proton shuttling under excitation, based on the change of photoacidity.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated coumarin building block

For drug discovery, solar cells, and OLEDs

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High purity 575-03-01

High purity

>98% High purity

General Information

CAS Number 575-03-1
Chemical Formula C10H5F3O3
Full Name 7-Hydroxy-4-trifluoromethylcoumarin
Molecular Weight 230.14 g/mol
Synonyms 4-(Trifluoromethyl)umbelliferone, 7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one
Classification / Family Fluorinated building block, Heterocyclic building block, Dyes, DSSCs, OLED, Sensors

Chemical Structure

7-Hydroxy-4-(trifluoromethyl)coumarin chemical structure, CAS 575-03-1
7-Hydroxy-4-(trifluoromethyl)coumarin chemical structure, CAS 575-03-1

Product Details

Purity 98%
Melting Point Tm = 178 °C – 180 °C
Appearance Pale purple powder

MSDS Documentation

7-Hydroxy-4-(trifluoromethyl)coumarin7-Hydroxy-4-(trifluoromethyl)coumarin MSDS Sheet

Literature and Reviews

  1. A tyrosinase fluorescent probe with large Stokes shift and high fluorescence enhancement for effective identification of liver cancer cells, Q. Sun et al., Spectrochim. Acta A Mol. Biomol. Spectrosc., 285, 12183(2023); DOI: 10.1016/j.saa.2022.121831.
  2. 4-Trifluoromethyl-substituted coumarins with large stokes shifts: synthesis, bioconjugates, and their use in super-resolution fluorescence microscopy, H. Schill et al., Chem. Eur. J., 19, 16556-16565(2013); DOI: 10.1002/chem.201302037.
  3. Concerted electron-proton transfer in the optical excitation of hydrogen-bonded dyes, B. Westlake et al., PNAS, 108, 21(2011); DOI: 10.1073/pnas.1104811108.
  4. Mechanism of interaction of coumarin-based fluorescent molecular probes with polymerizing medium during free radical polymerization of a monomer, I. Kamińska et al., Polym. Test., 55, 310-317(2016); DOI: 10.1016/j.polymertesting.2016.09.013.
  5. Intermolecular proton shuttling in excited state proton transfer reaction: insights from theory, M. Savarese et al., Phys. Chem. Chem. Phys., 16, 8661-8666(2014); DOI: 10.1039/C4CP00068D.
  6. The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives, Y. Chen et al., Sci. Rep., 8, 16159(2018); DOI: 10.1038/s41598-018-34331-9.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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