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Product Code B3441-2g
Price £40 ex. VAT

A fluorinated phenylacetic acid

Used as an additive for perovskite solar cells, as well as a synthesis intermediate for active pharmaceutical ingredients (APIs)


Specifications | MSDS | Literature and Reviews


2,4,5-Trifluorophenylacetic acid (CAS number 209995-38-0) is a phenylacetic acid with three fluorine atoms substituted on the benzene ring. 2,4,5-Trifluorophenylacetic acid is applied as a bifunctional additive for stable and efficient perovskite solar cell. The carboxylic acid group within 2,4,5-trifluorophenylacetic acid interacts with the Pb cluster and passivates the deep-energy-level defects of the perovskites. This leads to an enhancement of power conversion efficiency (PCE) from 22.95% to 24.56% (device structure: FTO/TiO2/2,4,5-Trifluorophenylacetic acid:FAI:PbI/Spiro-OMeTAD:LiTFSI:tBP/Au). Additionally, the hydrophobicity of the trifluorobenzene moiety improves the stability of the solar cell, maintaining 93.6% of its initial efficiency when stored in air for 3912 hours.

2,4,5-Trifluorophenylacetic acid is also a precursor for the synthesis of sitagliptin through a four-step reaction with an overall yield of 65%. Sitagliptin is an anti-diabetic medication for the treatment of type-2 diabetes.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated phenylacetic acid building block

Fluorinated phenylacetic acid building block

For drug discovery, medicinal chemistry, and perovskite solar cells

competitively priced 209995-38-0

Low Cost

Competitively priced, high quality product

High purity 209995-38-0

High purity

>98% High purity

General Information


CAS Number 209995-38-0
Chemical Formula C8H5F3O2
Full Name (2,4,5-Trifluorophenyl)acetic acid
Molecular Weight 190.12 g/mol
Synonyms 2,4,5-Trifluorobenzeneacetic acid, 2-(2,4,5-Trifluorophenyl)acetic acid, TFPB
Classification / Family Fluorinated building blocks, Phenylacetic acid building blocks, Perovskite solar cell additives, Solid additive, APIs

Chemical Structure


2,4,5-Trifluorophenylacetic acid chemical structure, CAS 209995-38-0
2,4,5-Trifluorophenylacetic acid chemical structure, CAS 209995-38-0

Product Details


Purity 98%
Melting Point Tm = 121 °C – 125 °C
Appearance White powder

MSDS Documentation


2,4,5-Trifluorophenylacetic acid2,4,5-Trifluorophenylacetic acid MSDS Sheet

Literature and Reviews


  1. Bifunctional trifluorophenylacetic acid additive for stable and highly efficient flexible perovskite solar cell, Y. Cao et al., InfoMat., 5, e12423 (2023); DOI: 10.1002/inf2.12423.
  2. Mechanistic evidence for an α-oxoketene pathway in the formation of β-ketoamides/esters via Meldrum's acid adducts, F. Xu et al., J. Am. Chem. Soc., 126, 13002–13009 (2004); DOI: 10.1021/ja046488b.
  3. Highly efficient asymmetric synthesis of sitagliptin, K. Hansen et al., J. Am. Chem. Soc., 131, 8789–8804 (2009); DOI: 10.1021/ja902462q.
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