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3-Fluoro-2-hydroxybenzaldehyde

CAS Number 394-50-3

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B2401-5g
Price $138 ex. VAT

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A fluorinated hydroxybenzaldehyde building block

For synthesizing salen/salalen ligands, bicyclic heterocycles and macromolecules in application of APIs, semiconductors and gas storage


3-Fluoro-2-hydroxybenzaldehyde (CAS number 394-50-3), also known as 3-Fluorosalicylaldehyde, is a benzaldehyde derivative with a fluorine at 3-position and a hydroxy at 2-position. 3-Fluoro-2-hydroxybenzaldehyde is commonly used to synthesize salen (salicylaldehyde and ethylenediamine) ligands as tetradentate C2-symmertic ligands. Cobalt-salen complexes based on 3-fluoro-2-hydroxybenzaldehyde show reversible oxygen chemisorption as well as anticancer activity with IC50 (half maximal inhibitory concentration) of 50 µM.

By having three chemically reactive sites, 3-fluoro-2-hydroxybenzaldehyde is used to synthesize fluorinated bicyclic heterocycles such as isoflavanone (chromanone) through gold(I) catalysed annulation reaction. Semiconducting acenes can also be prepared from 3-fluoro-2-hydroxybenzaldehyde.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated salicylaldehyde building block

For drug discovery, organometallic ligands and semiconducting materials

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High purity 394-50-3

High purity

>97% High purity

General Information

CAS Number 394-50-3
Chemical Formula C7H5FO2
Full Name 3-Fluoro-2-hydroxybenzaldehyde
Molecular Weight 140.11 g/mol
Synonyms 3-Fluorosalicylaldehyde, 2-Hydroxy-3-fluorobenzaldehyde
Classification / Family Fluorinated building block, Salicylaldehyde building block, Schiff bases, APIs, Semiconductors, Gas storage

Chemical Structure

3-Fluoro-2-hydroxybenzaldehyde chemical structure, CAS 394-50-3
3-Fluoro-2-hydroxybenzaldehyde chemical structure, CAS 394-50-3

Product Details

Purity 97%
Melting Point Tm = 68  70 °C 
Appearance White to off-white powder

MSDS Documentation

3-Fluoro-2-hydroxybenzaldehyde3-Fluoro-2-hydroxybenzaldehyde MSDS Sheet

Literature and Reviews

  1. Regioselective fluorination of acenes: tailoring of molecular electronic levels and solid-state properties, D. Bischof et al., Chem. Eur. J., 28, e202103653(2022); DOI: 10.1002/chem.202103653.
  2. Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors, E. Amato et al., Bioorg. Med. Chem., 22(1), 126–134(2014); DOI: 10.1016/j.bmc.2013.11.045.
  3. Physical properties, ligand substitution reactions, and biological activity of Co(III)-Schiff base complexes, A. King et al., Dalton Trans., 48, 5987–6002(2019); DOI: 10.1039/C8DT04606A.
  4. Structure activity relationships for reversible O2 chemisorption by the solid phases of Co(salen) and Co(3F-salen), M. Møller et al., JACS Au, 3, 1484−1495(2023); DOI: 10.1021/jacsau.3c00134.
  5. The influences of electronic effect and isomerization of salalen titanium(IV) complexes on ethylene polymerization in the presence of methylaluminoxane, RSC Adv., 9, 41824(2019); DOI: 10.1039/c9ra08899g.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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