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5-Difluoromethoxy-2-mercaptobenzimidazole

CAS Number 97963-62-7

Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers


Product Code B2991-25g
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A fluorinated mercaptobenzimidazole building block

Used as a synthesis intermediate for APIs in medicinal chemistry


5-Difluoromethoxy-2-mercaptobenzimidazole (CAS number 97963-62-7) is the mercaptan derivative of benzimidazole, bearing a difluoromethoxy group substituted on the 5-position. 5-Difluoromethoxy-2-mercaptobenzimidazole is one of the key intermediates of pantoprazole, a proton pump inhibitor used for the treatment of stomach ulcers. Pantoprazole works by reducing the production of gastric acid and inactivating H+-ATPase in the stomach. The synthesis of pantoprazole starts with the coupling reaction of 5-difluoromethoxy-2-mercaptobenzimidazole with 2-chloromethyl-3,4-dimethoxypyridinium hydrochloride, followed by an oxidation reaction.

5-Difluoromethoxy-2-mercaptobenzimidazole is also utilised in the preparation of α‑glucosidase inhibitors for their efficacy in antidiabetic activity.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity

High purity

>97% High purity

General Information

CAS Number 97963-62-7
Chemical Formula C8H6F2N2OS
Full Name 5-(Difluoromethoxy)-1,3-dihydro-2H-benzimidazole-2-thione
Molecular Weight 216.21 g/mol
Synonyms 5-(Difluoromethoxy)-2-benzimidazolethiol, Pantoprazole related compound C
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Benzimidazole building blocks, APIs

Chemical Structure

5-Difluoromethoxy-2-mercaptobenzimidazole chemical structure, CAS 97963-62-7.
5-Difluoromethoxy-2-mercaptobenzimidazole chemical structure, CAS 97963-62-7

Product Details

Purity 97%
Melting Point Tm = 239 °C – 243 °C
Appearance White powder

MSDS Documentation

5-Difluoromethoxy-2-mercaptobenzimidazole5-Difluoromethoxy-2-mercaptobenzimidazole MSDS Sheet

Literature and Reviews

  1. Design, synthesis and biological evaluation of novel 3-hydroxypyridin-4(1H)-ones based hybrids as Pseudomonas aeruginosa biofilm inhibitors, J. Liu et al., Eur. J. Med. Chem., 259, 115665(2023); DOI: 10.1016/j.ejmech.2023.115665.
  2. Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate, A. Awasthi et al., J. Pharm. Anal., 9, 170–177(2019); DOI: 10.1016/j.jpha.2019.02.002.
  3. Mecaptobenzimidazole-based 1,3-thaizolidin-4-ones as antidiabetic agents: synthesis, in vitro α‑glucosidase inhibition activity, and molecular docking studies, S. Khan et al., ACS Omega, 7, 28041–28051(2022); DOI: 10.1021/acsomega.2c01969.
  4. On the mechanism of formation and the synthesis of pantoprazole sodium sesquihydrate-related compound E: a phantom chemical entity, A. Yari et al., ACS Omega, 4, 737–744(2019); DOI: 10.1021/acsomega.8b00845.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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