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6-Fluoropyridine-2-carbonitrile

CAS Number 3939-15-9

Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers


Product Code B2901-1g
Price £80 ex. VAT

A fluorinated pyridine building block

For the synthesis of metal-organic complexes and APIs


Specifications | MSDS | Literature and Reviews


6-Fluoropyridine-2-carbonitrile (CAS number 3939-15-9) is a pyridine derivative substituted with a nitrile and a fluorine at the two ortho-positions. 6-Fluoropyridine-2-carbonitrile can form a centrosymmetric dinuclear complex with silver (AgI). The complex exhibits a molecular ladder-like structure linked by the BF4- counteranion via Ag-F interactions. 6-Fluoropyridine-2-carbonitrile can be attached to molecular scaffolds effectively through nucleophilic aromatic substitution.

The nitrile group in 6-fluoropyridine-2-carbonitrile reacts with thiols or amines to produce thiazoles and imidazoles. These heterocyclic compounds are widely used as active pharmaceutical ingredients (APIs).

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated pyridine building block

for drug discovery, medicinal chemistry and biochemistry research

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High purity 3939-15-9

High purity

>97% High purity

General Information


CAS Number 3939-15-9
Chemical Formula C6H3FN2
Full Name 6-Fluoropyridine-2-carbonitrile
Molecular Weight 122.10 g/mol
Synonyms 2-Cyano-6-fluoropyridine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Ligands, APIs

Chemical Structure


6-Fluoropyridine-2-carbonitrile chemical structure, CAS 3939-15-9.
6-Fluoropyridine-2-carbonitrile chemical structure, CAS 3939-15-9

Product Details


Purity 97%
Melting Point Tm = 31 °C – 35 °C
Appearance Pale blue crystals

MSDS Documentation


6-Fluoropyridine-2-carbonitrile6-Fluoropyridine-2-carbonitrile MSDS Sheet

Literature and Reviews


  1. Bis(l-2-cyanopyridine-N:N')bis-[(2-cyanopyridine-N)silver(I)]bis(tetrafluoroborate): an anion-linked molecular ladder, A. Blake et al., Acta Cryst., C57, 1290–1291(2001); ISSN 0108-2701.
  2. Characterization of N-glucuronidation of 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile (FYX-051): a new xanthine oxidoreductase inhibitor, K. Omura et al., Drug Metab. Dispos., 35(12), 2143–2148(2007); DOI: 10.1124/dmd.107.017251.
  3. Biocompatible macrocyclization between cysteine and 2-cyanopyridine generates stable peptide inhibitors, C. Nitsche et al., Org. Lett., 21(12), 4709–4712(2019); DOI: 10.1021/acs.orglett.9b01545.

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