6-Fluoropyridine-2-carbonitrile

CAS Number 3939-15-9

Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

6-Fluoropyridine-2-carbonitrile CAS 3939-15-9

A fluorinated pyridine building block

For the synthesis of metal-organic complexes and APIs

Overview
Related Products

6-Fluoropyridine-2-carbonitrile (CAS number 3939-15-9) is a pyridine derivative substituted with a nitrile and a fluorine at the two ortho-positions. 6-Fluoropyridine-2-carbonitrile can form a centrosymmetric dinuclear complex with silver (Ag^I). The complex exhibits a molecular ladder-like structure linked by the BF₄^- counteranion via Ag-F interactions. 6-Fluoropyridine-2-carbonitrile can be attached to molecular scaffolds effectively through nucleophilic aromatic substitution.

The nitrile group in 6-fluoropyridine-2-carbonitrile reacts with thiols or amines to produce thiazoles and imidazoles. These heterocyclic compounds are widely used as active pharmaceutical ingredients (APIs).

Multiple functional groups

For facile synthesis

Fluorinated pyridine building block

for drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	3939-15-9
Chemical Formula	C₆H₃FN₂
Full Name	6-Fluoropyridine-2-carbonitrile
Molecular Weight	122.10 g/mol
Synonyms	2-Cyano-6-fluoropyridine
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, Ligands, APIs

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 31 °C – 35 °C
Appearance	Pale blue crystals

MSDS Documentation

6-Fluoropyridine-2-carbonitrile MSDS Sheet

Literature and Reviews

Bis(l-2-cyanopyridine-N:N')bis-[(2-cyanopyridine-N)silver(I)]bis(tetrafluoroborate): an anion-linked molecular ladder, A. Blake et al., Acta Cryst., C57, 1290–1291(2001); ISSN 0108-2701.
Characterization of N-glucuronidation of 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile (FYX-051): a new xanthine oxidoreductase inhibitor, K. Omura et al., Drug Metab. Dispos., 35(12), 2143–2148(2007); DOI: 10.1124/dmd.107.017251.
Biocompatible macrocyclization between cysteine and 2-cyanopyridine generates stable peptide inhibitors, C. Nitsche et al., Org. Lett., 21(12), 4709–4712(2019); DOI: 10.1021/acs.orglett.9b01545.
Novel synthesis of 2,4-bis(2-pyridyl)-5-(pyridyl)imidazoles and formation of N-(3-(pyridyl)imidazo[1,5-a]pyridine)picolinamidines: nitrogen-rich ligands, V. Fulwa et al., Tetrahedron Lett., 50, 6264–6267(2009); DOI: 10.1016/j.tetlet.2009.09.002.

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