4-Methoxy-3-(trifluoromethyl)aniline

CAS Number 393-15-7

4-Methoxy-3-(trifluoromethyl)aniline CAS 393-15-7

A fluorinated anisidine building block

A synthetic substrate in organic synthesis and a precursor for bicyclic heterocycles

Overview
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4-Methoxy-3-(trifluoromethyl)aniline (CAS number 393-15-7) is a derivative of anisidine, with a trifluoromethyl substituent introduced at 3-position. 4-Methoxy-3-(trifluoromethyl)aniline is also referred to as anisole, due to the presence of a methoxybenzene moiety. 4-Methoxy-3-(trifluoromethyl)aniline is commonly utilised as a substrate in organic synthesis for studying amine/aniline-related reactions.

4-Methoxy-3-(trifluoromethyl)aniline is also used for synthesising substituted bicyclic heterocycles, including quinolines, benzotriazoles and benzimidazoles analogues. These applications are particularly relevant to the development of active pharmaceutical ingredients (APIs), showing strong antitumor and antiviral activities.

Multiple functional groups

For facile synthesis

Fluorinated aniline building block

for drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	393-15-7
Chemical Formula	C₈H₈F₃NO
Full Name	4-Methoxy-3-(trifluoromethyl)aniline
Molecular Weight	191.15 g/mol
Synonyms	3-(Trifluoromethyl)-p-anisidine, 4-Amino-2-(trifluoromethyl)anisole, 4-Methoxy-3-(trifluoromethyl)benzenamine, 5-Amino-2-methoxybenzotrifluoride
Classification / Family	Fluorinated building blocks, Aniline building blocks, Anisidine building blocks, Anisole building blocks, Organic synthesis, Heterocycles

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 58 °C – 60 °C
Appearance	Pale pink powder/crystals

MSDS Documentation

4-Methoxy-3-(trifluoromethyl)aniline MSDS Sheet

Literature and Reviews

A general method for N-methylation of amines and nitro compounds with dimethylsulfoxide, X. Jiang et al., Chem. Eur. J., 20, 58–63(2014); DOI: 10.1002/chem.201303802.
Trisubstituted imidazole synthesis: a review, N. Rani et al., Mini-Rev. Org. Chem., 12(1), 34–65(2015); DOI: 10.2174/1570193X11666141028235010.
Synthesis and leishmanicidal activity of molecular hybrids 1,2,3-trazole-chalcones, S. Rodríguez-Gutiérrez et al., Chem. Proc., 3, 55(2021); DOI: 10.3390/ecsoc-24-08356.
Enantioselective synthesis of α-trifluoromethyl amines via biocatalytic N−H bond insertion with acceptor-acceptor carbene donors, J. Am. Chem. Soc., 144, 2590–2602(2022); DOI: 10.1021/jacs.1c10750.

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