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CAS Number 393-15-7

Fluorinated Building Blocks, Materials, Monomers

Product Code B2811-1g
Price £90 ex. VAT

A fluorinated anisidine building block

A synthetic substrate in organic synthesis and a precursor for bicyclic heterocycles

Specifications | MSDS | Literature and Reviews

4-Methoxy-3-(trifluoromethyl)aniline (CAS number 393-15-7) is a derivative of anisidine, with a trifluoromethyl substituent introduced at 3-position. 4-Methoxy-3-(trifluoromethyl)aniline is also referred to as anisole, due to the presence of a methoxybenzene moiety. 4-Methoxy-3-(trifluoromethyl)aniline is commonly utilised as a substrate in organic synthesis for studying amine/aniline-related reactions.

4-Methoxy-3-(trifluoromethyl)aniline is also used for synthesising substituted bicyclic heterocycles, including quinolines, benzotriazoles and benzimidazoles analogues. These applications are particularly relevant to the development of active pharmaceutical ingredients (APIs), showing strong antitumor and antiviral activities.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated aniline building block

for drug discovery, medicinal chemistry and biochemistry research

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High purity 393-15-7

High purity

>97% High purity

General Information

CAS Number 393-15-7
Chemical Formula C8H8F3NO
Full Name 4-Methoxy-3-(trifluoromethyl)aniline
Molecular Weight 191.15 g/mol
Synonyms 3-(Trifluoromethyl)-p-anisidine, 4-Amino-2-(trifluoromethyl)anisole, 4-Methoxy-3-(trifluoromethyl)benzenamine, 5-Amino-2-methoxybenzotrifluoride
Classification / Family Fluorinated building blocks, Aniline building blocks, Anisidine building blocks, Anisole building blocks, Organic synthesis, Heterocycles

Chemical Structure

4-Methoxy-3-(trifluoromethyl)aniline chemical structure, CAS 393-15-7.
4-Methoxy-3-(trifluoromethyl)aniline chemical structure, CAS 393-15-7

Product Details

Purity 97%
Melting Point Tm = 58 °C – 60 °C
Appearance Pale pink powder/crystals

MSDS Documentation

4-Methoxy-3-(trifluoromethyl)aniline4-Methoxy-3-(trifluoromethyl)aniline MSDS Sheet

Literature and Reviews

  1. A general method for N-methylation of amines and nitro compounds with dimethylsulfoxide, X. Jiang et al., Chem. Eur. J., 20, 58–63(2014); DOI: 10.1002/chem.201303802.
  2. Trisubstituted imidazole synthesis: a review, N. Rani et al., Mini-Rev. Org. Chem., 12(1), 34–65(2015); DOI: 10.2174/1570193X11666141028235010.
  3. Synthesis and leishmanicidal activity of molecular hybrids 1,2,3-trazole-chalcones, S. Rodríguez-Gutiérrez et al., Chem. Proc., 3, 55(2021); DOI: 10.3390/ecsoc-24-08356.
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