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Product Code B1621-25g
Price $125 ex. VAT

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A fluorinated β-diketone building block

Used as a synthesis intermediate for metal complexes, isoxazoles, pyrimidine and pyrazoles in application of OLEDs, displays, and drug discovery

2-Furoyltrifluoroacetone (CAS number 326-90-9) is a derivative of β-diketone with a furan and a trifluoromethyl substituents. 2-Furoyltrifluoroacetone is directly applied as a ligand to the synthesis of luminescent terbium (Tb III) and lanthanide (Ln III) complexes that are used OLEDs and displays. The complexes have high quantum efficiency of 77% and long lifetime of 842 μs.

The furan of 2-Furoyltrifluoroacetone can be easily modified via Diels-Alder reactions (with electron deficient dienophiles) and electrophilic substitution.

The β-diketone (1,3-diketone) moiety is a precursor for many other heterocyclic compounds. 2-Furoyltrifluoroacetone reacts with hydrazine to form pyrazole, with hydroxylamine to form isoxazole, and with urea pyrimidine. The heterocyclic compounds are investigated as active pharmaceutical ingredients (APIs) for anticancer and anti-inflammatory drug discovery.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated diketone building block

For drug discovery, ligands, and OLEDs

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High purity 326-90-9

High purity

>98% High purity

General Information

CAS Number 326-90-9
Chemical Formula C8H5F3O3
Full Name 4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione
Molecular Weight 206.12 g/mol
Synonyms Perfluoroacetyl(2-furoyl)methane
Classification / Family Fluorinated building block, Heterocyclic building block, Diketone Derivatives, Pyrazoles, OLEDs, APIs, Display

Chemical Structure

2-Furoyltrifluoroacetone chemical structure, CAS 326-90-9
2-Furoyltrifluoroacetone chemical structure, CAS 326-90-9

Product Details

Purity 98%
Melting Point Tm = 19 °C – 21 °C
Boiling Point Tb= 203 °C at 760 mmHg
Relative Density 1.391 g/mL at 25 °C
Appearance Clear liquid

MSDS Documentation

2-Furoyltrifluoroacetone2-Furoyltrifluoroacetone MSDS Sheet

Literature and Reviews

  1. Luminescent Tb(III) complexes with Lewis bases for displays: Synthesis and spectral investigation, A. Hooda et al, Inorg. Chem. Commun., 151, 110583(2023); DOI: 10.1016/j.inoche.2023.110583.
  2. Anticancer activity of novel 3‐(furan‐2‐yl)pyrazolyl and 3‐(thiophen‐2‐yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies, M. Helmy et al., Arch. Pharm., 355, e2100381(2022); DOI: 10.1002/ardp.202100381.
  3. Exploration of photophysical behavior of lanthanide complex and its hybrids, S. Wankar et al., Spectrochim. Acta A Mol. Biomol., 254, 119629(2021); DOI: 10.1016/j.saa.2021.119629.
  4. Heteroaromatic analogues of 1,5-diarylpyrazole class as anti-inflammatory agents, P. Sharma et al., Med. Chem. Res., 21, 3757–3766(2012); DOI: 10.1007/s00044-011-9898-4.
  5. Improved regioselectivity in pyrazole formation through the use of fluorinated alcohols as solvents: synthesis and biological activity of fluorinated tebufenpyrad analogs, S. Fustero et al., J. Org. Chem., 73, 3523–3529(2008); DOI: 10.1021/jo800251g.
  6. Structure-related mode-of-action differences of anticancer organoruthenium complex with β-diketonates, S. Seršen et al., J. Med. Chem., 58(9), 3984–3996(2015); DOI: 10.1021/acs.jmedchem.5b00288.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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