FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate

CAS Number 168828-81-7

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers

Product Code B1771-25g
Price $125 ex. VAT

A fluorinated heterocyclic building block

Used as a synthesis intermediate for APIs and non-linear optical materials

Specifications | MSDS | Literature and Reviews

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate (CAS number 168828-81-7) is a fluorinated heterocyclic compound, bearing a morpholine (a 6-membred heterocycle), a fluorobenzene, a carbamate linker and a benzyl group. Benzyl (3-Fluoro-4-morpholinophenyl)carbamate is one of the intermediates for synthesising linezolid, an antibiotic for treatment of Gram-positive bacteria that is resistant to other antibiotics. To synthesise linezolid, benzyl (3-Fluoro-4-morpholinophenyl)carbamate reacts with bromomethyloxirane forming an oxazolidone moiety. The bromide is subsequently replaced by acetamide to complete the molecular formation. Other than linezolid, benzyl (3-Fluoro-4-morpholinophenyl)carbamate is also used to synthesise glucose uptake inhibitor for supressing the growth of cancer cells.

linezolid chemical structure
The chemical structure of linezolid

A theoretical study has revealed that benzyl (3-Fluoro-4-morpholinophenyl)carbamate has a large first-order hyperpolarizability for potential use in non-linear optical applications.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated morpholinophenyl building block

For drug discovery, medicinal chemistry, and photonics

Worldwide shipping for 168828-81-7

Worldwide shipping

Quick and reliable shipping

High purity 168828-81-7

High purity

>98% High purity

General Information

CAS Number 168828-81-7
Chemical Formula C18H19FN2O3
Full Name Benzyl (3-Fluoro-4-morpholinophenyl)carbamate
Molecular Weight 303.36 g/mol
Synonyms (3-Fluoro-4-morpholinophenyl)carbamic acid benzyl ester
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, APIs, Photonics

Chemical Structure

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate chemical structure, CAS 168828-81-7
Benzyl (3-Fluoro-4-morpholinophenyl)carbamate chemical structure, CAS 168828-81-7

Product Details

Purity >98%
Melting Point Tm = 125 °C
Appearance Off-white fluffy powder

MSDS Documentation

Benzyl (3-Fluoro-4-morpholinophenyl)carbamateBenzyl (3-Fluoro-4-morpholinophenyl)carbamate MSDS Sheet

Literature and Reviews

  1. A novel and expeditious synthesis of oxazolidinone drugs linezolid and eperezolid, R. Siddaraj et al., Eur. J. Chem., 9(4), 353–359(2018); DOI: 10.5155/eurjchem.9.4.353-359.1783.
  2. Inhibition of glucose transporters and glutaminase synergistically impairs tumor cell growth, E. Reckzeh et al., Cell Chem. Biol., 26, 1214–1228(2019); DOI: 10.1016/j.chembiol.2019.06.005.
  3. The role of oxazolidine derivatives in the treatment of infectious and chronic diseases, J. Branco-Junior et al., Curr. Bioact. Compd., 13(4), 292–304(2017); DOI: 10.2174/1573407213666161214162149.
Return to the top