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Benzyl (3-Fluoro-4-morpholinophenyl)carbamate

CAS Number 168828-81-7

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers


Product Code B1771-25g
Price $125 ex. VAT

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A fluorinated heterocyclic building block

Used as a synthesis intermediate for APIs and non-linear optical materials


Benzyl (3-Fluoro-4-morpholinophenyl)carbamate (CAS number 168828-81-7) is a fluorinated heterocyclic compound, bearing a morpholine (a 6-membred heterocycle), a fluorobenzene, a carbamate linker and a benzyl group. Benzyl (3-Fluoro-4-morpholinophenyl)carbamate is one of the intermediates for synthesising linezolid, an antibiotic for treatment of Gram-positive bacteria that is resistant to other antibiotics. To synthesise linezolid, benzyl (3-Fluoro-4-morpholinophenyl)carbamate reacts with bromomethyloxirane forming an oxazolidone moiety. The bromide is subsequently replaced by acetamide to complete the molecular formation. Other than linezolid, benzyl (3-Fluoro-4-morpholinophenyl)carbamate is also used to synthesise glucose uptake inhibitor for supressing the growth of cancer cells.

linezolid chemical structure
The chemical structure of linezolid

A theoretical study has revealed that benzyl (3-Fluoro-4-morpholinophenyl)carbamate has a large first-order hyperpolarizability for potential use in non-linear optical applications.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated morpholinophenyl building block

For drug discovery, medicinal chemistry, and photonics

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High purity 168828-81-7

High purity

>98% High purity

General Information

CAS Number 168828-81-7
Chemical Formula C18H19FN2O3
Full Name Benzyl (3-Fluoro-4-morpholinophenyl)carbamate
Molecular Weight 303.36 g/mol
Synonyms (3-Fluoro-4-morpholinophenyl)carbamic acid benzyl ester
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, APIs, Photonics

Chemical Structure

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate chemical structure, CAS 168828-81-7
Benzyl (3-Fluoro-4-morpholinophenyl)carbamate chemical structure, CAS 168828-81-7

Product Details

Purity >98%
Melting Point Tm = 125 °C
Appearance Off-white fluffy powder

MSDS Documentation

Benzyl (3-Fluoro-4-morpholinophenyl)carbamateBenzyl (3-Fluoro-4-morpholinophenyl)carbamate MSDS Sheet

Literature and Reviews

  1. A novel and expeditious synthesis of oxazolidinone drugs linezolid and eperezolid, R. Siddaraj et al., Eur. J. Chem., 9(4), 353–359(2018); DOI: 10.5155/eurjchem.9.4.353-359.1783.
  2. Inhibition of glucose transporters and glutaminase synergistically impairs tumor cell growth, E. Reckzeh et al., Cell Chem. Biol., 26, 1214–1228(2019); DOI: 10.1016/j.chembiol.2019.06.005.
  3. The role of oxazolidine derivatives in the treatment of infectious and chronic diseases, J. Branco-Junior et al., Curr. Bioact. Compd., 13(4), 292–304(2017); DOI: 10.2174/1573407213666161214162149.
  4. Synthesis and antibiotic activity of oxazolidinone-catechol conjugates against Pseudomonas aeruginosa, A. Paulen et al., Org. Biomol. Chem., 13, 11401(2015); DOI: 10.1039/c5ob01859e.
  5. Structural parameters, NLO properties, thermodynamic functions, NBO analysis and Fukui functions of benzyl(3-fluoro-4-morpholinophenyl)carbamate by density functional theory, B. Yadav et al., J. Pharm. Negat., 14(1), 1285–1293(2023); DOI: 10.47750/pnr.2023.14.S01.175.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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