2-Amino-5-chloro-3-fluoropyridine

CAS Number 246847-98-3

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

2-Amino-5-chloro-3-fluoropyridine CAS 246847-98-3

A fluorinated aminopyridine building block

For the synthesis of APIs and metal complexes

Overview
Related Products

2-Amino-5-chloro-3-fluoropyridine (CAS number 246847-98-3) is a pyridine derivative substituted with an amine, a fluorine and a chlorine at the 2-, 3- and 5-positions respectively. The pyridinium amine of 2-amino-5-chloro-3-fluoropyridine can easily coordinate to copper centres, in neutral or acidic media. The resulting organometallic complexes exhibit antiferromagnetic interactions under temperatures ranging from −0.9 to −31.3 K.

2-Amino-5-chloro-3-fluoropyridine is also used in the synthesis of active pharmaceutical ingredients (APIs). These APIs include inhibitors of cyclin-de-pendent kinase for cancer treatments and disruptors of glucokinase-glucokinase regulatory protein for type II diabetes mellitus.

Multiple functional groups

For facile synthesis

Fluorinated aminopyridine building block

For drug discovery, medicinal chemistry, and organometallic complexes

Low Cost

Competitively priced, high quality product

High purity

>97% High purity

General Information

CAS Number	246847-98-3
Chemical Formula	C₅H₄ClFN₂
Full Name	5-Chloro-3-fluoro-2-pyridinamine
Molecular Weight	146.55 g/mol
Synonyms	5-Chloro-3-fluoropyridin-2-amine, 5-chloro-3-fluoro-2-pyridylamine
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, Amine building blocks, Organometallic complexes, APIs

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 91 °C – 95 °C
Appearance	Beige powder

MSDS Documentation

2-Amino-5-chloro-3-fluoropyridine MSDS Sheet

Literature and Reviews

Copper(II) complexes of 2-amino-5-chloro-3-fluoropyridine: syntheses and magnetic properties of (3,5-FCAP)₂CuX₂ and (3,5-FCAPH)₂CuX₄, B. Solomon et al., J. Coord. Chem., 67, 3953–3971 (2014); DOI: 10.1080/00958972.2014.893431.
Discovery of potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19, A. Mallinger et al., J. Med. Chem., 59, 1078–1101 (2016); DOI: 10.1021/acs.jmedchem.5b01685.
Discovery and structure-guided optimization of diarylmethanesulfonamide disrupters of glucokinase−glucokinase regulatory protein (GK−GKRP) binding: strategic use of a N → S (n_N → σ*_S−X) interaction for conformational constraint, L. Pennington et al., J. Med. Chem., 58, 9663–9679 (2015); DOI: 10.1021/acs.jmedchem.5b01367.

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