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2-Bromo-3′-fluoroacetophenone

CAS Number 53631-18-8

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers


Product Code B2501-5g
Price $145 ex. VAT

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A dihalogenated acetophenone building block

Used as a precursor for heterocycles and ligands for APIs and phosphorescent complexes


2-Bromo-3′-fluoroacetophenone (CAS number 53631-18-8), alternatively known as 3-fluorophenylacyl bromide, has a fluorine substituent on the benzene ring and a bromine on the α-carbon of the ketone. 2-Bromo-3′-fluoroacetophenone is popularly used to synthesised heterocycles such as pyrazines and thiazoles. Thiazoles are obtained from 2-bromo-3′-fluoroacetophenone reacting with thiourea in ethanol (reflux). The thiazolyl derivatives are applied as correctors of the chloride transport defect in cystic fibrosis, glutathione S-transferase Omega 1 inhibitors and Trypanosoma brucei, to name a few.

2-Bromo-3′-fluoroacetophenone reacts with ortho-phenylenediamine derivatives to produce pyrazine derivatives. Complexes of iridium-pyrazine derivatives show phosphorescent emitting yellow to deep red colours (λem = 579 – 655 nm).

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated acetophenone building block

For phosphorescent complexes, medicinal chemistry and biochemistry research

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High purity 53631-18-8

High purity

>97% High purity

General Information

CAS Number 53631-18-8
Chemical Formula C8H6BrFO
Full Name 2-Bromo-1-(3-fluorophenyl)ethan-1-one
Molecular Weight 217.04 g/mol
Synonyms 3-Fluorophenacyl bromide, 2-Bromo-1-(3-fluorophenyl)ethanone
Classification / Family Fluorinated building blocks, Heterocycles, Phosphorescent complexes, APIs

Chemical Structure

2-Bromo-3′-fluoroacetophenone chemical structure, CAS 53631-18-8.
2-Bromo-3′-fluoroacetophenone chemical structure, CAS 53631-18-8

Product Details

Purity 97%
Melting Point Tm = 33 °C – 37 °C
Appearance White crystals

MSDS Documentation

2-Bromo-3′-fluoroacetophenone MSDS Sheet2-Bromo-3′-fluoroacetophenone MSDS Sheet

Literature and Reviews

  1. Polysubstituted ligand framework for color tuning phosphorescent iridium(III) complexes, S. Fitzgerald et al., Inorg. Chem., 60(20), 15467–15484(2021); DOI: 10.1021/acs.inorgchem.1c02121.
  2. Structure-based design of N-(50phenylthiazol-2-yl)acrylamides as novel and potent glutathione S-transferase omega 1 inhibitors, W. Dai et al., J. Med. Chem., 62(6), 3068–3087(2019); DOI: 10.1021/acs.jmedchem.8b01960.
  3. Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis, E. Pesce et al., Eur. J. Med. Chem., 99, 14–35(2015); DOI: 10.1016/j.ejmech.2015.05.030.
  4. Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense, D. Patrick et al., Bioorg. Med. Chem., 24(11), 2451–2465(2016); DOI: 10.1016/j.bmc.2016.04.006.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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