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Product Code B2611-5g
Price £70 ex. VAT

A fluorinated pyridinecarbonitrile building block

Used as a synthesis intermediate for APIs and phosphorescence dyes

Specifications | MSDS | Literature and Reviews

3-Fluoro-2-pyridinecarbonitrile (CAS number 97509-75-6) is a pyridine derivative having a fluorine and a nitrile group at 3- and 2-positions. 3-Fluoro-2-pyridinecarbonitrile can undergo different reactions, such as nucleophilic aromatic substitutions on the fluorine substituted carbon. It allows 3-fluoro-2-pyridinecarbonitrile to attach to chromophores like carbazoles, for synthesising aggregation-induced emission molecules. Such method is also applied to pharmaceutical compounds, by attaching 3-fluoro-2-pyridinecarbonitrile to negative allosteric modulator small molecules leading to an improved binding affinity to glutamate receptors for the treatment of central nervous system diseases.

3-Fluoro-2-pyridinecarbonitrile is also used to prepare tetrazine through bioorthogonal chemistry with hydrazine. The as-synthesised tetrazines facilitate additional reactions, including tetrazine ligation and [4+1] cycloaddition.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated picolinonitrile building block

For AIE materials, medicinal chemistry and biochemistry research

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High purity 97509-75-6

High purity

>97% High purity

General Information

CAS Number 97509-75-6
Chemical Formula C6H3FN2
Full Name 3-Fluoro-2-pyridinecarbonitrile
Molecular Weight 122.10 g/mol
Synonyms 2-Cyano-3-fluoropyridine, 3-fluoropicolinonitrile, 3-Fluoro-pyridine-2-carbonitrile
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, APIs, Aggregation-induced emission materials, Phosphorescence

Chemical Structure

3-Fluoro-2-pyridinecarbonitrile chemical structure, CAS 97509-75-6.
3-Fluoro-2-pyridinecarbonitrile chemical structure, CAS 97509-75-6

Product Details

Purity 97%
Melting Point Tm = 27 °C – 32 °C
Appearance White crystals

MSDS Documentation

3-Fluoro-2-pyridinecarbonitrile3-Fluoro-2-pyridinecarbonitrile MSDS Sheet

Literature and Reviews

  1. Enabling in vivo photocatalytic activation of rapid bioorthogonal chemistry by repurposing silicon-rhodamine fluorophores as cytocompatible far-red photocatalysts, C. Wang et al., J. Am. Chem. Soc., 143(28), 10793–10803(2021); DOI: 10.1021/jacs.1c05547.
  2. Sonogashira cross-coupling reaction of bromocyanofluoropyridine nuclei: access to 5- and 6-alkynylfluoropyridinamidoximes scaffolds, F. Razafindrainibe et al., Eur. J. Org. Chem., 2021, 4393(2021); DOI: 10.1002/ejoc.202100563.
  3. A readily obtained alternative of 1H-benzo[f]indole towards room temperature ultralong organic phosphorescence, X. Fu et al., Chem. Mater., 35(1), 347–357(2023); DOI: 10.1021/acs.chemmater.2c03484.
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