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Product Code B2421-1g
Price $95 ex. VAT

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A fluorinated nicotinic acid building block

Used as a bioactive molecule for medicinal chemistry research


6-Fluoronicotinic acid (CAS number 403-45-2), also recognized as niacin, is a fluorinated nicotinic acid. 6-Fluoronicotinic acid is a derivative of pyridine, with a carboxylic acid at 3-position and a fluorine at 6-position. Nicotinic acid is an important food supplement and used to treat pellagra, a vitamin B3 deficiency disease. 6-Fluoronicotinic acid is applied as a molecular scaffold to synthesize tracers for positron emission tomography, for visualizing and measuring changes in metabolic processes.

Being bioactive, 6-fluoronicotinic acid is commonly used as a building block for active pharmaceutical ingredients (APIs). A derivative of quinoline-8-yl-nicotinamide synthesised from 6-fluoronicotinic acid is investigated for pancreatic cancer treatment.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated carboxylic acid building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 403-45-2

High purity

>98% High purity

General Information

CAS Number 403-45-2
Chemical Formula C6H4FNO2
Full Name 2-Fluoro-5-pyridinecarboxylic acid
Molecular Weight 141.10 g/mol
Synonyms 6-Fluoropyridine-3-carboxylic acid
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, APIs, Ligands

Chemical Structure

6-Fluoronicotinic acid chemical structure, CAS 403-45-2
6-Fluoronicotinic acid chemical structure, CAS 403-45-2

Product Details

Purity 98%
Melting Point Tm =  144 – 148°C 
Appearance White powder

MSDS Documentation

6-Fluoronicotinic acid6-Fluoronicotinic acid MSDS Sheet

Literature and Reviews

  1. Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [18F]ICF01006, a highly promising melanoma PET tracer, L. Rbah-Vidal et al., Eur. J. Nucl. Med. Mol. Imaging, 39, 1449–1461(2012); DOI: 10.1007/s00259-012-2168-y.
  2. Fast indirect fluorine-18 labelling of protein/peptide using the useful 6-fluoronicotinic acid-2,3,5,6-tetrafluorophenyl prosthetic group: a method comparable to direct fluorination, F. Basuli et al., J. Labelled Comp. Radiopharm., 60(3), 168–175(2017); DOI: 10.1002/jlcr.3487.
  3. Induction of genes implicated in stress response and autophagy by a novel quinolin-8-yl-nicotinamide QN532 in pancreatic cancer, Y. Kuang et al., J. Med. Chem., 65(8), 6133–6156(2022); DOI: 10.1021/acs.jmedchem.1c02207.
  4. Structural and spectroscopic characteristics of NiII and CuII complexes with poly(vinyl alcohol-nicotinic acid) copolymers for photocatalytic degradation of indigo carmine dye, I. Ali et al., Crystals, 11, 1244(2021); DOI: 10.3390/cryst11101244.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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