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CAS Number 103438-88-6

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers

Product Code B2731-5g
Price £137 ex. VAT

A fluorinated benzaldehyde building block

Utilised as a key precursor for drug discoveries

Specifications | MSDS | Literature and Reviews

2-Fluoro-3-methoxybenzaldehyde (CAS number 103438-88-6) is a benzaldehyde building block, bearing a fluoride and a methoxy at 2- and 3-positions. 2-Fluoro-3-methoxybenzaldehyde finds widespread use as a precursor for active pharmaceutical ingredients (APIs), particularly in the synthesis of benzosuberone derivatives. To construct benzosuberone cores, 2-fluoro-3-methoxybenzaldehyde reacts with (3-carboxypropyl)triphenylphosphonium bromide through a Wittig reaction. The formation of cycloheptanone ring is achieved through a Friedel-Craft acylation using Eaton's reagent (phosphorus pentoxide and methanesulfonic acid).

2-Fluoro-3-methoxybenzaldehyde is also employed in the synthesis of bicyclic heterocycles, including hydroisoquinolines, acrydinone and quinazolines.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzaldehyde building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 103438-88-6

High purity

>98% High purity

General Information

CAS Number 103438-88-6
Chemical Formula C8H7FO2
Full Name 2-Fluoro-3-methoxybenzaldehyde
Molecular Weight 154.14 g/mol
Synonyms 2-Fluoro-m-anisaldehyde
Classification / Family Fluorinated building blocks, Benzaldehyde building blocks, Heterocycles, APIs

Chemical Structure

2-Fluoro-3-methoxybenzaldehyde chemical structure, CAS 103438-88-6.
2-Fluoro-3-methoxybenzaldehyde chemical structure, CAS 103438-88-6

Product Details

Purity 98%
Melting Point Tm = 47 °C – 51 °C
Appearance White crystals

MSDS Documentation

2-Fluoro-3-methoxybenzaldehyde2-Fluoro-3-methoxybenzaldehyde MSDS Sheet

Literature and Reviews

  1. Synthesis and pharmacological evaluation of 1-isopropyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel antihypertensive agents, S. Watanuki et al., Chem. Pharm. Bull., 59(8), 1029–1037(2011); DOI: 10.1248/cpb.59.1029.
  2. Introducing telescoping process to synthesis of a key intermediate of drug discoveries using design of experiment,K. Nishimura et al., Chem. Pharm. Bull., 64, 1043–1046(2016), DOI: 10.1248/cpb.c16-00187.
  3. Synthesis of o-(dimethylamino)aryl ketones acridones, acridinium salts, and 1H-indazoles by the reaction of hydrazone and arynes, A. Dubrovskiy et al., J. Org. Chem., 77(24), 11232–11256(2012); DOI: 10.1021/jo302378w.
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