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Product Code B2221-25g
Price $132 ex. VAT

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A di-halogenated pyridine derivative

Applied as a molecular scaffold for APIs in drug discovery and semiconductors intermediates in OLEDs


5-Bromo-2-fluoropyridine (CAS number 766-11-0) is a halogenated pyridine bearing a bromine and a fluorine at 5- and 2-positions. 5-Bromo-2-fluoropyridine has been used as a molecular scaffold for many active pharmaceutical ingredients(APIs) such as inhibitors of neuropeptide Y receptor Y5, inhibitors of the main protease of SARS-CoV-2 and inhibitors of indoleamine-2,3-dioxygenase-1 in cancer immunotherapy. The bromine and fluorine substituents have different reactivity. Fluorine substituent is in favour of nucleophilic aromatic substitution, while bromine substituent prefers copper/palladium catalysed C-C/C-N coupling.

5-Bromo-2-fluoropyridine is also an ideal building block for semiconductors, due to its aromaticity and electron deficiency. A host material of 5-(5-(2,4,6-triiso-propylphenyl)pyridin-2-yl)-5H-benzo[d]benzo-[4,5]imidazo[1,2-a]imidazole is synthesized from 5-bromo-2-fluoropyridine for OLED applications.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated pyridine building block

For drug discovery, organic synthesis, OLEDs research

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High purity 766-11-0

High purity

>98% High purity

General Information

CAS Number 766-11-0
Chemical Formula C5H3BrFN
Full Name 5-Bromo-2-fluoropyridine
Molecular Weight 175.99 g/mol
Synonyms 3-Bromo-6-fluoropyridine
Classification / Family Fluorinated building block, Heterocyclic building block, Pyridine derivatives, Drug discovery, APIs, OLEDs

Chemical Structure

5-Bromo-2-fluoropyridine chemical structure, CAS 766-11-0
5-Bromo-2-fluoropyridine chemical structure, CAS 766-11-0

Product Details

Purity 98%
Boiling Point Tb = 162 – 164 °C at 760 mmHg
Relative Density 1.71 g/mL at 25 °C
Appearance Colourless liquid

MSDS Documentation

5-Bromo-2-fluoropyridine5-Bromo-2-fluoropyridine MSDS Sheet

Literature and Reviews

  1. Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor, M. Ando et al., Bioorg. Med. Chem., 17, 6106–6122(2009); DOI: 10.1016/j.bmc.2009.05.069.
  2. Highly twisted donor-acceptor boron emitter and high triplet host material for highly efficient blue thermally activated delayed fluorescent device, D. Ahn et al., ACS Appl. Mater. Interfaces, 11(16), 14909–14916(2019); DOI: 10.1021/acsami.9b00931.
  3. Metal-free site-selective C–N bond-forming reaction of polyhalogenated pyridines and pyrimidines, L. Wang et al., RSC Adv., 5, 82097–82111(2015); DOI: 10.1039/C5RA18653F.
  4. Optimization of triarylpyridinone inhibitors of the main protease of SARS-CoV-2 to low-nanomolar antiviral potency, C. -H. Zhang et al., ACS Med. Chem. Lett. 12, 1325−1332(2021); DOI: 10.1021/acsmedchemlett.1c00326.
  5. Strategic incorporation of polarity in heme-displacing inhibitors of indoleamine-2,3-dioxygenase-1(IDO1), C. White et al., ACS Med. Chem. Lett., 11, 550−557(2020); DOI: 10.1021/acsmedchemlett.0c00010.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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