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Product Code B2781-5g
Price £90 ex. VAT

A difluorinated pyridine building block

Serves as a precursor for APIs and TDAF emitters

Specifications | MSDS | Literature and Reviews

3,5-Difluoropyridine-2-carbonitrile (CAS number 298709-29-2), also knowns as 3,5-difluoropicolinonitrile, is a difluorinated cyanopyridine. 3,5-Difluoropyridine-2-carbonitrile is highly electron deficient, thus the fluorine substituents readily undergo nucleophilic aromatic substitution reactions. A thermally activated delayed fluorescence (TADF) emitter, known as 2,4-2(9H-carbazol-9-yl)-1-cyano-pyridine, is prepared using this method, demonstrating maximum current, power and external quantum efficiency values of 27.5 cdA-1, 25.6 lmW-1 and 9.1%, respectively, in OLED application.

3,5-Difluoropyridine-2-carbonitrile finds extensive applications as a molecular scaffold in medicinal chemistry such as the synthesis of thiazole analogues for desferrithiocin.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated picolinonitrile building block

For drug discovery, TADF dyes and biochemistry research

Worldwide shipping for 298709-29-2

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High purity 298709-29-2

High purity

>97% High purity

General Information

CAS Number 298709-29-2
Chemical Formula C6H2F2N2
Full Name 3,5-Difluoropyridine-2-carbonitrile
Molecular Weight 140.09 g/mol
Synonyms 3,5-Difluoropicolinonitrile, 2-Cyano-3,5-difluoropyridine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, APIs, OlEDs, TDAF

Chemical Structure

3,5-Difluoropyridine-2-carbonitrile chemical structure, CAS 298709-29-2.
3,5-Difluoropyridine-2-carbonitrile chemical structure, CAS 298709-29-2

Product Details

Purity 97%
Melting Point Tm = 30 °C – 34 °C
Appearance White crystals

MSDS Documentation

3,5-Difluoropyridine-2-carbonitrile3,5-Difluoropyridine-2-carbonitrile MSDS Sheet

Literature and Reviews

  1. Carbazole/a-carboline hybrid bipolar compounds as electron acceptors in exciplex or non-exciplex mixed cohosts and exciplex-TADF emitters for high-efficiency OLEDs, Q. Wu et al., J. Mater. Chem. C, 6, 8784(2018); DOI: 10.1039/c8tc02353k.
  2. Structure−activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of Haemonchus contortus development, T. Le et al., J. Med. Chem., 62(2), 1036–1053(2019); DOI: 10.1021/acs.jmedchem.8b01789.
  3. Desferrithiocin: a search for clinically effective iron chelators, R. Bergeron et al., J. Med. Chem. 57, 9259–9291(2014); DOI: 10.1021/jm500828f.
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