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3-Fluoro-4-hydroxybenzaldehyde

CAS Number 405-05-0

Fluorinated Building Blocks, Monomers


Product Code B2591-5g
Price $100 ex. VAT

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A fluorinated benzaldehyde building block

Used as a synthesis intermediate for chalcones and curcumins in application of pharmaceutical active ingredients


3-Fluoro-4-hydroxybenzaldehyde (CAS number 405-05-0) is a fluorinated benzaldehyde bearing a fluorine and a hydroxy at 3- and 4-positions. 3-Fluoro-4-hydroxybenzaldehyde is used to synthesise analogues of curcuminoid with ketones through aldol condensation. The as synthesised curcuminoid derivatives show half maximal inhibitory concentration of 0.75 μM against human ovarian cancer cell line A2780. Hydrazone derivatives can be obtained from 3-fluoro-4-hydroxybenzaldehyde with a phenylhydrazine derivatives via aldehyde-amine condensation, showing potent inhibitory of macrophage migration in anti-inflammatory activity.

3-Fluoro-4-hydroxybenzaldehyde is also exploited to synthesise caffeic acid phenylethyl amide derivatives through Wittig reaction for cytoprotective activity against peroxides.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzaldehyde building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 405-05-0

High purity

>97% High purity

General Information

CAS Number 405-05-0
Chemical Formula C7H5FO2
Full Name 3-Fluoro-4-hydroxybenzaldehyde
Molecular Weight 140.11 g/mol
Synonyms 2-Fluoro-4-formylphenol
Classification / Family Fluorinated building blocks, Benzaldehyde building blocks, APIs

Chemical Structure

3-Fluoro-4-hydroxybenzaldehyde chemical structure, CAS 405-05-0.
3-Fluoro-4-hydroxybenzaldehyde chemical structure, CAS 405-05-0

Product Details

Purity 97%
Melting Point Tm = 121 °C – 124 °C
Appearance Beige powder

MSDS Documentation

3-Fluoro-4-hydroxybenzaldehyde3-Fluoro-4-hydroxybenzaldehyde MSDS Sheet

Literature and Reviews

  1. Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: Comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE), J. Yang et al., Bioorg. Med. Chem., 18, 5032–5038(2010); DOI: 10.1016/j.bmc.2010.05.080.
  2. Novel arylazoarylmethane as potential inhibitor of macrophage migration inhibitory factor, M. He et al., Arch. Pharm. Chem. Life Sci., 346, 1–4(2013); DOI: 10.1002/ardp.201300243.
  3. Enzymatic Baeyer-Villiger Oxidation of Benzaldehydes, M. Moonen et al., Adv. Synth. Catal., 347, 1027–1034(2005); DOI: 10.1002/adsc.200404307.
  4. Phenolic hydrazones are potent inhibitors of macrophage migration inhibitory factor proinflammatory activity and survival improving agent in sepsis, D. Dabideen et al., J. Med. Chem., 50(8), 1993–1997(2007); DOI: 10.1021/jm061477+.
  5. Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells, H. Patel et al., Med. Chem. Res., 29, 935–341(2020); DOI: 10.1007/s00044-020-02532-5.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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