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3-Fluoro-4-hydroxybenzaldehyde

CAS Number 405-05-0

Fluorinated Building Blocks, Materials, Monomers


Product Code B2591-5g
Price £80 ex. VAT

A fluorinated benzaldehyde building block

Used as a synthesis intermediate for chalcones and curcumins in application of pharmaceutical active ingredients


Specifications | MSDS | Literature and Reviews


3-Fluoro-4-hydroxybenzaldehyde (CAS number 405-05-0) is a fluorinated benzaldehyde bearing a fluorine and a hydroxy at 3- and 4-positions. 3-Fluoro-4-hydroxybenzaldehyde is used to synthesise analogues of curcuminoid with ketones through aldol condensation. The as synthesised curcuminoid derivatives show half maximal inhibitory concentration of 0.75 μM against human ovarian cancer cell line A2780. Hydrazone derivatives can be obtained from 3-fluoro-4-hydroxybenzaldehyde with a phenylhydrazine derivatives via aldehyde-amine condensation, showing potent inhibitory of macrophage migration in anti-inflammatory activity.

3-Fluoro-4-hydroxybenzaldehyde is also exploited to synthesise caffeic acid phenylethyl amide derivatives through Wittig reaction for cytoprotective activity against peroxides.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated benzaldehyde building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 405-05-0

High purity

>97% High purity

General Information


CAS Number 405-05-0
Chemical Formula C7H5FO2
Full Name 3-Fluoro-4-hydroxybenzaldehyde
Molecular Weight 140.11 g/mol
Synonyms 2-Fluoro-4-formylphenol
Classification / Family Fluorinated building blocks, Benzaldehyde building blocks, APIs

Chemical Structure


3-Fluoro-4-hydroxybenzaldehyde chemical structure, CAS 405-05-0.
3-Fluoro-4-hydroxybenzaldehyde chemical structure, CAS 405-05-0

Product Details


Purity 97%
Melting Point Tm = 121 °C – 124 °C
Appearance Beige powder

MSDS Documentation


3-Fluoro-4-hydroxybenzaldehyde3-Fluoro-4-hydroxybenzaldehyde MSDS Sheet

Literature and Reviews


  1. Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: Comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE), J. Yang et al., Bioorg. Med. Chem., 18, 5032–5038(2010); DOI: 10.1016/j.bmc.2010.05.080.
  2. Novel arylazoarylmethane as potential inhibitor of macrophage migration inhibitory factor, M. He et al., Arch. Pharm. Chem. Life Sci., 346, 1–4(2013); DOI: 10.1002/ardp.201300243.
  3. Enzymatic Baeyer-Villiger Oxidation of Benzaldehydes, M. Moonen et al., Adv. Synth. Catal., 347, 1027–1034(2005); DOI: 10.1002/adsc.200404307.
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