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Product Code B3321-5g
Price $44 ex. VAT

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A fluorinated acetophenone building block

As a synthesis intermediate for APIs


4′-Fluoro-3′-nitroacetophenone (CAS number 400-93-1) is a derivative of acetophenone with fluoride and nitro substituents. With its three functional groups, 4′-fluoro-3′-nitroacetophenone commonly serves as a molecular scaffold for active pharmaceutical ingredients. An inhibitor of Trypanosoma cruzi (Tc, causing Chagas disease) is synthesized from 4′-fluoro-3′-nitroacetophenone through a series of reactions, including nucleophilic aromatic substitution on the fluoride group, amination on the ketone and reduction on the nitro group. The resulting product shows promising efficacy in Tc infection with a potency of 8 nM.

4′-Fluoro-3′-nitroacetophenone is also utilised for the synthesis of bicyclic heterocycles, such as chromen derivatives.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated nitroacetophenone building block

Fluorinated nitroacetophenone building block

For drug discovery, medicinal chemistry, and biochemistry

competitively priced 400-93-1

Low Cost

Competitively priced, high quality product

High purity 400-93-1

High purity

>98% High purity

General Information

CAS Number 400-93-1
Chemical Formula C8H6FNO3
Full Name 1-(4-Fluoro-3-nitrophenyl)ethanone
Molecular Weight 183.14 g/mol
Synonyms 3-Acetyl-6-fluoronitrobenzene, 4-Acetyl-1-fluoro-2-nitrobenzene
Classification / Family Fluorinated building blocks, Nitro building blocks, Acetophenone building blocks, APIs

Chemical Structure

4′-Fluoro-3′-nitroacetophenone chemical structure, CAS 400-93-1
4′-Fluoro-3′-nitroacetophenone chemical structure, CAS 400-93-1

Product Details

Purity 98%
Melting Point Tm = 47 °C – 51 °C
Appearance Light brown crystals

MSDS Documentation

4′-Fluoro-3′-nitroacetophenone4′-Fluoro-3′-nitroacetophenone MSDS Sheet

Literature and Reviews

  1. Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity, B. Xu et al., Eur. J. Med. Chem., 214, 113225 (2021); DOI: 10.1016/j.ejmech.2021.113225.
  2. Synthesis and anticancer study of novel 4H-chromen derivatives, X. Lu et al., Anticancer Agents Med. Chem., 17 (8), 1070–1083 (2023); DOI: 10.2174/1871520615666160504094945.
  3. Defect-mediated selective hydrogenation of nitroarenes on nanostructured WS2, Y. Sun et al., Chem. Sci., 10, 10310 (2019); DOI: 10.1039/c9sc03337h.
  4. Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi, Future Med. Chem., 5 (15), 1733–1752 (2013); DOI: 10.4155/FMC.13.139.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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