4′-Fluoro-3′-nitroacetophenone

A fluorinated acetophenone building block

As a synthesis intermediate for APIs

Specifications | MSDS | Literature and Reviews

4′-Fluoro-3′-nitroacetophenone (CAS number 400-93-1) is a derivative of acetophenone with fluoride and nitro substituents. With its three functional groups, 4′-fluoro-3′-nitroacetophenone commonly serves as a molecular scaffold for active pharmaceutical ingredients. An inhibitor of Trypanosoma cruzi (Tc, causing Chagas disease) is synthesized from 4′-fluoro-3′-nitroacetophenone through a series of reactions, including nucleophilic aromatic substitution on the fluoride group, amination on the ketone and reduction on the nitro group. The resulting product shows promising efficacy in Tc infection with a potency of 8 nM.

4′-Fluoro-3′-nitroacetophenone is also utilised for the synthesis of bicyclic heterocycles, such as chromen derivatives.

Multiple functional groups

For facile synthesis

Fluorinated nitroacetophenone building block

For drug discovery, medicinal chemistry, and biochemistry

Low Cost

Competitively priced, high quality product

High purity

>98% High purity

General Information

Chemical Structure

Product Details

MSDS Documentation

4′-Fluoro-3′-nitroacetophenone MSDS Sheet

Literature and Reviews

1. Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity, B. Xu et al., Eur. J. Med. Chem., 214, 113225 (2021); DOI: 10.1016/j.ejmech.2021.113225.
2. Synthesis and anticancer study of novel 4H-chromen derivatives, X. Lu et al., Anticancer Agents Med. Chem., 17 (8), 1070–1083 (2023); DOI: 10.2174/1871520615666160504094945.
3. Defect-mediated selective hydrogenation of nitroarenes on nanostructured WS₂, Y. Sun et al., Chem. Sci., 10, 10310 (2019); DOI: 10.1039/c9sc03337h.

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