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Product Code B3921-250mg
Price $100 ex. VAT

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Covalent Organic Frameworks (COFs) Terphenyl Ligand

An aldehyde fluoro functionalised bridging ligand linker for COFs in application of fluorescence probe sensors, membrane, and detection of dopamine


Trigonal 1,3,5-tris(3-fluoro-4-formylphenyl)benzene (TFFPB), CAS number 2088007-04-7, has a chemical structure of three 3-fluoro-4-formylphenyl groups sitting at the meta positions of a benzene ring. The aldehyde groups help to extend the structure to frameworks by forming covalent bonding and the fluoro-groups enhance the richness of the fluorine content of the targeted structures.

Constructed from 1,3,5-tris(4-aminophenyl) benzene (TPB) and 1,3,5-tri(3-fluoro-4-formylphenyl) benzene as the building elements at room temperature, porous covalent organic framework TPTF-COF is fluorine-rich, highly crystalline and thermally stable with rich functional group properties and large specific surface area of 1084.61 m2·g−1.

Containing 1,3,5-tris(3-fluoro-4-formylphenyl)benzene nodes and acrylonitrile linkages, smart COF showed rapid pH-responsive absorption and fluorescence, high fluorescence quantum yield, and good crystallinity. It exhibited a 20% enhancement in fluorescence quantum yield and more rapid sensitivity of absorption and fluorescence under acid–base induction compared to its nonfluorinated counterpart.

MOF and COF ligands

MOF and COF ligands

Fluoride and aldehyde ligand for cross-linked COF networks

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High purity 2088007-04-7

High purity

>98% High purity

Duo functionality

Duo functionality

Enabling post-functionalisation

General Information

CAS Number 2088007-04-7
Chemical Formula C27H15F3O3
Full Name 1,3,5-Tris(3-fluoro-4-formylphenyl)benzene
Molecular Weight 444.40 g/mol
Synonyms TFFPB, 3,3''-Difluoro-5'-(3-fluoro-4-formylphenyl)-[1,1':3',1''-terphenyl]-4,4''-dicarbaldehyde
Classification / Family Terphenyls, COF ligands, Fluorinated building blocks

Chemical Structure

2088007-04-7 - 1,3,5-tris(3-fluoro-4-formylphenyl)benzene chemical structure
1,3,5-Tris(3-fluoro-4-formylphenyl)benzene (TFFPB) Chemical Structure, 2088007-04-7.

Product Details

Purity >98%
Melting Point N/A
Appearance White to yellow to orange powder/crystals

MSDS Documentation

2088007-04-7 - 1,3,5-tris(3-fluoro-4-formylphenyl)benzene1,3,5-Tris(3-fluoro-4-formylphenyl)benzene MSDS Sheet

Literature and Reviews

  1. Acrylonitrile-Linked Covalent Organic Frameworks Enable Fast Stimulus-Responsive Fluorescence with High Quantum Yield via Fluorine Chemistry, M. Yang et al., Adv. Photonic Res., 3 (8), 2200008 (2022); DOI: 10.1002/adpr.202200008.
  2. Fluorine-Containing Covalent Organic Frameworks: Synthesis and Application, W. Li et al., Macromol. Rapid Commun., 44 (11), 2200778 (2023); DOI: 10.1002/marc.202200778.
  3. Fabrication of high-crystallinity covalent organic framework and its nylon based membrane: Application in the enrichment and interception of dyes, J. Wong et al., J. Environ. Chem. Eng., 11, 110989 (2023); DOI: 10.1016/j.jece.2023.110989.
  4. Covalent organic frameworks: an ideal platform for designing ordered materials and advanced applications, R. Liu et al., Chem. Soc. Rev., 50, 120 (2021); DOI: 10.1039/d0cs00620c.
  5. Fluoro-Substituted Covalent Organic Framework Particles Anchored on TiO2 Nanotube Arrays for Photoelectrochemical Determination of Dopamine, C. Wang et al., ACS Appl. Nano Mater., 4 (9), 8801–8812 (2021); DOI: 10.1021/acsanm.1c01466.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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