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Product Code B3521-1g
Price £140 ex. VAT

Covalent organic frameworks (COFs) hexaphenylbenzene ligand

a C6 symmetric ligand for synthesising controllable microporous COFs


Specifications | MSDS | Literature and Reviews


Hexa(4-formylphenyl)benzene (CAS number 1862220-96-9) is a ligand featuring a hexaphenylbenzene core and six aldehyde groups. Hexa(4-formylphenyl)benzene is a C6 rotational symmetric ligand. This ligand is used in the construction of 2D COFs with various tiling topologies, including triangular, rhombille, and kagome, depending on the choice of linkers used in the reaction. The resulting 2D COFs have controllable pore sizes, offering short molecular diffusion length and facilitating host-guest interactions for drug delivery.

A COF with azine linkages can be prepared from hexa(4-formylphenyl)benzene and hydrazine. The resulting COF has high surface area exceeding 1200 m2/g, with an average pore size of 1 nm. It also demonstrates excellent performance of CO2 and methane uptakes, with capacities of 20 wt% and 2.3 wt%, respectively.

Facile reactions

Facile reactions

Aldehyde possesses excellent reactivity

High Purity 1862220-96-9

High Purity

>98% Purity

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MOF and COF ligands

MOF and COF ligands

Aldehyde ligand for cross-linked COF networks

General Information


CAS Number 1862220-96-9
Chemical Formula C48H30O6
Full Name 3',4',5',6'-Tetrakis(4-formylphenyl)-[1,1'2',1''-terphenyl]-4,4''-dicarbaldehyde
Molecular Weight 702.75 g/mol
Synonyms Hexa(4-formylphenyl)benzene, HFBP, 4-[2,3,4,5,6-pentakis(4-formylphenyl)phenyl]benzaldehyde
Classification / Family Hexaphenylbenzenes, COFs, Aldehyde ligands, Porous, CO2 sorption, Drug delivery

Chemical Structure


Hexa(4-formylphenyl)benzene  chemical structure, CAS 1862220-96-9.
Hexa(4-formylphenyl)benzene chemical structure, CAS 1862220-96-9

Product Details


Purity 98%
Melting Point N/A
Appearance White powder

MSDS Documentation


Hexa(4-formylphenyl)benzeneHexa(4-formylphenyl)benzene MSDS Sheet

Literature and Reviews


  1. An azine-linked hexaphenylbenzene based covalent organic framework, S. Alahakoon et al., Chem. Commun., 52, 2843–2845 (2016); DOI: 10.1039/C5CC10408D.
  2. Rational design of two-dimensional covalent tilings using a C6-symmetric building block via on-surface Schiff base reaction, C. Lu et al., Chem. Commun., 55, 1326–1329 (2019); DOI: 10.1039/C8CC08801B.
  3. Isoreticular series of two-dimensional covalent organic frameworks with the kgd topology and controllable micropores, L. Li et al., J. Am. Chem. Soc., 144 (14), 6475–6482 (2022); DOI: 10.1021/jacs.2c01199.
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