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5,5'-(Ethyne-1,2-diyl)diisophthalaldehyde

CAS Number 2237965-02-3

Carbaldehyde Monomers, Chemistry Building Blocks, COF Ligands, Monomers, Porous Organic Frameworks


Product Code B3611-500mg
Price $200 ex. VAT

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Covalent organic frameworks (COFs) diphenylacetylene ligand

Used in the synthesis of COFs cages for porous materials and molecular motors


5,5'-(Ethyne-1,2-diyl)diisophthalaldehyde (CAS number 2237965-02-3), is a diphenylacetylene ligand featuring four aldehyde groups. It is utilized in the synthesis of COFs and porous organic cages for porous materials applications. For example, when 5,5'-(ethyne-1,2-diyl)diisophthalaldehyde reacts with cyclohexane-1,2-diamine, [3+6] trigonal prism cages are formed. These resulting cages can undergo reversible transformation into [6+12] truncated tetrahedron cages, thereby leading to variations in pore sizes.

5,5'-(Ethyne-1,2-diyl)diisophthalaldehyde is also employed in the synthesis of dumbbell-shaped macro-cages, cooperating with tri-topic amines and di-topic aldehydes. These organic cage dumbbells showcase a triphenylacetylene core at the centre, enabling unrestricted rotation of each end of the dumbbells. Hence, its potential for application in molecular motor research is promising.

Facile reactions

Facile reactions

Aldehyde possesses excellent reactivity

High Purity 2237965-02-3

High Purity

>98% Purity

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MOF and COF ligands

MOF and COF ligands

Aldehyde ligand for cross-linked COF networks

General Information

CAS Number 2237965-02-3
Chemical Formula C18H10O4
Full Name 5,5'-(1,2-Ethynediyl)diisophthalaldehyde
Molecular Weight 290.3 g/mol
Synonyms 5-[2-(3,5-Diformylphenyl)ethynyl]benzene-1,3-dicarbaldehyde
Classification / Family COFs, CMPs, Porous materials, Molecular motors

Chemical Structure

5,5'-(Ethyne-1,2-diyl)diisophthalaldehyde chemical structure, CAS 2237965-02-3.
5,5'-(Ethyne-1,2-diyl)diisophthalaldehyde chemical structure, CAS 2237965-02-3

Product Details

Purity 98%
Melting Point Tm = 209 °C – 211 °C
Appearance Yellow powder

MSDS Documentation

5,5'-(Ethyne-1,2-diyl)diisophthalaldehyde5,5'-(Ethyne-1,2-diyl)diisophthalaldehyde MSDS Sheet

Literature and Reviews

  1. Post-synthetic modification of porous organic cages, H. Wang et al., Chem. Soc. Rev., 50, 8874–8886 (2021); DOI: 10.1039/D0CS01142H.
  2. Reticular synthesis of porous molecular 1D nanotubes and 3D networks, A. Slater et al., Nature Chem., 9, 17–25 (2017); DOI: 10.1038/nchem.2663.
  3. Organic Cage Dumbbells, R. Greenaway et al., Chem. Eur. J., 26, 3718 (2020); DOI: 10.1002/chem.201905623.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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