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4',4''',4'''''-Nitrilotris([1,1'-biphenyl]-4-carbaldehyde)

CAS Number 872689-79-7

Carbaldehyde Monomers, Chemistry Building Blocks, COF Ligands, Materials, Monomers, Porous Organic Frameworks


Product Code B3801-500mg
Price $113 ex. VAT

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Covalent Organic Frameworks (COFs) Triarylamine Ligand

A formyl functional ligand linker for COFs in application of carbon dioxide adsorption, photocatalysts and sensors


4',4''',4'''''-Nitrilotris([1,1'-biphenyl]-4-carbaldehyde) (NTBCA) has a triangular structure with triarylamine core and three aldehyde functional groups. The triarylamine core is electron rich and the aldehyde groups condense with amines to form imine linkages in covalent organic framework (COFs).

Covalent organic framework HAT-NTBCA-COF, featuring [C6 + C3] symmetric units of propeller-like hexaamino-hexaazatriphenylene ([NH2]6HAT) nodes and triangular symmetric linker NTBCA with imine linkages showed high thermal stability with CO2 uptakes of HAT-NTBCA-COF being 6.0 wt% (273 K) and 3.7 wt% (298 K).

[3 + 4] condensation reaction forming imine linkages between triangular 4′,4′″,4′″″-nitrilotris([1,1′-biphenyl]-4-carbaldehyde) with rectangular 4,4′,4″,4′″-(ethene-1,1,2,2-tetrayl)tetraaniline gave COF-1. With great thermal and chemical stability, COF-1 served as efficient photocatalyst for the cross-dehydrogenative coupling reaction and also the asymmetric α-alkylation of aldehydes integrated with a MacMillan imidazolidinone as the chiral catalyst under visible light.

MOF and COF ligands

MOF and COF ligands

Aldehyde ligand for cross-linked COF networks

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High purity 872689-79-7

High purity

>98% High purity

Facile reactions

Facile reactions

Aldehyde possesses excellent reactivity

General Information

CAS Number 872689-79-7
Chemical Formula C39H27NO3
Full Name 4',4''',4'''''-Nitrilotris([1,1'-biphenyl]-4-carbaldehyde)
Molecular Weight 557.64 g/mol
Synonyms NTCBA, [1,1-Biphenyl]-4-carboxaldehyde,4-[bis(4-formyl[1,1-biphenyl]-4-yl)amino]-
Classification / Family Triarylamine, COF ligands

Chemical Structure

872689-79-7 - 4',4''',4'''''-nitrilotris([1,1'-biphenyl]-4-carbaldehyde) chemical structure
4',4''',4'''''-Nitrilotris([1,1'-biphenyl]-4-carbaldehyde) (NTBCA) Chemical Structure, 872689-79-7

Product Details

Purity >98%
Melting Point N/A
Appearance Yellow to orange powder/crystals

MSDS Documentation

872689-79-7 - 4',4''',4'''''-nitrilotris([1,1'-biphenyl]-4-carbaldehyde)4',4''',4'''''-Nitrilotris([1,1'-biphenyl]-4-carbaldehyde) MSDS Sheet

Literature and Reviews

  1. Construction of 2D covalent organic frameworks by taking advantage of the variable orientation of imine bonds, S. Xu et al., Chem. Commun., 53, 2431-2434 (2017); DOI: 10.1039/C6CC09906H.
  2. Rational synthesis of interpenetrated 3D covalent organic frameworks for asymmetric photocatalysis, X. Kang et al., Chem. Sci., 11, 1494-1502 (2020); DOI: 10.1039/C9SC04882K.
  3. Precision Construction of 2D Heteropore Covalent Organic Frameworks by a Multiple-Linking-Site Strategy, C. Qian et al., 22 (49), 17784-17789 (2016); DOI: 10.1002/chem.201603043.
  4. Nitrogen-rich covalent organic frameworks: a promising class of sensory materials, H. Bhambri et al., Mater. Adv., 3, 19-124 (2022); DOI: 10.1039/D1MA00506E.
  5. Reticular Synthesis of tbo Topology Covalent Organic Frameworks, X. Kang et al., J. Am. Chem. Soc., 142, 38, 16346–16356 (2020); DOI: 10.1021/jacs.0c06605.
  6. Covalent Organic Frameworks: From Structures to Applications, Q. tran et al., Polymers, 15(5), 1279 (2023); DOI: 10.3390/polym15051279.
  7. Macrocycle-Based Covalent Organic Frameworks, Y. Yuan et al., 35 (16), 2210952 (2023); DOI: 10.1002/adma.202210952.
  8. Covalent Organic Frameworks: Structures, Synthesis, and Applications, M. Lohse et al., Adv. Funct. Mater., 28 (33), 1705553 (2018); DOI: 10.1002/adfm.201705553.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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