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Product Code B3541-500mg
Price $185 ex. VAT

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Covalent organic frameworks (COFs) bipyridine ligands

for synthesising COFs and their metal complexes for host-guest interactions


[3,3-Bipyridine]-6,6-dicarboxaldehyde, also known under IUPAC name of 3,3'-bipyridine-6,6'-dicarbaldehyde, is a derivative of 3,3’-bipyridine functionalised with two aldehyde groups. [3,3-Bipyridine]-6,6-dicarboxaldehyde undergoes reactions with amines to synthesise Schiff bases. The formation of the imine on the meso-carbon and the imine in the pyridine ring can coordinate to metal centre constructing a stable 5-membered ring. A metal-organic polyhedra composed of FeII and the Schiff base ligand prepared from [3,3-bipyridine]-6,6-dicarboxaldehyde and aniline, exhibits selective anion binding to PF6- over CF3SO3- and BF4-.

The metal-organic complexes from [3,3-bipyridine]-6,6-dicarboxaldehyde based COFs display a reversible binding affinity towards fluorescent dyes. This property enables the design of indicator-displacement assays.

Facile reactions

Facile reactions

Aldehyde possesses excellent reactivity

High Purity 1264748-06-2

High Purity

>98% Purity

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MOF and COF ligands

MOF and COF ligands

Aldehyde ligand for cross-linked COF networks

General Information

CAS Number 1264748-06-2
Chemical Formula C12H8N2O2
Full Name 3,3'-Bipyridine-6,6'-dicarbaldehyde
Molecular Weight 212.20 g/mol
Synonyms 5-(6-formyl-3-pyridyl)pyridine-2-carbaldehyde
Classification / Family Bipyridine ligands, Aldehydes, COFs, MOFs, Host-guest interactions

Chemical Structure

[3,3-Bipyridine]-6,6-dicarboxaldehyde chemical structure, CAS 1264748-06-2.
[3,3-Bipyridine]-6,6-dicarboxaldehyde chemical structure, CAS 1264748-06-2

Product Details

Purity 98%
Melting Point N/A
Appearance Brown powder

MSDS Documentation

[3,3-Bipyridine]-6,6-dicarboxaldehyde[3,3-Bipyridine]-6,6-dicarboxaldehyde MSDS Sheet

Literature and Reviews

  1. Aqueous anion receptors through reduction of subcomponent self-assembled structures, J. Mosquera et al., Angew. Chem. Int. Ed., 53, 1556–1559 (2014); DOI: 10.1002/anie.201308117.
  2. Selective anion binding by a "Chameleon" capsule with a dynamically reconfigurable exterior, Y. Hristova et al., Chem. Sci., 2, 638 (2011); DOI: 10.1039/c0sc00495b.
  3. Dynamic imine chemistry in metal-organic polyhedra, H. Vardhan et al., RSC Adv., 5, 67011–67030 (2015); DOI: 10.1039/C5RA10801B.
  4. A dynamic-covalent, luminescent metallopolymer that undergoes sol-to-gel transition on temperature rise, X. Hatten et al., J. Am. Chem. Soc., 133(9), 3158–3164 (2011); DOI: 10.1021/ja110575s.
  5. Synthesis of contra-helical trefoil knots with mechanically tuneable spin-crossover properties, L. Wu et al., Nat. Synth., 2, 17–25 (2023); DOI: 10.1038/s44160-022-00173-7.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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