FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on info@ossila.com, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.

5''-(4'-Formyl-[1,1'-biphenyl]-4-yl)-[1,1':4',1'':3'',1''':4''',1''''-quinquephenyl]-4,4''''-dicarbaldehyde

CAS Number 805246-78-0

Carbaldehyde Monomers, COF Ligands, Materials, Porous Organic Frameworks


Product Code B4591-1g
Price £80 ex. VAT

Covalent Organic Frameworks (COFs) Quinquephenyl Ligand

A trigonal bridging ligand linker for covalent organic frameworks (COFs) in application of photocatalysts for hydrogen evolution reactions (HERs), hydrochloric acid and ammonia vapor sensing, and anticancer activity


Specifications | MSDS | Literature and Reviews


5''-(4'-Formyl-[1,1'-biphenyl]-4-yl)-[1,1':4',1'':3'',1''':4''',1''''-quinquephenyl]-4,4''''-dicarbaldehyde (TFBPB) has a trigonal structure with three 4-formyl-[1,1'-biphenyl] units attached to a central benzene ring at 1,3,5-positions.

With the combination of efficient light harvesting capability of a suitable band gap and catalytic sites, covalent organic framework TFBPB-TAT-COF with D-A type alternating units of TFBPB and 2,4,6-tris(4-aminophenyl)-1,3,5-triazine shows promise as an ideal photo absorber and photocatalyst for hydrogen revolution reactions (HERs). TFBPB-TAT-COF also shows excellent anticancer activity for human colorectal carcinoma HCT-116 cells.

MOF and COF ligands

MOF and COF ligands

Ethene ligand for cross-linked COF networks

Worldwide shipping for 910231-21-9

Worldwide shipping

Quick and reliable shipping

High purity 910231-21-9

High purity

>97% High purity

Facile reactions

Facile reactions

Readily for polycondensation reaction to form imine or double bond linkages

Vinyl tetrazine-linked covalent organic frameworks TA-COF-2, obtained from Knoevenagel condensation reaction between 3,6-bis((E)-2-([1,1'-biphenyl]-4-yl)vinyl)-1,2,4,5-tetrazine and TFBPB, demonstrates high crystallinity and specific surface areas of 1114 m2 g−1 with favourable band gaps and position as photocatalyst in the arylboronic acids oxidation and light-induced coupling of benzylamines. TA-COF-2 also shows sensing capability with reversible colour changes upon exposure to HCl solution, HCl vapor, and NH3 vapor. 

General Information


CAS Number 805246-78-0
Chemical Formula C45H30O3
Full Name 5''-(4'-Formyl-[1,1'-biphenyl]-4-yl)-[1,1':4',1'':3'',1''':4''',1''''-quinquephenyl]-4,4''''-dicarbaldehyde
Molecular Weight 618.72 g/mol
Synonyms TFBPB, TFBB, 1,3,5-Tris(4-formylbiphenyl)benzene
Classification / Family Quinquephenyls, Aldehydes, COF ligands

Chemical Structure


805246-78-0 - 5''-(4'-formyl-[1,1'-biphenyl]-4-yl)-[1,1':4',1'':3'',1''':4''',1''''-quinquephenyl]-4,4''''-dicarbaldehyde
5''-(4'-Formyl-[1,1'-biphenyl]-4-yl)-[1,1':4',1'':3'',1''':4''',1''''-quinquephenyl]-4,4''''-dicarbaldehyde (TFPBP) Chemical Structure, 805246-78-0

Product Details


Purity > 97%
Melting Point Tm = 158–160 °C
Appearance Off-white powder/crystals

MSDS Documentation


805246-78-0 - 5''-(4'-formyl-[1,1'-biphenyl]-4-yl)-[1,1':4',1'':3'',1''':4''',1''''-quinquephenyl]-4,4''''-dicarbaldehyde5''-(4'-Formyl-[1,1'-biphenyl]-4-yl)-[1,1':4',1'':3'',1''':4''',1''''-quinquephenyl]-4,4''''-dicarbaldehyde MSDS Sheet

Literature and Reviews


  1. Photoelectrochemical water splitting with a triazine based covalent organic framework, A. Pradhan et al., Sustainable Energy Fuels, 6, 4248-4255 (2022); DOI: 10.1039/D2SE00827K.
  2. A new triazine based π-conjugated mesoporous 2D covalent organic framework: its in vitro anticancer activities, S. Das et al., Chem. Commun., 54, 11475-11478 (2018); DOI: 10.1039/C8CC07289B.
  3. Tetrazine-Linked Covalent Organic Frameworks With Acid Sensing and Photocatalytic Activity, A. Zadehnazari et al., Adv. Mater., 2311042 (2023); DOI: 10.1002/adma.202311042.
Return to the top