FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on info@ossila.com, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.

4,4'-Biphenyldiacetonitrile

CAS Number 7255-83-6

Chemistry Building Blocks, COF Ligands, Materials, Porous Organic Frameworks


Product Code B3991-1g
Price $94 ex. VAT

Covalent Organic Frameworks (COFs) Biphenyl Ligand

An acetonitrile functionalised bridging ligand linker for COFs in application of visible light-induced hydrogen production and photocatalyst and biosensors


Specifications | MSDS | Literature and Reviews


4,4'-Biphenyldiacetonitrile, CAS number 7255-83-6, has a linear biphenyl linker with acetonitrile groups on both ends. 4,4'-Biphenyldiacetonitrile is commonly used in the preparation of microporous organic networks with aldehydes via the Knoevenagel condensation.

Prepared by the Knoevenagel condensation of tri(4-formylphenyl)amine with 4,4'-biphenyldiacetonitrile, visible light harvesting microporous COF showed visible light absorption in 400 – 530 nm and vivid emission at 542 nm. The COF/TiO2–Pt composite exhibited promising activity and enhanced stability as a photocatalytic system for visible light-induced hydrogen production from water.

Olefin-linked chiral CCOF 18 with 2D layered tetragonal structure was obtained by Knoevenagel polycondensation of chiral tetrabenzaldehyde of dibinaphthyl-22-crown-6 with 4,4′-biphenyldiacetonitrile. Reduction of the olefin linkage of CCOF-18 produced C–C single bond linked framework CCOF-18-R, while retaining high crystallinity and porosity as well as high chemical stability in both strong acids and bases.

MOF and COF ligands

MOF and COF ligands

Nitrile ligand for cross-linked COF networks

Worldwide shipping for 7255-83-6

Worldwide shipping

Quick and reliable shipping

High purity 7255-83-6

High purity

>98% High purity

Facile reactions

Facile reactions

Readily for Knoevenagel condensation reaction

General Information


CAS Number 7255-83-6
Chemical Formula C16H12N2
Full Name 4,4'-Biphenyldiacetonitrile
Molecular Weight 232.28 g/mol
Synonyms BPDAN, 2,2'-([1,1'-Biphenyl]-4,4'-diyl)diacetonitrile, 2-[4'-(cyanomethyl)-[1,1'-biphenyl]-4-yl]acetonitrile
Classification / Family Biphenyls, COF ligands, Acetonitriles

Chemical Structure


7255-83-6 - 4,4'-biphenyldiacetonitrile chemical structure
4,4'-Biphenyldiacetonitrile (BPDAN) Chemical Structure, 7255-83-6

Product Details


Purity >98%
Melting Point N/A
Appearance White to off-white powder/crystals

MSDS Documentation


7255-83-6 - 4,4'-biphenyldiacetonitrile4,4'-Biphenyldiacetonitrile MSDS Sheet

Literature and Reviews


  1. Microporous organic nanorods with electronic push–pull skeletons for visible light-induced hydrogen evolution from water, J. Park et al., J. Mater. Chem. A, 2, 7656-7661 (2014); DOi: 10.1039/C4TA00989D.
  2. Crystalline C—C and C═C Bond-Linked Chiral Covalent Organic Frameworks, C. yuan et al., J. Am. Chem. Soc., 143 (1), 369–381 (2021); DOI: 10.1021/jacs.0c11050.
  3. Macrocycle-Based Porous Organic Polymers for Separation, Sensing, and Catalysis, Z. Li et al., Adv. Mater., 34 (6), 2107401 (2022); DOI: 10.1002/adma.202107401.
Return to the top