FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on info@ossila.com, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.

1,2,4,5-Tetra((4-aminophenyl)ethynyl)benzene

CAS Number 2375652-88-1

Chemistry Building Blocks, COF Ligands, Materials, Monomers, Porous Organic Frameworks


Product Code B4021-250mg
Price $138 ex. VAT

Quality assured

Expert support

Volume discounts

Worldwide shipping

Fast and secure


Covalent Organic Frameworks (COFs) Tetraethynylbenzene Ligand

An amine functionalised bridging ligand linker for COFs in application of gas uptake and photocatalysts


1,2,4,5-Tetra((4-aminophenyl)ethynyl)benzene (TAEB) has a benzene core with four ethynyl bridges at 1,2,4,5-positions that are connecting four 4-aniline functional groups. 1,2,4,5-Tetra((4-aminophenyl)ethynyl)benzene is a cross-like highly symmetrical tecton that is commonly engaged in the construction of microporous covalent organic frameworks (COFs) via the peripheral amino functional groups to condense with aldehydes or acids to form imine or amide linkers.

1,2,4,5-Tetra((4-aminophenyl)ethynyl)benzene was prepared by reacting 4-ethynylaniline with 1,2,4,5-tetrabromobenzene via Sonogashira cross coupling reaction in the presence of Pd(PPh3)4 and copper iodide as catalysts.

MOF and COF ligands

MOF and COF ligands

Amine ligand for cross-linked COF/MOF networks

Worldwide shipping for 2375652-88-1

Worldwide shipping

Quick and reliable shipping

High purity 2375652-88-1

High purity

>98% High purity

Facile reactions

Facile reactions

Amine possesses excellent reactivity

General Information

CAS Number 2375652-88-1
Chemical Formula C38H26N4
Full Name 1,2,4,5-Tetra((4-aminophenyl)ethynyl)benzene
Molecular Weight 538.64 g/mol
Synonyms TAEB, 4,4',4'',4'''-(Benzene-1,2,4,5-tetrayltetrakis(ethyne-2,1-diyl))tetraaniline, 1,2,4,5-Tetrakis[2-(4-aminophenyl)ethynyl]benzene, 4,4',4''-((4'-Amino-[1,1'-biphenyl]-2,4,5-triyl)tris(ethyne-2,1-diyl))trianiline
Classification / Family Tetraethynylbenzene, COF ligands

Chemical Structure

2375652-88-1 - 1,2,4,5-tetra((4-aminophenyl)ethynyl)benzene chemical structure
1,2,4,5-Tetra((4-aminophenyl)ethynyl)benzene (TAEB) Chemical Structure, 2375652-88-1

Product Details

Purity >98%
Melting Point N/A
Appearance Green/Dark Yellow powder/crystals

MSDS Documentation

2375652-88-1 - 1,2,4,5-tetra((4-aminophenyl)ethynyl)benzene1,2,4,5-Tetra((4-aminophenyl)ethynyl)benzene MSDS Sheet

Literature and Reviews

  1. De Novo Design and Facile Synthesis of 2D Covalent Organic Frameworks: A Two-in-One Strategy, Y. Li et al., J. Am. Chem. Soc., 141, 35, 13822–13828 (2019); DOI: 10.1021/jacs.9b03463.
  2. An In Situ Film-to-Film Transformation Approach toward Highly Crystalline Covalent Organic Framework Films, Y. Lv et al., CCS Chem., 4 (5), 1519-1525 (2021); DOI: 10.31635/ccschem.021.202101025.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

Return to the top