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5'-(4-Formylphenyl)-2',4',6'-trimethyl-[1,1':3',1''-terphenyl]-4,4''-dicarbaldehyde

CAS Number 2195343-70-3

Carbaldehyde Monomers, Chemistry Building Blocks, COF Ligands, Materials, Monomers, Porous Organic Frameworks


Product Code B3911-1g
Price $119 ex. VAT

Covalent Organic Frameworks (COFs) Terphenyl Ligand

An aldehyde functionalised bridging ligand linker for COFs in application of fluorescence probe sensors, plant biology and detection of nitrofurantoin


Specifications | MSDS | Literature and Reviews


Triangular 5'-(4-Formylphenyl)-2',4',6'-trimethyl-[1,1':3',1''-terphenyl]-4,4''-dicarbaldehyde (TMTFPB), CAS number 2195343-70-3, has three methyl and three formylphenyl groups sitting on a benzene ring, alternating methyl and formylphenyl groups.

[(TTFB)4(ETTA)3]imine, termed COF-790, prepared from building blocks of 1,3,5-trimethyl-2,4,6-tris(4-formylphenyl)benzene (triangle) and 1,1,2,2-tetrakis(4-aminophenyl)ethene (square) into the fjh topology, exhibited permanent porosity and a high Brunauer–Emmett–Teller (BET) surface area of 2650 m2 g–1.

F-COF-2, also derived from  5’-(4-formylphenyl)-2’, 4’, 6’-trimethyl-[1, 1’: 3’, 1’-terphenyl]-4,4’’-dicarbaldehyde and 2,4,6-tristyryl s-triazine as the building block monomers, displayed combined skeleton and spatial rigidification endowed excellent fluorescence emission. F-COF-2 showed highly sensitive and selective nitrofurantoin (NFT) detection with a KSV value of 9.12 × 105 M–1, and limit of detection of 3.35 ppb.

MOF and COF ligands

MOF and COF ligands

Aldehyde ligand for cross-linked COF networks

Worldwide shipping for 2195343-70-3

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High purity 2195343-70-3

High purity

>98% High purity

Facile reactions

Facile reactions

Aldehyde possesses excellent reactivity

General Information


CAS Number 2195343-70-3
Chemical Formula C30H24O3
Full Name 5'-(4-Formylphenyl)-2',4',6'-trimethyl-[1,1':3',1''-terphenyl]-4,4''-dicarbaldehyde
Molecular Weight 432.51 g/mol
Synonyms TMTFPB, TTFB, 1,3,5-Trimethyl-2,4,6-tris(4-formylphenyl)benzene
Classification / Family Terphenyls, COF ligands

Chemical Structure


2195343-70-3 - 5'-(4-Formylphenyl)-2',4',6'-trimethyl-[1,1':3',1''-terphenyl]-4,4''-dicarbaldehyde chemical structure
5'-(4-Formylphenyl)-2',4',6'-trimethyl-[1,1':3',1''-terphenyl]-4,4''-dicarbaldehyde (TMTFPB) Chemical Structure, 2195343-70-3

Product Details


Purity >98%
Melting Point 247 – 248 °C
Appearance White to yellow to orange powder/crystals

MSDS Documentation


2195343-70-3 - 1,3,5-trimethyl-2,4,6-tris(4-formylphenyl)benzene5'-(4-Formylphenyl)-2',4',6'-trimethyl-[1,1':3',1''-terphenyl]-4,4''-dicarbaldehyde MSDS Sheet

Literature and Reviews


  1. Combined Skeleton and Spatial Rigidification of AIEgens in 2D Covalent Organic Frameworks for Boosted Fluorescence Emission and Sensing of Antibiotics, Y. Tang et al., ACS Appl. Mater. Interfaces, 14 (33), 37853–37864 (2022); DOI: 10.1021/acsami.2c11052.
  2. 3D Covalent Organic Frameworks Selectively Crystallized through Conformational Design, H. Nguyen et al., J. Am. Chem. Soc., 142 (48), 20335–20339 (2020); DOI: 10.1021/jacs.0c11064.
  3. Materials genomics methods for high-throughput construction of COFs and targeted synthesis, Y. Lan et al., Nat. Commun., 9, 5274 (2018); DOI: 10.1038/s41467-018-07720-x.
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