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Product Code B3331-2g
Price £33 ex. VAT

A fluorinated benzoic acid building block

Used as a synthesis intermediate for APIs

Specifications | MSDS | Literature and Reviews

2-Fluoro-6-methylbenzoic acid (CAS number 90259-27-1) is an ortho-benzoic acid with both methyl and fluoride substituents sitting at ortho-positions to the carboxylic acid. 2-Fluoro-6-methylbenzoic acid is involved in the synthesis of epidermal growth factor receptor (EGFR) inhibitor with potency of 340 nM. In the synthesis of the EGFR inhibitor, the methyl group of 2-fluoro-6-methylbenzoic acid undergoes radical bromination, enabling nucleophilic substitution to phthalimide. Subsequently, the carboxylic acid group is attached to the allosteric motif through an amination reaction to form the inhibitor.

2-Fluoro-6-methylbenzoic acid is also a key building block of avacopan which is used to treat anti-neutrophil cytoplasmic autoantibody-associated vasculitis.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated benzoic acid building block

Fluorinated benzoic acid building block

For drug discovery, medicinal chemistry, and biochemistry

competitively priced 90259-27-1

Low Cost

Competitively priced, high quality product

High purity 90259-27-1

High purity

>97% High purity

General Information

CAS Number 90259-27-1
Chemical Formula C8H7FO2
Full Name 2-Fluoro-6-methylbenzoic acid
Molecular Weight 154.14 g/mol
Synonyms 2-Carboxy-3-fluorotoluene, 6-Fluoro-o-toluic acid
Classification / Family Fluorinated building blocks, Benzoic acid building blocks, APIs

Chemical Structure

2-Fluoro-6-methylbenzoic acid chemical structure, CAS 90259-27-1
2-Fluoro-6-methylbenzoic acid chemical structure, CAS 90259-27-1

Product Details

Purity 97%
Melting Point Tm = 124 °C – 125 °C
Appearance White Powder

MSDS Documentation

2-Fluoro-6-methylbenzoic acid2-Fluoro-6-methylbenzoic acid MSDS Sheet

Literature and Reviews

  1. Avacopan. C5a anaphylatoxin chemotactic receptor 1 (C5aR1) antagonist, Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, J. Pease, Drugs of the Future, 46 (3), 183–190 (2021); DOI: 10.1358/dof.2021.46.3.3239643.
  2. Discovery of potent and selective PI3Kγ inhibitors, S. Drew et al., J. Med. Chem., 63, 11235–11257 (2020); DOI: 10.1021/acs.jmedchem.0c01203.
  3. Discovery of 3‑cyano‑N‑(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)‑1H‑pyrrolo[2,3‑b]pyridin-5-yl)benzamide: a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C2 inverse agonist, M. Schnute et al., J. Med. Chem., 61, 10415–10439 (2018); DOI: 10.1021/acs.jmedchem.8b00392.
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