2-Chloro-5-fluoronitrobenzene

CAS Number 345-17-5

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers, Non-Heterocyclic Building Blocks

2-Chloro-5-fluoronitrobenzene CAS 345-17-5

A fluorinated nitrobenzene building block

Utilised as a synthesis intermediate for APIs

Overview
Related Products

2-Chloro-5-fluoronitrobenzene (CAS number 345-17-5) is a benzene derivative with chloride, fluoride and nitro functional groups. 2-Chloro-5-fluoronitrobenzene is applied in the synthesis of active pharmaceutical ingredients (APIs), particularly benzothiazole derivatives. The synthesis of benzothiazole derivatives involves the use of 2-chloro-5-fluoronitrobenzene, methylacetophenone, and elemental sulphur as reagents.

2-Chloro-5-fluoronitrobenzene also finds its use in synthesising fluorophenylthio-benzylamine for the binding of serotonin transporters (SERT). The resulting molecule shows a high selective binding affinity to SERT over norepinephrine and dopamine transporters.

Multiple functional groups

For facile synthesis

Fluorinated nitrobenzene building block

For drug discovery, medicinal chemistry, and biochemistry

Low Cost

Competitively priced, high quality product

High purity

>98% High purity

General Information

CAS Number	345-17-5
Chemical Formula	C₆H₃ClFNO₂
Full Name	1-Chloro-4-fluoro-2-nitrobenzene
Molecular Weight	175.54 g/mol
Synonyms	1-Chloro-4-fluoronitrobenzene
Classification / Family	Fluorinated building blocks, Chlorinated building blocks, APIS, Benzothiazoles

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 37 °C – 39 °C
Appearance	Off-White Crystals

MSDS Documentation

2-Chloro-5-fluoronitrobenzene MSDS Sheet

Literature and Reviews

Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents, Y. Huang et al., J. Med. Chem., 48 (7), 2559–2570 (2005); DOI: 10.1021/jm0400808.
N,N-Dimethyl-2-(2-amino-4-¹⁸F-fluorophenylthio)-benzylamine (4-¹⁸F-ADAM): an improved PET radioligand for serotonin transporters, G. Shiue et al., J. Nucl. Med., 44 (12), 1890–1897 (2003); ISSN: 2159-662X.
Concise access to 2-aroylbenzothiazoles by redox condensation reaction between o-halonitrobenzenes, acetophenones, and elemental sulfur, T. Nguyen et al., Org. Lett., 17 (10), 2562–2565 (2015); DOI: 10.1021/acs.orglett.5b01182.

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