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Product Code B3251-2g
Price £45 ex. VAT

A fluorinated nitrobenzene building block

Utilised as a synthesis intermediate for APIs


Specifications | MSDS | Literature and Reviews


2-Chloro-5-fluoronitrobenzene (CAS number 345-17-5) is a benzene derivative with chloride, fluoride and nitro functional groups. 2-Chloro-5-fluoronitrobenzene is applied in the synthesis of active pharmaceutical ingredients (APIs), particularly benzothiazole derivatives. The synthesis of benzothiazole derivatives involves the use of 2-chloro-5-fluoronitrobenzene, methylacetophenone, and elemental sulphur as reagents.

2-Chloro-5-fluoronitrobenzene also finds its use in synthesising fluorophenylthio-benzylamine for the binding of serotonin transporters (SERT). The resulting molecule shows a high selective binding affinity to SERT over norepinephrine and dopamine transporters.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated nitrobenzene building block

Fluorinated nitrobenzene building block

For drug discovery, medicinal chemistry, and biochemistry

competitively priced 345-17-5

Low Cost

Competitively priced, high quality product

High purity 345-17-5

High purity

>98% High purity

General Information


CAS Number 345-17-5
Chemical Formula C6H3ClFNO2
Full Name 1-Chloro-4-fluoro-2-nitrobenzene
Molecular Weight 175.54 g/mol
Synonyms 1-Chloro-4-fluoronitrobenzene
Classification / Family Fluorinated building blocks, Chlorinated building blocks, APIS, Benzothiazoles

Chemical Structure


2-Chloro-5-fluoronitrobenzene chemical structure, CAS 345-17-5
2-Chloro-5-fluoronitrobenzene chemical structure, CAS 345-17-5

Product Details


Purity 98%
Melting Point Tm = 37 °C – 39 °C
Appearance Off-White Crystals

MSDS Documentation


2-Chloro-5-fluoronitrobenzene2-Chloro-5-fluoronitrobenzene MSDS Sheet

Literature and Reviews


  1. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents, Y. Huang et al., J. Med. Chem., 48 (7), 2559–2570 (2005); DOI: 10.1021/jm0400808.
  2. N,N-Dimethyl-2-(2-amino-4-18F-fluorophenylthio)-benzylamine (4-18F-ADAM): an improved PET radioligand for serotonin transporters, G. Shiue et al., J. Nucl. Med., 44 (12), 1890–1897 (2003); ISSN: 2159-662X.
  3. Concise access to 2-aroylbenzothiazoles by redox condensation reaction between o-halonitrobenzenes, acetophenones, and elemental sulfur, T. Nguyen et al., Org. Lett., 17 (10), 2562–2565 (2015); DOI: 10.1021/acs.orglett.5b01182.
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