FREE shipping to on qualifying orders when you spend or more, processed by Ossila BV. All prices ex. VAT. Qualifying orders ship free worldwide! Fast, secure, and backed by the Ossila guarantee. It looks like you are visiting from , click to shop in or change country. Orders to the EU are processed by our EU subsidiary.

It looks like you are using an unsupported browser. You can still place orders by emailing us on, but you may experience issues browsing our website. Please consider upgrading to a modern browser for better security and an improved browsing experience.

Product Code B1651-10g
Price £100 ex. VAT

A fluorinated heterocyclic building block

Used as a synthesis intermediate for ligands and bioactive ingredients in application of drug discovery and catalytic reactions

Specifications | MSDS | Literature and Reviews

3-(Trifluoromethyl)-2-pyridone (CAS number 22245-83-6), also known as 2-hydroxy-3-(trifluoromethyl)pyridine, is a trifluoromethyl substituted 2-hydroxypyridine. In catalytic reactions, the amide group of 2-pyridone binds to transition metals forming stable 5-/6-membred ring intermediates. Therefore, 3-(trifluoromethyl)-2-pyridone is extensively used as ligands in catalytic reaction such as directed C-H activation on meta-position. The trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.

Many derivatives of 2-pyridone are bioactive such as Doravirine a non-nucleoside reverse transcriptase inhibitor for treatment of AIDS. An imidazoline derivative containing 2-pyridone is evaluated as neuropeptide-Y receptor Y5 antagonists and it displays significant inhibition of food intake for treatment of diet-induced obesity.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated pyridone building block

For drug discovery, ligands, and organic synthesis

Worldwide shipping for 22245-83-6

Worldwide shipping

Quick and reliable shipping

High purity 22245-83-6

High purity

>97% High purity

General Information

CAS Number 22245-83-6
Chemical Formula C6H4F3NO
Full Name 2-Hydroxy-3-(trifluoromethyl)pyridine
Molecular Weight 163.10 g/mol
Synonyms 3-(Trifluoromethyl)pyridin-2-ol
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Ligands, Catalytic reactions, APIs

Chemical Structure

3-(Trifluoromethyl)-2-pyridone chemical structure, CAS 22245-83-6
3-(Trifluoromethyl)-2-pyridone chemical structure, CAS 22245-83-6

Product Details

Purity 97%
Melting Point Tm = 150 °C – 155 °C
Appearance Off-white to pale purple powder

MSDS Documentation

3-(Trifluoromethyl)-2-pyridone3-(Trifluoromethyl)-2-pyridone MSDS Sheet

Literature and Reviews

  1. De novo generation of a bright blue fluorophore from 2-oxoglutarate in biological samples, Y. Kim et al., Chem. Sci., 13, 365(2022); DOI: DOI: 10.1039/d1sc05808h.
  2. Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor, M. Ando et al., Bioorg. Med. Chem., 17, 6106–6122(2009); DOI: 10.1016/j.bmc.2009.05.069.
  3. Ligand-promoted meta-C-H functionalization of benzylamines, P. Wang et al., Angew. Chem. Int. Ed. Engl., 56(18), 5125–5129(2017); DOI: 10.1002/anie.201701803.
Return to the top