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Product Code B1651-10g
Price £100 ex. VAT

A fluorinated heterocyclic building block

Used as a synthesis intermediate for ligands and bioactive ingredients in application of drug discovery and catalytic reactions


Specifications | MSDS | Literature and Reviews


3-(Trifluoromethyl)-2-pyridone (CAS number 22245-83-6), also known as 2-hydroxy-3-(trifluoromethyl)pyridine, is a trifluoromethyl substituted 2-hydroxypyridine. In catalytic reactions, the amide group of 2-pyridone binds to transition metals forming stable 5-/6-membred ring intermediates. Therefore, 3-(trifluoromethyl)-2-pyridone is extensively used as ligands in catalytic reaction such as directed C-H activation on meta-position. The trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.

Many derivatives of 2-pyridone are bioactive such as Doravirine a non-nucleoside reverse transcriptase inhibitor for treatment of AIDS. An imidazoline derivative containing 2-pyridone is evaluated as neuropeptide-Y receptor Y5 antagonists and it displays significant inhibition of food intake for treatment of diet-induced obesity.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated pyridone building block

For drug discovery, ligands, and organic synthesis

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High purity 22245-83-6

High purity

>97% High purity

General Information


CAS Number 22245-83-6
Chemical Formula C6H4F3NO
Full Name 2-Hydroxy-3-(trifluoromethyl)pyridine
Molecular Weight 163.10 g/mol
Synonyms 3-(Trifluoromethyl)pyridin-2-ol
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Ligands, Catalytic reactions, APIs

Chemical Structure


3-(Trifluoromethyl)-2-pyridone chemical structure, CAS 22245-83-6
3-(Trifluoromethyl)-2-pyridone chemical structure, CAS 22245-83-6

Product Details


Purity 97%
Melting Point Tm = 150 °C – 155 °C
Appearance Off-white to pale purple powder

MSDS Documentation


3-(Trifluoromethyl)-2-pyridone3-(Trifluoromethyl)-2-pyridone MSDS Sheet

Literature and Reviews


  1. De novo generation of a bright blue fluorophore from 2-oxoglutarate in biological samples, Y. Kim et al., Chem. Sci., 13, 365(2022); DOI: DOI: 10.1039/d1sc05808h.
  2. Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor, M. Ando et al., Bioorg. Med. Chem., 17, 6106–6122(2009); DOI: 10.1016/j.bmc.2009.05.069.
  3. Ligand-promoted meta-C-H functionalization of benzylamines, P. Wang et al., Angew. Chem. Int. Ed. Engl., 56(18), 5125–5129(2017); DOI: 10.1002/anie.201701803.
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