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1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde

CAS Number 936940-82-8

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers


Product Code B2951-1g
Price £70 ex. VAT

A fluorinated phenylpyrazole building block

Used as a reaction intermediate for synthesising APIs


Specifications | MSDS | Literature and Reviews


1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde (CAS number 936940-82-8) is a pyrazole derivative substituted with a 3-fluorophenyl and an aldehyde group. Pyrazole derivatives are widely utilised as active pharmaceutical ingredients (APIs) including celecoxib. A novel anti-inflammatory pyrazole derivative, LQFM021, incorporates 1-(3-fluorophenyl)-1H-pyrazole-4-carbaldehyde in its synthesis. The entire synthesis process takes two steps: the functional group conversion of the aldehyde group to a nitrile and the formation of a tetrazole using sodium azide.

1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde is also employed in the synthesis of a pyrazole-based disubstituted urea, serving as an anti-melanoma agent.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated phenylpyrazole building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity

High purity

>98% High purity

General Information


CAS Number 936940-82-8
Chemical Formula C10H7FN2O
Full Name 1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde
Molecular Weight 190.17 g/mol
Synonyms N/A
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Aldehyde building blocks, APIs

Chemical Structure


1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde chemical structure, CAS 936940-82-8.
1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde chemical structure, CAS 936940-82-8

Product Details


Purity 98%
Melting Point N/A
Appearance Brown powder/crystals

MSDS Documentation


1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde MSDS Sheet

Literature and Reviews


  1. Modification, biological evaluation and SAR studies of novel 1H-pyrazole derivatives containing N,N'-disubstituted urea moiety as potential anti-melanoma agents, B.-F. Ruan et al., Chem. Biodiversity, 15, e1700504(2018); DOI: 10.1002/cbdv.201700504.
  2. In vitro genotoxicity and in vivo subchronic evaluation of the anti inflammatory pyrazole compound LQFM021, S. de Moura et al., Chem. Biol. Interact., 277, 185–194(2017); DOI: 10.1016/j.cbi.2017.09.004.
  3. Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole, SPJ, 19, 75–83(2011); DOI: 10.1016/j.jsps.2011.01.005.
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