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Product Code B3281-10g
Price $63 ex. VAT

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A fluorinated cinnamic acid building block

Used as a synthesis precursor for APIs


trans-3,4-Difluorocinnamic acid (CAS number 112897-97-9) is a difluoro-substituted benzene featuring a trans-propenoic acid. trans-3,4-Difluorocinnamic acid is readily used for the synthesis of substituted isoquinolones through Curtius rearrangement. Substituted isoquinolones are found to be effective 5-HT3 antagonists (infective dose ID50 of 0.35 μg/kg) in anticancer treatments.

trans-3,4-Difluorocinnamic acid is also utilized in the synthesis of psammaplin A derivatives as radiosensitizers for human lung cancer. The product derived from trans-3,4-difluorocinnamic acid demonstrates a potency of 16.14 μM.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated cinnamic acid building block

Fluorinated cinnamic acid building block

For drug discovery, medicinal chemistry, and biochemistry

competitively priced 112897-97-9

Low Cost

Competitively priced, high quality product

High purity 112897-97-9

High purity

>98% High purity

General Information

CAS Number 112897-97-9
Chemical Formula C9H6F2O2
Full Name (2E)-3-(3,4-Difluorophenyl)-prop-2-enoic acid
Molecular Weight 184.14 g/mol
Synonyms (2E)-3-(3,4-Difluorophenyl)acrylic acid
Classification / Family Fluorinated building blocks, Cinnamic acid building blocks, APIs

Chemical Structure

trans-3,4-Difluorocinnamic acid chemical structure, CAS 112897-97-9
trans-3,4-Difluorocinnamic acid chemical structure, CAS 112897-97-9

Product Details

Purity 98%
Melting Point Tm = 194 °C – 196 °C
Appearance White powder

MSDS Documentation

trans-3,4-Difluorocinnamic acidtrans-3,4-Difluorocinnamic acid MSDS Sheet

Literature and Reviews

  1. Synthesis of novel substituted isoquinolones, N. Briet et al., Tetrahedron, 58, 5761–2766 (2002); DOI: 10.1016/S0040-4020(02)00573-2.
  2. Harmicines — harmine and cinnamic acid hybrids as novel antiplasmodial hits, I. Perković et al., Eur. J. Med. Chem., 187, 111927 (2020); DOI: 10.1016/j.ejmech.2019.111927.
  3. Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli, Y. Katsuyama et al., Chem. Biol., 14, 613–621 (2007); DOI: 10.1016/j.chembiol.2007.05.004.
  4. Psammaplin A-modified novel radiosensitizers for human lung cancer and glioblastoma cellsC. Lee et al., J. Radiat. Prot. Res., 44 (1), 15–25 (2019); DOI: 10.14407/jrpr.2019.44.1.15.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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