trans-3,4-Difluorocinnamic acid

CAS Number 112897-97-9

Chemistry Building Blocks, Fluorinated Building Blocks, Non-Heterocyclic Building Blocks

trans-3,4-Difluorocinnamic acid CAS 112897-97-9

A fluorinated cinnamic acid building block

Used as a synthesis precursor for APIs

Overview
Related Products

trans-3,4-Difluorocinnamic acid (CAS number 112897-97-9) is a difluoro-substituted benzene featuring a trans-propenoic acid. trans-3,4-Difluorocinnamic acid is readily used for the synthesis of substituted isoquinolones through Curtius rearrangement. Substituted isoquinolones are found to be effective 5-HT₃ antagonists (infective dose ID₅₀ of 0.35 μg/kg) in anticancer treatments.

trans-3,4-Difluorocinnamic acid is also utilized in the synthesis of psammaplin A derivatives as radiosensitizers for human lung cancer. The product derived from trans-3,4-difluorocinnamic acid demonstrates a potency of 16.14 μM.

Multiple functional groups

For facile synthesis

Fluorinated cinnamic acid building block

For drug discovery, medicinal chemistry, and biochemistry

Low Cost

Competitively priced, high quality product

High purity

>98% High purity

General Information

CAS Number	112897-97-9
Chemical Formula	C₉H₆F₂O₂
Full Name	(2E)-3-(3,4-Difluorophenyl)-prop-2-enoic acid
Molecular Weight	184.14 g/mol
Synonyms	(2E)-3-(3,4-Difluorophenyl)acrylic acid
Classification / Family	Fluorinated building blocks, Cinnamic acid building blocks, APIs

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 194 °C – 196 °C
Appearance	White powder

MSDS Documentation

trans-3,4-Difluorocinnamic acid MSDS Sheet

Literature and Reviews

Synthesis of novel substituted isoquinolones, N. Briet et al., Tetrahedron, 58, 5761–2766 (2002); DOI: 10.1016/S0040-4020(02)00573-2.
Harmicines — harmine and cinnamic acid hybrids as novel antiplasmodial hits, I. Perković et al., Eur. J. Med. Chem., 187, 111927 (2020); DOI: 10.1016/j.ejmech.2019.111927.
Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli, Y. Katsuyama et al., Chem. Biol., 14, 613–621 (2007); DOI: 10.1016/j.chembiol.2007.05.004.
Psammaplin A-modified novel radiosensitizers for human lung cancer and glioblastoma cellsC. Lee et al., J. Radiat. Prot. Res., 44 (1), 15–25 (2019); DOI: 10.14407/jrpr.2019.44.1.15.

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