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Product Code B3431-5g
Price $44 ex. VAT

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A fluorinated o-phenylenediamine building block

For the synthesis of Schiff bases in applications of APIs and batteries


4-Fluoro-1,2-phenylenediamine (CAS number 367-31-7) is a fluorinated ortho-phenylenediamine. 4-Fluoro-1,2-phenylenediamine serves as a hardener for epoxy resins to enhance their thermal conductivity, thereby improving the thermal management of electrical motors and integrated circuits. The ortho-positioning of the amine groups enables 4-fluoro-1,2-phenylenediamine to form salen-type Schiff bases with salicylaldehydes. Such Schiff bases can coordinate to Co, Ni, Cu and Zn, affording corresponding organometallic complexes. The salen-type Schiff bases metal complexes show multiple applications, such as antimicrobial agents and redox carriers for flow batteries.

4-Fluoro-1,2-phenylenediamine is also utilized in the synthesis of 2,3-diaminophenazines through an oxidative reaction. 2,3-diaminophenazines have a wide range of applications in dyes and drug discovery.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated o-phenylenediamine building block

For drug discovery, Schiff bases, and battery research

competitively priced 367-31-7

Low Cost

Competitively priced, high quality product

High purity 367-31-7

High purity

>97% High purity

General Information

CAS Number 367-31-7
Chemical Formula C6H7FN2
Full Name 4-Fluoro-1,2-benzenediamine
Molecular Weight 126.13 g/mol
Synonyms 3,4-Diamino-1-fluorobenzene, 2-Amino-4-fluoroaniline, 4-Fluoro-o-phenylenediamine
Classification / Family Fluorinated building blocks, Phenylenediamine building blocks, Ligands, Schiff bases, Batteries, APIs

Chemical Structure

4-Fluoro-1,2-phenylenediamine chemical structure, CAS 367-31-7
4-Fluoro-1,2-phenylenediamine chemical structure, CAS 367-31-7

Product Details

Purity 97%
Melting Point Tm = 94 °C – 98 °C
Appearance Brown powder

MSDS Documentation

4-Fluoro-1,2-phenylenediamine4-Fluoro-1,2-phenylenediamine MSDS Sheet

Literature and Reviews

  1. Fluorinated 2,3-diaminophenazines: synthesis, mechanism of formation, and properties, J. Li et al., New J. Chem., 47, 19556–19568 (2023); DOI: 10.1039/D3NJ02875E.
  2. GreenMedChem: the challenge in the next decade toward eco-friendly compounds and processes in drug design, C. Castiello et al., Green Chem., 25, 2109 (2023); DOI: 10.1039/d2gc03772f.
  3. Effect of amine hardener molecular structure on the thermal conductivity of epoxy resins, G. Lv et al., ACS Appl. Polym. Mater., 3, 259–267 (2021); DOI: 10.1021/acsapm.0c01074.
  4. Expanding the potential of redox carriers for flow battery applications, A. Gabriel et al., J. Mater. Chem. A, 8, 17808–17816 (2020); DOI: 10.1039/D0TA04511J.
  5. Investigation on Co(II), Ni(II), Cu(II) and Zn(II) complexes derived from quadridentate salen-type Schiff base: structural characterization, DNA interactions, antioxidant proficiency and biological evaluation, G. Ramesh et al., Chem. Data Coll., 28, 100434 (2020); DOI: 10.1016/j.cdc.2020.100434.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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