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Product Code B2601-2g
Price $100 ex. VAT

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A fluorinated aminopyridine building block

Used as a precursor for bicyclic heterocycles and a building block for introducing a fluorinated pyridine moiety

2-Amino-3-fluoropyridine (CAS number 21717-95-3) is derived from pyridine having an amine and a fluorine at 2- and 3-positions. 2-Amino-3-fluoropyridine can be readily introduced to molecular scaffolds by reductive amination and nucleophilic substitution. The modification by 2-amino-3-fluoropyridine has shown a significant enhancement in antitumor activity, compared with the mother molecules. It is suggested that the 2-amino-3-fluoropyridine moiety forms a ππ interaction with the arginine residue in the protein sequence, leading to improved inhibitory.

Furthermore, 2-amino-3-fluoropyridine is also used to synthesise bicyclic heterocycles such as imidazopyridines for pharmaceutical active ingredients through Baylis-Hillman reaction.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated pyridine building block

For drug discovery, medicinal chemistry and biochemistry research

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High purity 21717-95-3

High purity

>98% High purity

General Information

CAS Number 21717-95-3
Chemical Formula C5H5FN2
Full Name 2-Amino-3-fluoropyridine
Molecular Weight 112.11 g/mol
Synonyms 3-Fluoro-2-pyridinamine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, APIs, Bicyclic heterocycles

Chemical Structure

2-Amino-3-fluoropyridine chemical structure, CAS 21717-95-3.
2-Amino-3-fluoropyridine chemical structure, CAS 21717-95-3

Product Details

Purity 98%
Melting Point Tm = 41 °C – 45 °C
Appearance White powder/chunks

MSDS Documentation

2-Amino-3-fluoropyridine2-Amino-3-fluoropyridine MSDS Sheet

Literature and Reviews

  1. Multicomponent approach for the synthesis of substituted 1,8-naphthyridine derivatives catalyzed by N-bromosulfonamides, R. Ghorbani-Vaghei et al., Synthesis, 49(04), 763–769(2017); DOI: 10.1055/s-0036-1588886.
  2. Identification of N-methyl nicotinamide and N-methyl pyridazine-3-carboxamide pseudokinase domain ligands as highly selective allosteric inhibitors of tyrosine kinase 2 (TYK2), R. Moslin et al., J. Med. Chem., 62(20), 8953–8972(2019); DOI: 10.1021/acs.jmedchem.9b00443.
  3. Studies on condensed-heterocyclic azolium cephalosporins I. Synthesis and antibacterial activity of 7β-[2-(2-aminothiazol-4-yl)-2(Z)-alkoxyiminoacetamido]-3-(imidazo[1,2-a]pyridinium-1-yl)methyl-3-cephem-4-carboxylates, T. Nishimura et al., J. Antibiot.,44(12), 1371–1393(1991); DOI: 10.7164/antibiotics.44.1371.
  4. Involvement of RPL11 in the enhancement of P53 stability by a podophyllum derivative, a topoisomerase II inhibitor, H. Wang et al., Cell Biol. Int., 42, 121–129(2018); DOI: 10.1002/cbin.10877
  5. Synthesis of imidazopyridines from the Morita-Baylis-Hillman acetates of nitroalkenes and convenient access to alpidem and zolpidem, D. Nair et al., Org. Lett., 14(17), 4580–4583(2012); DOI: 10.1021/ol3020418.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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