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Fluorinated Building Blocks

Fluorinated building blocks are chemical materials that contain halogen fluorine or fluorines normally to replace hydrogen or other halogenated atoms to form carbon fluoride (C-F) chemical bonds or as a source to provide negatively charged fluorine (F-). Fluorine is considered to have high electronegativity, small atomic radius and high polarizability with unique chemical, physical and biomedical properties. The benchmark polymer known as polytetrafluoroethylene (PTFE), industrially referred to as Teflon, is hyper-hydrophobic with all four hydrogens being replaced by fluorines in the repeating unit of polyethylene structure. PTFE is inert to most of chemicals including acids and bases with excellent electrical insulation and dielectric strength.

Fluorinated building blocks normally appear in mono-, double- or triple-hydrogen replaced forms as CF, CF2 or CF3 in chemical structures. With great electron-withdrawn ability and minimal steric perturbation, fluorinated building blocks, especially heterocyclic fluorinated building blocks are widely used for the synthesis of drugs such as anti‐inflammatory and anticancer agents. While comparing with the non-fluorinated anaesthetics, fluorinated ones are longer-lasting and almost insoluble in blood. It has been estimated that over 20% of the marketed drugs have been fluoro-pharmaceuticals. Herbicides and pesticides that contains fluorine in their chemical structures as agrochemicals show dramatic effect on the biological activity of agrochemicals such as herbicides, insecticides, fungicides, and plant growth.
2-Fluoro-4-hydroxybenzoic acid

2-Fluoro-4-hydroxybenzoic acid

From $113
3-Chloro-2-fluorobenzoic acid

3-Chloro-2-fluorobenzoic acid

From $94
2-Fluoro-3-methoxybenzaldehyde

2-Fluoro-3-methoxybenzaldehyde

From $172
3-Fluorobenzoic hydrazide

3-Fluorobenzoic hydrazide

From $125
2-Amino-5-fluorobenzonitrile

2-Amino-5-fluorobenzonitrile

From $100
4-Fluoro-2-methylphenol

4-Fluoro-2-methylphenol

From $75
2,4,5-Trifluorobenzonitrile

2,4,5-Trifluorobenzonitrile

From $100
4-Chloro-3-fluoroaniline

4-Chloro-3-fluoroaniline

From $63
2-Fluoro-4-nitroaniline

2-Fluoro-4-nitroaniline

From $88
3-Fluoro-2-methylbenzoic acid

3-Fluoro-2-methylbenzoic acid

From $113
2-Amino-6-fluorobenzonitrile

2-Amino-6-fluorobenzonitrile

From $113
3-Fluoro-p-anisidine

3-Fluoro-p-anisidine

From $113
3′-Fluoro-4′-methoxyacetophenone

3′-Fluoro-4′-methoxyacetophenone

Price $113
2-Bromo-4-fluorobenzonitrile

2-Bromo-4-fluorobenzonitrile

From $100
3-Fluoro-2-pyridinecarbonitrile

3-Fluoro-2-pyridinecarbonitrile

From $88
2-Amino-3-fluoropyridine

2-Amino-3-fluoropyridine

From $100
3-Fluoro-4-hydroxybenzaldehyde

3-Fluoro-4-hydroxybenzaldehyde

From $100
α,α-Difluorophenylacetic acid

α,α-Difluorophenylacetic acid

From $88
3,3-Difluoropiperidine hydrochloride

3,3-Difluoropiperidine hydrochloride

From $75
2,2-Difluorocyclopropanecarboxylic acid

2,2-Difluorocyclopropanecarboxylic acid

From $113
4-Fluoro-β-nitrostyrene

4-Fluoro-β-nitrostyrene

From $113
2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

From $113
2-Fluoro-4-(trifluoromethyl)aniline

2-Fluoro-4-(trifluoromethyl)aniline

From $113
N-Boc-4,4-difluoro-L-proline

N-Boc-4,4-difluoro-L-proline

From $88
3,4,5-Trifluorobenzoic acid

3,4,5-Trifluorobenzoic acid

From $113
2-Bromo-3′-fluoroacetophenone

2-Bromo-3′-fluoroacetophenone

From $145
4-Fluororesorcinol

4-Fluororesorcinol

From $88
3,4,5-Trifluoroaniline

3,4,5-Trifluoroaniline

From $69
4-Fluorobenzenesulfonamide

4-Fluorobenzenesulfonamide

From $82
2-Fluoro-5-nitrobenzoic acid

2-Fluoro-5-nitrobenzoic acid

From $82
1-Bis(4-fluorophenyl)methyl piperazine

1-Bis(4-fluorophenyl)methyl piperazine

From $100
3,5-Difluorobenzonitrile

3,5-Difluorobenzonitrile

From $82
6-Fluoronicotinic acid

6-Fluoronicotinic acid

From $95
2-Bromo-4-fluoropyridine

2-Bromo-4-fluoropyridine

From $157
3-Fluoro-2-hydroxybenzaldehyde

3-Fluoro-2-hydroxybenzaldehyde

From $138
2-Chloro-5-fluoropyrimidine

2-Chloro-5-fluoropyrimidine

From $125
2-Bromo-6-fluorobenzaldehyde

2-Bromo-6-fluorobenzaldehyde

From $125
2-Fluoro-5-nitrobenzonitrile

2-Fluoro-5-nitrobenzonitrile

From $90
Bis(4-fluorophenyl)methanol

Bis(4-fluorophenyl)methanol

From $132
N-Boc-trans-4-fluoro-L-proline

N-Boc-trans-4-fluoro-L-proline

From $95
(S)-(+)-3-Fluoropyrrolidine hydrochloride

(S)-(+)-3-Fluoropyrrolidine hydrochloride

From $100
Methyl pentafluorobenzoate

Methyl pentafluorobenzoate

From $95
5-Fluorosalicylic acid

5-Fluorosalicylic acid

From $138
(R)-(−)-3-Fluoropyrrolidine hydrochloride

(R)-(−)-3-Fluoropyrrolidine hydrochloride

From $90
4-Bromo-2,6-difluoroaniline

4-Bromo-2,6-difluoroaniline

From $95
2-Fluoroadenine

2-Fluoroadenine

From $113
3,3-Difluoropyrrolidine hydrochloride

3,3-Difluoropyrrolidine hydrochloride

From $138
4-Fluoro-3-nitrobenzoic acid

4-Fluoro-3-nitrobenzoic acid

From $83
2-Amino-4-fluorophenol

2-Amino-4-fluorophenol

From $70
2,4-Difluorobenzonitrile

2,4-Difluorobenzonitrile

From $83
2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone

2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone

From $125
4,4′-Bis(trifluoromethyl)-2,2′-bipyridine

4,4′-Bis(trifluoromethyl)-2,2′-bipyridine

From $125
5-Bromo-2-fluoropyridine

5-Bromo-2-fluoropyridine

From $132
1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone

1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone

From $113
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

From $100
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

From $144
3-Fluoro-4-morpholinoaniline

3-Fluoro-4-morpholinoaniline

From $125
Benzyl (3-Fluoro-4-morpholinophenyl)carbamate

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate

From $125
5-Fluoroisatin

5-Fluoroisatin

From $95
5-Fluorooxindole

5-Fluorooxindole

From $250
5-(Trifluoromethoxy)isatin

5-(Trifluoromethoxy)isatin

From $144
6-Fluoroindole-2-carboxylic acid

6-Fluoroindole-2-carboxylic acid

From $132
6-Fluoroindole

6-Fluoroindole

From $100
5-Fluoroindole

5-Fluoroindole

From $125
7-Fluoroindole

7-Fluoroindole

From $213
3-(4-Fluorophenyl)-1-isopropylindole

3-(4-Fluorophenyl)-1-isopropylindole

From $125
4-Fluoroindole

4-Fluoroindole

From $125
4-(Trifluoromethyl)-1H-imidazole

4-(Trifluoromethyl)-1H-imidazole

From $207
1-[2-(Trifluoromethyl)phenyl]imidazole

1-[2-(Trifluoromethyl)phenyl]imidazole

From $219
3-(Trifluoromethyl)-2-pyridone

3-(Trifluoromethyl)-2-pyridone

From $125
5-(Trifluoromethyl)-2-pyridone

5-(Trifluoromethyl)-2-pyridone

From $125
2-Furoyltrifluoroacetone

2-Furoyltrifluoroacetone

From $125
7-(Diethylamino)-4-(trifluoromethyl)coumarin

7-(Diethylamino)-4-(trifluoromethyl)coumarin

From $138
7-Hydroxy-4-(trifluoromethyl)coumarin

7-Hydroxy-4-(trifluoromethyl)coumarin

From $70
2-Fluoro-9H-carbazole

2-Fluoro-9H-carbazole

From $169
AB-TFMB

AB-TFMB

From $113
p-6FDAP

p-6FDAP

From $138
2,2'-Bis(trifluoromethyl)-4,4'-diaminodiphenyl ether (6FODA)

2,2'-Bis(trifluoromethyl)-4,4'-diaminodiphenyl ether (6FODA)

From $95
2,2-Bis[4-(4-aminophenoxy)phenyl]hexafluoropropane (4-BDAF)

2,2-Bis[4-(4-aminophenoxy)phenyl]hexafluoropropane (4-BDAF)

From $95
1,4-Bis(4-amino-2-trifluoromethylphenoxy)benzene (6FAPB)

1,4-Bis(4-amino-2-trifluoromethylphenoxy)benzene (6FAPB)

From $95
4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA)

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA)

From $113
2,2'-Bis(trifluoromethyl)benzidine (TFMB)

2,2'-Bis(trifluoromethyl)benzidine (TFMB)

From $95
2,2-Bis(3-amino-4-hydroxyphenyl)hexafluoropropane (6FAP)

2,2-Bis(3-amino-4-hydroxyphenyl)hexafluoropropane (6FAP)

From $95
2-(2,4-Difluorophenyl)-5-fluoropyridine

2-(2,4-Difluorophenyl)-5-fluoropyridine

From $132
2-(2,4-Difluorophenyl)-5-methylpyridine

2-(2,4-Difluorophenyl)-5-methylpyridine

From $163
4-Chloro-7-trifluoromethylquinoline-3-carboxylic acid ethyl ester

4-Chloro-7-trifluoromethylquinoline-3-carboxylic acid ethyl ester

From $182
4-Bromo-8-fluoroquinoline

4-Bromo-8-fluoroquinoline

From $169
6-Chloro-8-fluoroquinoline

6-Chloro-8-fluoroquinoline

From $100
8-Fluoro-4-hydroxy-2-methylquinoline

8-Fluoro-4-hydroxy-2-methylquinoline

From $119
(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone

(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone

From $182
2,4,6-Trifluoronitrobenzene

2,4,6-Trifluoronitrobenzene

From $93
Ethyl (4-fluorobenzoyl)acetate

Ethyl (4-fluorobenzoyl)acetate

From $138
5-Bromo-3-fluorosalicylaldehyde

5-Bromo-3-fluorosalicylaldehyde

From $138
6-Fluoro-4-chromanone

6-Fluoro-4-chromanone

From $150
2-(Difluoromethyl)benzimidazole

2-(Difluoromethyl)benzimidazole

From $144
3,3-Difluoroazetidine hydrochloride

3,3-Difluoroazetidine hydrochloride

Price $213
4-Fluoro-1H-indazole

4-Fluoro-1H-indazole

From $90
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

From $144
5,5'-Bis(trifluoromethyl)-2,2'-bipyridine

5,5'-Bis(trifluoromethyl)-2,2'-bipyridine

From $263
5,5'-dibromo-3,3'-difluoro-2,2'-bithiophene

5,5'-dibromo-3,3'-difluoro-2,2'-bithiophene

From $313
2-Bromo-6-fluoronaphthalene 

2-Bromo-6-fluoronaphthalene 

From $163
FIC

FIC

From $275
HDOQx-DBrDF

HDOQx-DBrDF

From $650
MeHDOQx-DBrDF

MeHDOQx-DBrDF

From $650
2FIC

2FIC

From $450
BDTT-F-Sn

BDTT-F-Sn

From $625
BDTTDSFSn

BDTTDSFSn

From $388
DFBTA-2ThBr-HD

DFBTA-2ThBr-HD

From $388
3,3'-Difluoro-5,5'-bis(trimethylstannyl)-2,2'-bithiophene

3,3'-Difluoro-5,5'-bis(trimethylstannyl)-2,2'-bithiophene

From $350
2-Ethylhexyl 4,6-dibromo-3-fluorothieno[3,4-b]thiophene-2-carboxylate

2-Ethylhexyl 4,6-dibromo-3-fluorothieno[3,4-b]thiophene-2-carboxylate

From $325
4,7-Dibromo-5,6-difluoro-2,1,3-benzothiadiazole

4,7-Dibromo-5,6-difluoro-2,1,3-benzothiadiazole

From $263
PCE11 Monomer

PCE11 Monomer

From $600
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