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Fluorinated Building Blocks

Containing fluorine to replace halogenated atoms, such as hydrogen, fluorinated building blocks form carbon-fluoride bonds or provide negatively charged fluorine.

Within our extensive range of fluorinated building blocks, you will find mono-, double-, or triple-hydrogen replaced polymers for a variety of applications.

Features and Applications

  • These compounds are desirable because fluorine has high electronegativity, a small atomic radius, and high polarizability, plus unique chemical, physical and biomedical properties.
  • With great electron-withdrawn ability and minimal steric perturbation, fluorinated building blocks are widely used for the synthesis of drugs such as anti‐inflammatory and anticancer agents.
  • Agrochemicals that contain fluorine in their chemical structures show dramatic effect on the biological activity of herbicides, insecticides, fungicides, and plant growth.

Browse Fluorinated Building Blocks

Related categories: chemistry building blocks, heterocyclic building blocks, non-heterocyclic building blocks, monomers, boronates, organotin compounds, dibromo monomers, carbaldehyde monomers, diamines and dianhydrides

Page 1 of 2

Potassium nonafluoro-1-butanesulfonate CAS 29420-49-3

Potassium nonafluoro-1-butanesulfonate

CAS 29420-49-3

From $68
2-Fluorobiphenyl CAS 321-60-8

2-Fluorobiphenyl

CAS 321-60-8

From $54
Pentafluorobenzoic acid CAS 602-94-8

Pentafluorobenzoic acid

CAS 602-94-8

From $41
2,4,5-Trifluorophenylacetic acid CAS 209995-38-0

2,4,5-Trifluorophenylacetic acid

CAS 209995-38-0

From $54
4-Fluoro-1,2-phenylenediamine CAS 367-31-7

4-Fluoro-1,2-phenylenediamine

CAS 367-31-7

From $48
5-Fluorobenzoxazole-2-thiol CAS 13451-78-0

5-Fluorobenzoxazole-2-thiol

CAS 13451-78-0

From $61
5-Bromo-3-fluoropyridine-2-carboxylic acid CAS 669066-91-5

5-Bromo-3-fluoropyridine-2-carboxylic acid

CAS 669066-91-5

From $75
7-Fluoro-4-hydroxycoumarin CAS 2145-27-9

7-Fluoro-4-hydroxycoumarin

CAS 2145-27-9

From $68
2-Amino-5-chloro-3-fluoropyridine CAS 246847-98-3

2-Amino-5-chloro-3-fluoropyridine

CAS 246847-98-3

From $54
5-Fluoro-2-methylbenzoic acid CAS 33184-16-6

5-Fluoro-2-methylbenzoic acid

CAS 33184-16-6

From $61
5-Bromo-4-fluoro-2-methylaniline CAS 627871-16-3

5-Bromo-4-fluoro-2-methylaniline

CAS 627871-16-3

From $81
3′-Bromo-4′-fluoroacetophenone CAS 1007-15-4

3′-Bromo-4′-fluoroacetophenone

CAS 1007-15-4

From $48
3-Fluoro-5-(trifluoromethyl)benzoic acid CAS 161622-05-5

3-Fluoro-5-(trifluoromethyl)benzoic acid

CAS 161622-05-5

From $41
5-Chloro-2-fluorobenzonitrile CAS 57381-34-7

5-Chloro-2-fluorobenzonitrile

CAS 57381-34-7

From $54
2-Fluoro-6-methylbenzoic acid CAS 90259-27-1

2-Fluoro-6-methylbenzoic acid

CAS 90259-27-1

From $45
4′-Fluoro-3′-nitroacetophenone CAS 400-93-1

4′-Fluoro-3′-nitroacetophenone

CAS 400-93-1

From $48
4-Fluoro-3-methylbenzoic acid CAS 403-15-6

4-Fluoro-3-methylbenzoic acid

CAS 403-15-6

From $68
1,3,5-Tris(3-fluoro-4-formylphenyl)benzene CAS 2088007-04-7

1,3,5-Tris(3-fluoro-4-formylphenyl)benzene

CAS 2088007-04-7

$108
From $54
5-Chloro-2-fluorobenzoic acid CAS 394-30-9

5-Chloro-2-fluorobenzoic acid

CAS 394-30-9

From $68
2-Fluoro-5-methylbenzoic acid CAS 321-12-0

2-Fluoro-5-methylbenzoic acid

CAS 321-12-0

From $68
trans-3,4-Difluorocinnamic acid CAS 112897-97-9

trans-3,4-Difluorocinnamic acid

CAS 112897-97-9

From $68
4-Fluoro-2-iodobenzoic acid CAS 56096-89-0

4-Fluoro-2-iodobenzoic acid

CAS 56096-89-0

From $48
3-Fluoro-4-iodopyridine CAS 22282-75-3

3-Fluoro-4-iodopyridine

CAS 22282-75-3

From $68
2-Chloro-5-fluoronitrobenzene CAS 345-17-5

2-Chloro-5-fluoronitrobenzene

CAS 345-17-5

From $61
4-Bromo-3-fluorobenzonitrile CAS 133059-44-6

4-Bromo-3-fluorobenzonitrile

CAS 133059-44-6

From $68
3-Bromo-5-fluorophenol CAS 433939-27-6

3-Bromo-5-fluorophenol

CAS 433939-27-6

From $45
4-Bromo-3-fluoroiodobenzene CAS 136434-77-0

4-Bromo-3-fluoroiodobenzene

CAS 136434-77-0

From $48
5-Difluoromethoxy-2-mercaptobenzimidazole CAS 97963-62-7

5-Difluoromethoxy-2-mercaptobenzimidazole

CAS 97963-62-7

From $88
6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline CAS 31009-34-4

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline

CAS 31009-34-4

From $129
4-Bromo-6-fluoroquinoline CAS 661463-17-8

4-Bromo-6-fluoroquinoline

CAS 661463-17-8

From $129
4-Amino-2-(trifluoromethyl)pyridine CAS 147149-98-2

4-Amino-2-(trifluoromethyl)pyridine

CAS 147149-98-2

From $68
1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde CAS 936940-82-8

1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde

CAS 936940-82-8

From $95
Methyl 6-fluoropyridine-2-carboxylate CAS 455-71-0

Methyl 6-fluoropyridine-2-carboxylate

CAS 455-71-0

From $115
4-Hydroxy-2-(trifluoromethyl)benzoic acid CAS 320-32-1

4-Hydroxy-2-(trifluoromethyl)benzoic acid

CAS 320-32-1

From $88
5-Bromo-2-fluoropyrimidine CAS 62802-38-4

5-Bromo-2-fluoropyrimidine

CAS 62802-38-4

From $81
3-Chloro-5-fluoroaniline CAS 4863-91-6

3-Chloro-5-fluoroaniline

CAS 4863-91-6

From $88
6-Fluoropyridine-2-carbonitrile CAS 3939-15-9

6-Fluoropyridine-2-carbonitrile

CAS 3939-15-9

From $108
4-Fluoro-4′-methoxybenzophenone CAS 345-89-1

4-Fluoro-4′-methoxybenzophenone

CAS 345-89-1

From $122
2,4,6-Trifluorophenylacetic acid CAS 209991-63-9

2,4,6-Trifluorophenylacetic acid

CAS 209991-63-9

From $122
2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid CAS 652-34-6

2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid

CAS 652-34-6

From $108
2-Fluoropyridine-3-carbonitrile CAS 3939-13-7

2-Fluoropyridine-3-carbonitrile

CAS 3939-13-7

From $122
2-Bromo-5-fluorobenzonitrile CAS 57381-39-2

2-Bromo-5-fluorobenzonitrile

CAS 57381-39-2

From $81
1-Bromo-2-chloro-4-fluorobenzene CAS 110407-59-5

1-Bromo-2-chloro-4-fluorobenzene

CAS 110407-59-5

From $95
2-Fluoro-4-(trifluoromethyl)benzoic acid CAS 115029-24-8

2-Fluoro-4-(trifluoromethyl)benzoic acid

CAS 115029-24-8

From $135
3-Fluoro-4-methoxybenzoic acid CAS 403-20-3

3-Fluoro-4-methoxybenzoic acid

CAS 403-20-3

From $122
4-Methoxy-3-(trifluoromethyl)aniline CAS 393-15-7

4-Methoxy-3-(trifluoromethyl)aniline

CAS 393-15-7

From $122
4-Fluoro-2-methylbenzonitrile CAS 147754-12-9

4-Fluoro-2-methylbenzonitrile

CAS 147754-12-9

From $122
3-Fluoro-4-(trifluoromethyl)benzoic acid CAS 115754-21-7

3-Fluoro-4-(trifluoromethyl)benzoic acid

CAS 115754-21-7

From $122
3,5-Difluoropyridine-2-carbonitrile CAS 298709-29-2

3,5-Difluoropyridine-2-carbonitrile

CAS 298709-29-2

From $122
5-Cyano-2-fluoropyridine CAS 3939-12-6

5-Cyano-2-fluoropyridine

CAS 3939-12-6

From $122
2,6-Difluorocinnamic aldehyde CAS 117338-43-9

2,6-Difluorocinnamic aldehyde

CAS 117338-43-9

From $122
2-Fluoro-4-hydroxybenzoic acid CAS 65145-13-3

2-Fluoro-4-hydroxybenzoic acid

CAS 65145-13-3

From $122
3-Chloro-2-fluorobenzoic acid CAS 161957-55-7

3-Chloro-2-fluorobenzoic acid

CAS 161957-55-7

From $102
2-Fluoro-3-methoxybenzaldehyde CAS 103438-88-6

2-Fluoro-3-methoxybenzaldehyde

CAS 103438-88-6

From $185
3-Fluorobenzoic hydrazide CAS 499-55-8

3-Fluorobenzoic hydrazide

CAS 499-55-8

From $135
2-Amino-5-fluorobenzonitrile CAS 61272-77-3

2-Amino-5-fluorobenzonitrile

CAS 61272-77-3

From $108
4-Fluoro-2-methylphenol CAS 452-72-2

4-Fluoro-2-methylphenol

CAS 452-72-2

From $81
2,4,5-Trifluorobenzonitrile CAS 98349-22-5

2,4,5-Trifluorobenzonitrile

CAS 98349-22-5

From $108
4-Chloro-3-fluoroaniline CAS 367-22-6

4-Chloro-3-fluoroaniline

CAS 367-22-6

From $68
2-Fluoro-4-nitroaniline CAS 369-35-7

2-Fluoro-4-nitroaniline

CAS 369-35-7

From $95
3-Fluoro-2-methylbenzoic acid CAS 699-90-1

3-Fluoro-2-methylbenzoic acid

CAS 699-90-1

From $122
2-Amino-6-fluorobenzonitrile CAS 77326-36-4

2-Amino-6-fluorobenzonitrile

CAS 77326-36-4

From $122
3-Fluoro-p-anisidine CAS 366-99-4

3-Fluoro-p-anisidine

CAS 366-99-4

From $122
3′-Fluoro-4′-methoxyacetophenone CAS 455-91-4

3′-Fluoro-4′-methoxyacetophenone

CAS 455-91-4

Price $122
2-Bromo-4-fluorobenzonitrile CAS 36282-26-5

2-Bromo-4-fluorobenzonitrile

CAS 36282-26-5

From $108
3-Fluoro-2-pyridinecarbonitrile CAS 97509-75-6

3-Fluoro-2-pyridinecarbonitrile

CAS 97509-75-6

From $95
2-Amino-3-fluoropyridine CAS 21717-95-3

2-Amino-3-fluoropyridine

CAS 21717-95-3

From $108
3-Fluoro-4-hydroxybenzaldehyde CAS 405-05-0

3-Fluoro-4-hydroxybenzaldehyde

CAS 405-05-0

From $108
α,α-Difluorophenylacetic acid CAS 360-03-2

α,α-Difluorophenylacetic acid

CAS 360-03-2

From $95
3,3-Difluoropiperidine hydrochloride CAS 496807-97-7

3,3-Difluoropiperidine hydrochloride

CAS 496807-97-7

From $81
2,2-Difluorocyclopropanecarboxylic acid CAS 107873-03-0

2,2-Difluorocyclopropanecarboxylic acid

CAS 107873-03-0

From $122
4-Fluoro-β-nitrostyrene CAS 706-08-1

4-Fluoro-β-nitrostyrene

CAS 706-08-1

From $122
2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile CAS 82671-02-1

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

CAS 82671-02-1

From $122
2-Fluoro-4-(trifluoromethyl)aniline CAS 69409-98-9

2-Fluoro-4-(trifluoromethyl)aniline

CAS 69409-98-9

From $122
N-Boc-4,4-difluoro-L-proline CAS 203866-15-3

N-Boc-4,4-difluoro-L-proline

CAS 203866-15-3

From $95
3,4,5-Trifluorobenzoic acid CAS 121602-93-5

3,4,5-Trifluorobenzoic acid

CAS 121602-93-5

From $122
2-Bromo-3′-fluoroacetophenone CAS 53631-18-8

2-Bromo-3′-fluoroacetophenone

CAS 53631-18-8

From $157
4-Fluororesorcinol CAS 103068-41-3

4-Fluororesorcinol

CAS 103068-41-3

From $95
3,4,5-Trifluoroaniline CAS 163733-96-8

3,4,5-Trifluoroaniline

CAS 163733-96-8

From $75
4-Fluorobenzenesulfonamide CAS 402-46-0

4-Fluorobenzenesulfonamide

CAS 402-46-0

From $88
2-Fluoro-5-nitrobenzoic acid CAS 7304-32-7

2-Fluoro-5-nitrobenzoic acid

CAS 7304-32-7

From $88
1-Bis(4-fluorophenyl)methyl piperazine CAS 27469-60-9

1-Bis(4-fluorophenyl)methyl piperazine

CAS 27469-60-9

From $108
3,5-Difluorobenzonitrile CAS 64248-63-1

3,5-Difluorobenzonitrile

CAS 64248-63-1

From $88
6-Fluoronicotinic acid CAS 403-45-2

6-Fluoronicotinic acid

CAS 403-45-2

From $103
2-Bromo-4-fluoropyridine CAS 357927-50-5

2-Bromo-4-fluoropyridine

CAS 357927-50-5

From $169
3-Fluoro-2-hydroxybenzaldehyde CAS 394-50-3

3-Fluoro-2-hydroxybenzaldehyde

CAS 394-50-3

From $149
2-Chloro-5-fluoropyrimidine CAS 62802-42-0

2-Chloro-5-fluoropyrimidine

CAS 62802-42-0

From $135
2-Bromo-6-fluorobenzaldehyde CAS 360575-28-6

2-Bromo-6-fluorobenzaldehyde

CAS 360575-28-6

From $135
2-Fluoro-5-nitrobenzonitrile CAS 17417-09-3

2-Fluoro-5-nitrobenzonitrile

CAS 17417-09-3

From $98
Bis(4-fluorophenyl)methanol CAS 365-24-2

Bis(4-fluorophenyl)methanol

CAS 365-24-2

From $142
N-Boc-trans-4-fluoro-L-proline CAS 203866-14-2

N-Boc-trans-4-fluoro-L-proline

CAS 203866-14-2

From $103
(S)-(+)-3-Fluoropyrrolidine hydrochloride CAS 136725-53-6

(S)-(+)-3-Fluoropyrrolidine hydrochloride

CAS 136725-53-6

From $108
Methyl pentafluorobenzoate CAS 36629-42-2

Methyl pentafluorobenzoate

CAS 36629-42-2

From $103
5-Fluorosalicylic acid CAS 345-16-4

5-Fluorosalicylic acid

CAS 345-16-4

From $149
(R)-(−)-3-Fluoropyrrolidine hydrochloride CAS 136725-55-8

(R)-(−)-3-Fluoropyrrolidine hydrochloride

CAS 136725-55-8

From $98
4-Bromo-2,6-difluoroaniline CAS 67567-26-4

4-Bromo-2,6-difluoroaniline

CAS 67567-26-4

From $103
2-Fluoroadenine CAS 700-49-2

2-Fluoroadenine

CAS 700-49-2

From $122
3,3-Difluoropyrrolidine hydrochloride CAS 163457-23-6

3,3-Difluoropyrrolidine hydrochloride

CAS 163457-23-6

From $149
4-Fluoro-3-nitrobenzoic acid CAS 453-71-4

4-Fluoro-3-nitrobenzoic acid

CAS 453-71-4

From $90
2-Amino-4-fluorophenol CAS 399-97-3

2-Amino-4-fluorophenol

CAS 399-97-3

From $76
2,4-Difluorobenzonitrile CAS 3939-09-1

2,4-Difluorobenzonitrile

CAS 3939-09-1

From $90
2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone CAS 86404-63-9

2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone

CAS 86404-63-9

From $135
4,4′-Bis(trifluoromethyl)-2,2′-bipyridine CAS 142946-79-0

4,4′-Bis(trifluoromethyl)-2,2′-bipyridine

CAS 142946-79-0

From $135
5-Bromo-2-fluoropyridine CAS 766-11-0

5-Bromo-2-fluoropyridine

CAS 766-11-0

From $142
1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone CAS 211108-50-8

1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone

CAS 211108-50-8

From $122
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride CAS 84163-13-3

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

CAS 84163-13-3

From $108
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid CAS 100361-18-0

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

CAS 100361-18-0

From $156
3-Fluoro-4-morpholinoaniline CAS 93246-53-8

3-Fluoro-4-morpholinoaniline

CAS 93246-53-8

From $135
Benzyl (3-Fluoro-4-morpholinophenyl)carbamate CAS 168828-81-7

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate

CAS 168828-81-7

From $135
5-Fluoroisatin CAS 443-69-6

5-Fluoroisatin

CAS 443-69-6

From $103
5-Fluorooxindole CAS 56341-41-4

5-Fluorooxindole

CAS 56341-41-4

From $270
5-(Trifluoromethoxy)isatin CAS 169037-23-4

5-(Trifluoromethoxy)isatin

CAS 169037-23-4

From $156
6-Fluoroindole-2-carboxylic acid CAS 3093-97-8

6-Fluoroindole-2-carboxylic acid

CAS 3093-97-8

From $142
6-Fluoroindole CAS 399-51-9

6-Fluoroindole

CAS 399-51-9

From $108
5-Fluoroindole CAS 399-52-0

5-Fluoroindole

CAS 399-52-0

From $135
7-Fluoroindole CAS 387-44-0

7-Fluoroindole

CAS 387-44-0

From $230
3-(4-Fluorophenyl)-1-isopropylindole CAS 93957-49-4

3-(4-Fluorophenyl)-1-isopropylindole

CAS 93957-49-4

From $135
4-Fluoroindole CAS 387-43-9

4-Fluoroindole

CAS 387-43-9

From $135
4-(Trifluoromethyl)-1H-imidazole CAS 3468-69-8

4-(Trifluoromethyl)-1H-imidazole

CAS 3468-69-8

From $223
1-[2-(Trifluoromethyl)phenyl]imidazole CAS 25371-96-4

1-[2-(Trifluoromethyl)phenyl]imidazole

CAS 25371-96-4

From $237
3-(Trifluoromethyl)-2-pyridone CAS 22245-83-6

3-(Trifluoromethyl)-2-pyridone

CAS 22245-83-6

From $135
5-(Trifluoromethyl)-2-pyridone CAS 33252-63-0

5-(Trifluoromethyl)-2-pyridone

CAS 33252-63-0

From $135
2-(Trifluoromethyl)thioxanthen-9-one CAS 1693-28-3

2-(Trifluoromethyl)thioxanthen-9-one

CAS 1693-28-3

Price $129
2-Furoyltrifluoroacetone CAS 326-90-9

2-Furoyltrifluoroacetone

CAS 326-90-9

From $135
7-(Diethylamino)-4-(trifluoromethyl)coumarin CAS 41934-47-8

7-(Diethylamino)-4-(trifluoromethyl)coumarin

CAS 41934-47-8

From $149
7-Hydroxy-4-(trifluoromethyl)coumarin CAS 575-03-1

7-Hydroxy-4-(trifluoromethyl)coumarin

CAS 575-03-1

From $76
2-Fluoro-9H-carbazole CAS 391-53-7

2-Fluoro-9H-carbazole

CAS 391-53-7

From $183
AB-TFMB CAS 1449757-11-2

AB-TFMB

CAS 1449757-11-2

From $122
Next

More on Fluorinated Building Blocks

PTFE

The benchmark compound, polytetrafluoroethylene (PTFE), is industrially referred to as Teflon. PTFE is hyper-hydrophobic as fluorine replaces all four hydrogens across the repeating structure. While being inert to most chemicals, including acids and bases, PTFE has excellent electrical insulation and dielectric strength.

Anaesthetics

Compared to non-fluorinated anaesthetics, fluorinated anaesthetics are longer-lasting and almost insoluble in blood. It is estimated that over 20% of marketed drugs are fluoro-pharmaceuticals.

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