ZIF-8

CAS Number 59061-53-9

Metal Organic Frameworks, Porous Organic Frameworks

A MOF with zeolite-like topology

with high surface area and rigid structure for gas separation, drug delivery and catalysis

Overview | Product Information | Related Products

Zeolitic imidazolate framework-8 (CAS number 59061-53-9), commonly known as ZIF-8, is a sub-class of metal organic frameworks (MOFs). ZIF-8 is composed of tetrahedrally coordinated zinc ions with 2-methylimidazole linkers, resembling the zeolite topologies. The strong Zn–N bonds allow ZIF-8 to withstand high temperatures of up to 550 °C under inert atmosphere. The rigid zeolitic network distributes strain evenly, maintaining its highly porous structure. The excellent thermal stability and porosity of ZIF-8 make it suitable for applications such as gas separation, drug delivery and catalysis.

ZIF-8 has shown great potential for olefin gas separation in industrial scale. A ZIF-8 membrane exhibits a C₃H₆/C₃H₈ selectivity of 172.1 with C₃H₆ permeance of 5.9×10⁻⁹ mol/m²·s·Pa and stability up to 6 bar.

ZIF-8 is an ideal candidate for drug delivery due to its low toxicity and good biocompatibility. Active pharmaceutical ingredients (APIs) can be loaded to ZIF-8 through the impregnation method. Subsequently, the release of APIs can be activated by single stimulus for controlled and targeted drug delivery.

Multiple applications

Water purification, drug delivery, gas separation and many more

Robust framework

High porosity, surface area and stability

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Low cost

Low cost metal organic frameworks

General Information

CAS Number	59061-53-9
Chemical Formula	C₈H₁₀N₄Zn
Full Name	Poly[bis(2-methyl-1H-imidazolato-κ²N¹,N³)zinc(II)]
Molecular Weight	227.58 g/mol
Synonyms	Zeolitic Imidazolate Framework-8, Zn(mIm)₂, 2-Methylimidazole zinc salt
Classification or Family	Metal organic frameworks, Zeolitic imidazolate frameworks, Porous organic frameworks,

Structure

Product Details

Particle Size	0.5 μm (D50)
Surface Area (BET)	1926 m²/g
Pore Size	0.4 – 1 nm
Appearance	White powder

MSDS Documentation

ZIF-8 MSDS Sheet

References

Supercritical ethane processing of ZIF-8 membranes towards pressure-resistant C₃H₆/C₃H₈ separation, K. Yu et al., Angew. Chem. Int. Ed., 64, e202422709 (2025); DOI: 10.1002/anie.202422709.
Curcumin-loaded ZIF-8 nanomaterials: exploring drug loading efficiency and biomedical performance, M. Rahman et al., ACS Omega, 10, 3067–3079 (2025), DOI: 10.1021/acsomega.4c09945.
Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy, Q. Wang et al., RSC Adv., 10, 37600 (2020); DOI: 10.1039/d0ra07950b.

Study of mixed matrix membranes within situ synthesized zeolite imidazolate frameworks (ZIF-8, ZIF-67) in polyethersulfone polymer for CO₂/CH₄ separation, RSC Adv., 14, 27074 (2024); DOI: 10.1039/d4ra04400b.
ZIF-8 metal–organic frameworks and their hybrid materials: emerging photocatalysts for energy and environmental applications, Dalton Trans., 54, 2681 (2025); DOI: 10.1039/d4dt02662d.
Crystal growth of ZIF-8, ZIF-67, and their mixed-metal derivatives, D. Saliba et al., J. Am. Chem. Soc., 140(5), 1812–1823 (2018); DOI: 10.1021/jacs.7b11589.
Matrimid mixed matrix hollow fiber membranes: influence of ZIF-8 filler over O₂/N₂ separation performance, D. González-Revuelta et al., ACS Omega, 10 (22), 22813–22824 (2025); DOI: 10.1021/acsomega.4c11696.

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