Biocompatible Polymer for Drug Encapsulation and Controlled Release
Control micelle size, drug loading, and release rate
Specifications | Pricing and Options | MSDS | Literature and Reviews
mPEG-PLLA is an amphiphilic diblock copolymer with a hydrophilic mPEG block and a hydrophobic PLLA block. The hydrophobic PLLA block self-assembles in water to direct mPEG-PLLA forming polymeric micelles with a hydrophilic mPEG shell and a hydrophobic PLLA core. The core/shell structure allows for drug encapsulation and controlled drug release with enhanced drug biocompatibility. The PEG shell prevents the immune system from recognizing and clearing the nanoparticle, allowing it to circulate longer. The PLLA core eventually hydrolyzes, slowly releasing the drug over time.
Biocompatible and biodegradable, both PEG and PLLA break down safely in the body. The molecular weights of both units can be adjusted to control micelle size, drug loading, and release rate.
Used for advanced drug delivery systems, mPEG-PLLA forms nanoparticles to encapsulate poorly soluble drugs for tumors or infected tissues, reducing side effects. It has also been used to create scaffolds for bone, cartilage, skin, and blood vessel regeneration due to PLLA's excellent biocompatibility and mechanical properties. Hydrogels made from mPEG-PLLA can act as medical barriers to prevent tissue adhesion after surgery.
General Information
| CAS Number | 709611-53-0 |
|---|---|
| Chemical Formula | CH3O(C2H4O)m(C3H4O2)nH |
| Synonyms | mPEG-b-PLLA, PLLA-mPEG, mPEG-PLLA Methoxy poly(ethylene glycol)-block-poly(L-lactide), Methoxy Poly(ethylene glycol)-block-poly(L-lactide) |
| Molecular Weight | M2578A1: mPEG (1K)-PLLA (116K); mPEG = 1,000; Mn = 76,459, Mw = 117,006, PDI = 1.53 |
| Intrinsic Viscosity [η] | 0.91 dL/g (30 °C in Chloroform ) |
| Specific Rotation | -156.11 ° |
| Solubility | Chloroform, chlorobenzene |
| Form | White powder |
| Storage | 2 – 8 °C |
| Classification or Family | Polylactide, Poly(ethylene glycol), Biodegradable polymers, Biocompatible polymers, Blockcopolymers |
Chemical Structure
Pricing
| Batch | Quantity | Price |
|---|---|---|
| M2578A1 | 1 g | £180 |
| M2578A1 | 5 g | £550 |
| M2578A1 | 10 g | £790 |
MSDS Documentation
mPEG-PLLA MSDS sheetLiterature and Reviews
- S. Surwase et al. (2017), Tailoring the properties of mPEG-PLLA nanoparticles for better encapsulation and tuned release of the hydrophilic anticancer drug, Drug Deliv. Transl. Res., 7(3):416-427; DOI: 10.1007/s13346-017-0372-9.
- Q. Li et al. (2024), Imperatorin-Loaded RH60/mPEG–PLLA Micelles for Reversing Tamoxifen Resistance in Breast Cancer, ACS Appl. Nano Mater., 7 (2), 1625–1635; DOI: 10.1021/acsanm.3c04185.
- A. Wang et al. (2023), Biomedical Metal–Organic Framework Materials: Perspectives and Challenges, Adv. Funct. Mater., 34 (43), 2308589; DOI: 10.1002/adfm.202308589.