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1,1':4',1'':4'',1'''-Quarterphenyl-3,3''',5,5'''-tetracarboxylic acid

CAS Number 921619-91-2

Chemistry Building Blocks, Materials, MOF Ligands, Porous Organic Frameworks

1,1':4',1'':4'',1'''-Quarterphenyl-3,3''',5,5'''-tetracarboxylic acid CAS 921619-91-2
Product Code B3101-500mg
Price £110 ex. VAT
£ GBP

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Metal Organic Frameworks (MOFs) Quarterphenyl Ligand

A rigid linear ligand linker for MOFs in applications of drug delivery and temperature-dependent luminescence

1,1':4',1'':4'',1'''-quaterphenyl-3,3''',5,5'''-tetracarboxylic acid (H4QPTC), CAS number 921619-91-2, is a linear quarterphenyl with two carboxylic acid groups at 3,5-positions of each end benzene rings.

MOF with the chemical formula (NH2(CH3)2[Zn3(L)2·3.5DMF]) (MOF-Zn-H4QPTC) (H4L = 1,1′,4′,1″,4″,1‴-quaterphenyl-3,5,3‴,5‴-tetracarboxylic acid) shows an unusual 4,8-connected 3D structure. The drug 5-fluorouracil (5-FU) uptake into the complex was about 22.5 wt.% per gram of dehydrated form of MOF-Zn-H4QPTC. 5-Fu is then released in a highly controlled and progressive fashion with 92% of the drug being released in 120 h.

Anionic MOF with In(III) centres and tetracarboxylic acid ligands (MOF-In-H4QPTC) shows kinetic trapping behaviour of hydrogen. With piperazinium dications in its pores, the framework exhibits hysteretic hydrogen adsorption. 

Ratiometric thermometer encapsulating luminescent perylene dye into the pores of a europium metal–organic framework (MOF-Eu-H4QPTC), exhibits highly temperature dependent luminescence intensity ratio over the physiological temperature range, with a maximum sensiti­vity of 1.28% °C−1 at 20 °C.

General Information

CAS Number 921619-91-2
Chemical Formula C28H18O8
Full Name 1,1':4',1'':4'',1'''-quaterphenyl-3,3''',5,5'''-tetracarboxylic acid
Molecular Weight 482.44 g/mol
Synonyms H4QPTC, Quarterphenyl-3,3''',5,5'''-tetracarboxylic acid
Classification / Family Quarterphenyl, MOF ligands, 

Chemical Structure

921619-91-2 - quarterphenyl-3,3''',5,5'''-tetracarboxylic acid chemical structure
1,1':4',1'':4'',1'''-quaterphenyl-3,3''',5,5'''-tetracarboxylic acid (H4QPTC) Chemical Structure, 921619-91-2

Product Details

Purity >98%
Melting Point n.a.
Appearance Off White powder/crystal

MSDS Documentation

921619-91-2 - 1,1':4',1'':4'',1'''-quaterphenyl-3,3''',5,5'''-tetracarboxylic acid1,1':4',1'':4'',1'''-Quaterphenyl-3,3''',5,5'''-tetracarboxylic acid MSDS Sheet

Literature and Reviews

  1. A new (4,8)-connected topological MOF as potential drug delivery, Q. Li et al., Inorg. Chem. Commun., 55, 8-10 (2015); DOI: 10.1016/j.inoche.2015.02.023.
  2. Loading Photochromic Molecules into a Luminescent Metal–Organic Framework for Information Anticounterfeiting, Z. Li et al., Angew. Chem., 131 (50), 18193-18199 (2019); DOI: 10.1002/ange.201910467.
  3. Cation-induced kinetic trapping and enhanced hydrogen adsorption in a modulated anionic metal–organic framework, S. Yang et al., Nat. Chem., 1, 487–493 (2009); DOi: 10.1038/nchem.333
  4. Our journey of developing dual-emitting metal-organic framework-based fluorescent sensors, T. Xia et al., ZAAC, 648 (9), e202100355 (2022); DOI: 10.1002/zaac.202100355.
  5. Energy Transfer in Metal–Organic Frameworks for Fluorescence Sensing, J. Wang et al., ACS Appl. Mater. Interfaces, 14 (8), 9970–9986 (2022); DOI: 10.1021/acsami.1c24759.
  6. Dual-Emitting MOF⊃Dye Composite for Ratiometric Temperature Sensing, Y. Cui et al., 27 (8), 1420-1425 (2015); DOI: 10.1002/adma.201404700.
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