Phenyl 1-hydroxy-2-naphthoate

CAS Number 132-54-7

Liquid Crystals, Materials, Optoelectronic Materials

Phenyl 1-hydroxy-2-naphthoate CAS 132-54-7

Phenyl 1-hydroxy-2-naphthoate, liquid crystal Intermediate

Intermediate for the synthesis of natural products and anti-carcinogenic compounds, liquid crystal intermediates.

Specifications | Pricing and Options | MSDS | Literature and Reviews

Phenyl 1-Hydroxy-2-naphthoate (PHN), CAS number 132-54-7, is a phenyl ester of 1-hydroxy-2-naphthoic acid. Hydroxynaphthoate derivatives are well known for their biological and medicinal properties. The 1-hydroxy-2-naphthoate moiety has been discovered in natural products such as the cytotoxic compounds 3-hydroxymollugin and 3-methoxymollugin. For their biological and medicinal properties, hydroxynaphthoates play an important role in drug discovery and they have been used as intermediates for the synthesis of the anti-carcinogenic compounds.

Research also shows that both methyl 1-hydroxy-2-naphthoate and ethyl 1,6-dihydroxy-2-naphthoate develop anti-inflammatory activity, while 1-hydroxy-2-naphthoic acid itself has been recognized as an antibacterial agent.

Monomer for drug discovery

1-hydroxy-2-naphthoate moiety has been discovered in natural products

Exhibiting solvatochromism

Attributed to the intramolecular proton transfer

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

Chemical Structure

Phenyl 1-Hydroxy-2-naphthoate (PHN), CAS# 132-54-7 — Chemical structure of Phenyl 1-hydroxy-2-naphthoate (PHN), CAS 132-54-7

General Information

CAS Number	132-54-7
Chemical Formula	C₁₇H₁₂O₃
Molecular Weight	264.28
Full Name	Phenyl 1-hydroxy-2-naphthoate
Synonyms	1-Hydroxy-2-naphthoic acid phenyl ester, 2-Phenoxycarbonyl-1-naphthol, Phenyl 1-hydroxy-2-naphthalate
Classification / Family	Hydroxynaphthoate derivatives, Anti-inflammatory activity, Antibacterial

Product Details

Purity	>98% (¹HNMR)
Form	Off-white powder/crystals
Melting Point	93.0 to 96.0 °C

Pricing

Batch	Quantity	Price
M2367A1	25 g	£125
M2367A1	50 g	£220
M2367A1	100 g	£340

MSDS Documentation

Phenyl 1-hydroxy-2-naphthoate MSDS Sheet

Literature and Reviews

Solvatochromism and intramolecular hydrogen-bonding assisted dipole moment of phenyl 1-hydroxy-2-naphthoate in the ground and excited states, I. Sıdır et al., J. Mol. Liq., 221, 972-985 (2016); DOI: 10.1016/j.molliq.2016.06.019.
Infrared Spectrum and UV-Induced Photochemistry of Matrix-Isolated Phenyl 1-Hydroxy-2-Naphthoate, I. Sıdır et al., Photochem., 1(1), 10-25 (2021); DOI: 10.3390/photochem1010002.
Crystal structure of phenyl 1-hydroxy-2-naphthoate, an unexpected product from an attempted aryl aryl coupling reaction, K Peters et al., Z. Kristallogr. Cryst. Mater., 210 (3), 210-211 (1995); DOI: 10.1524/zkri.1995.210.3.210.

An Experimental and Theoretical Investigation of the Photophysics of 1-Hydroxy-2-naphthoic Acid, H. Mishra et al., J. Phys. Chem. A, 109, 12, 2746–2754 (2005); DOI: 10.1021/jp0461091.
Photoinduced proton transfer in 3-hydroxy-2-naphthoic acid, H. Mishra et al., J. Photochem. Photobiol., 139 (1), 23-36 (2001); DOI: 10.1016/S1010-6030(00)00415-9.