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Phenyl 1-hydroxy-2-naphthoate

CAS Number 132-54-7

Liquid Crystals, Optoelectronic Materials


Product Code M2367A1-25g
Price $157 ex. VAT

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Phenyl 1-hydroxy-2-naphthoate, liquid crystal Intermediate

Intermediate for the synthesis of natural products and anti-carcinogenic compounds, liquid crystal intermediates.


Phenyl 1-Hydroxy-2-naphthoate (PHN) is a phenyl ester of 1-hydroxy-2-naphthoic acid. Hydroxynaphthoate derivatives are well known for their biological and medicinal properties. The 1-hydroxy-2-naphthoate moiety has been discovered in natural products such as the cytotoxic compounds 3-hydroxymollugin and 3-methoxymollugin. For their biological and medicinal properties, hydroxynaphthoates play an important role in drug discovery and they have been used as intermediates for the synthesis of the anti-carcinogenic compounds.

Research also shows that both methyl 1-hydroxy-2-naphthoate and ethyl 1,6-dihydroxy-2-naphthoate develop anti-inflammatory activity, while 1-hydroxy-2-naphthoic acid itself has been recognized as an antibacterial agent.

Monomer for drug discovery

Monomer for drug discovery

1-hydroxy-2-naphthoate moiety has been discovered in natural products

Exhibiting solvatochromism

Exhibiting solvatochromism

Attributed to the intramolecular proton transfer

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High purity

High purity

>98% High purity

Chemical Structure

Phenyl 1-Hydroxy-2-naphthoate (PHN), CAS# 132-54-7
Chemical structure of Phenyl 1-hydroxy-2-naphthoate (PHN), CAS 132-54-7

General Information

CAS Number 132-54-7
Chemical Formula C17H12O3
Molecular Weight 264.28
Full Name Phenyl 1-hydroxy-2-naphthoate
Synonyms 1-Hydroxy-2-naphthoic acid phenyl ester, 2-Phenoxycarbonyl-1-naphthol, Phenyl 1-hydroxy-2-naphthalate
Classification / Family Hydroxynaphthoate derivatives, Anti-inflammatory activity, Antibacterial

Product Details

Purity >98% (1HNMR)
Form Off-white powder/crystals
Melting Point 93.0 to 96.0 °C

MSDS Documentation

Phenyl 1-hydroxy-2-naphthoate MSDSPhenyl 1-hydroxy-2-naphthoate MSDS Sheet

Pricing

Batch Quantity Price
M2367A1 25 g £125
M2367A1 50 g £220
M2367A1 100 g £340

Literature and Reviews

  1. Solvatochromism and intramolecular hydrogen-bonding assisted dipole moment of phenyl 1-hydroxy-2-naphthoate in the ground and excited states, I. Sıdır et al., J. Mol. Liq., 221, 972-985 (2016); DOI: 10.1016/j.molliq.2016.06.019.
  2. Infrared Spectrum and UV-Induced Photochemistry of Matrix-Isolated Phenyl 1-Hydroxy-2-Naphthoate, I. Sıdır et al., Photochem., 1(1), 10-25 (2021); DOI: 10.3390/photochem1010002.
  3. Crystal structure of phenyl 1-hydroxy-2-naphthoate, an unexpected product from an attempted aryl aryl coupling reaction, K Peters et al., Z. Kristallogr. Cryst. Mater., 210 (3), 210-211 (1995); DOI: 10.1524/zkri.1995.210.3.210.
  4. An Experimental and Theoretical Investigation of the Photophysics of 1-Hydroxy-2-naphthoic Acid, H. Mishra et al., J. Phys. Chem. A, 109, 12, 2746–2754 (2005); DOI: 10.1021/jp0461091.
  5. Photoinduced proton transfer in 3-hydroxy-2-naphthoic acid, H. Mishra et al., J. Photochem. Photobiol., 139 (1), 23-36 (2001); DOI: 10.1016/S1010-6030(00)00415-9.

To the best of our knowledge the information provided here is accurate. The values provided are typical at the time of manufacture and may vary over time and from batch to batch. Products may have minor cosmetic differences (e.g. to the branding) compared to the photos on our website. All products are for laboratory and research and development use only.

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