Fullerenol C60

Fullerenes for Photovoltaics and Biotechnology, Materials

Hydroxylated Hydrophilic Fullerene for Electronics, Biomedicine and as Antioxidants

Hydroxyl fullerene, Polyhydroxylated fullerene, Water-soluble C60 fullerene, Fullerenol C60, 99.5% and 99.9% Purity

Fullerenol is a derivative of C60 fullerene with multiple hydroxyl functional groups on its surface. The surface modification of the hydrophobic C60 fullerene with hydroxyl function groups makes fullerene hydrophilic and soluble in polar solvents such as ethanol, DMSO or water. The solubility of fullerenol is dependent on the number of hydroxyl groups attached on the surface of the fullerene ball. Lower degree hydroxylated fullerenols with 10 - 12 hydroxyl groups are soluble in THF, DMF and DMSO, and the medium degree fullerenols with 16 – 24 hydroxyl groups dissolve in more polar solvents such as ethanol and water.

Fullerene acceptor

Water soluble fullerenes

Versatile applications

Water compatible applications

Worldwide shipping

Quick and reliable shipping

High purity

99.5% and 99.9% Solvent free

Fullerenol has a tendency to aggregate to form nanosized clusters with diameters of 10.7 - 102 nm. The hydroxyl (-OH) groups of the fullerenol is acidic and prone to hydrogen bonding interactions with other fullerenol molecules to form nanoclusters. In aqueous solution, depending on the pH value, fullerenol is more or less deprotonated and exists in the form of stable polyanion nanoparticles.

With great numbers of conjugated double bonds and low residing energy level of lowest unoccupied molecular orbitals (LUMO), fullerenes have been known as radical sponges due to their great ability to scavenge free radicals. For this reason, C60 fullerenol possesses a large radical and cytotoxic activity and it can act as a strong antioxidant.

General Information

CAS Number	n.a.
Chemical Formula	C₆₀(OH)_n
Synonyms	Hydroxyl fullerene, Polyhydroxylated fullerene, Water-soluble C60 fullerene, Fullerenol C60
Classification or Family	Fullerenes, Electron acceptors, Antioxidants

Product Details

Purity	99.5% (n = 30-50, C60 precursor >99.5%) 99.9% (Solvent free) (n= 30-50, C60 precursor >99.9%)
Solubility	> 100 mg/ml in H₂O (pH = 7, 25 °C),
Appearance	Yellow to light brown powder

Purity

99.5% (n = 30-50, C60 precursor >99.5%)

99.9% (Solvent free) (n= 30-50, C60 precursor >99.9%)

Solubility

> 100 mg/ml in H₂O (pH = 7, 25 °C),

Appearance

Yellow to light brown powder

Chemical Structure

MSDS Documentation

C60 Fullerenol MSDS Sheet

Learn More

Water-Soluble Fullerenes: Preparation and Applications

Water-soluble fullerenes, such as fullerenol C60, are either chemically modified, polymer grafted, or encapsulated in a hydrophillic agent. Fullerenes can then disperse or solubilize in aqueous media. Typical examples of water-soluble fullerenes are polyhydroxylated fullerenes, also knowns as fullerenols, polycarboxylated fullerenes and polysulfonated fullerenes.

References

A. Djordjevic et al. (2015); Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles, J. Nanomater., 567073; DOI: 0.1155/2015/567073.
S. Acquah et al. (2017); Review—The Beautiful Molecule: 30 Years of C60 and Its Derivatives, ECS J. Solid State Sci. Technol., 6, M3155; DOI 10.1149/2.0271706jss.
J. Grebowski et al. (2013); Fullerenols as a New Therapeutic Approach in Nanomedicine, BioMed Res. Interl., 751913; DOI: 10.1155/2013/751913.

S. Afreen et al. (2017); Hydration or hydroxylation: direct synthesis of fullerenol from pristine fullerene [C60] via acoustic cavitation in the presence of hydrogen peroxide, RSC Adv., 7, 31930-31939; DOI: 10.1039/C7RA03799F.
L. Tanzi et al. (2022); Synthesis and biological application of glyco- and peptide derivatives of fullerene C60, Eur. J. Med. Chem., 230, 114104; DOI: 10.1016/j.ejmech.2022.114104.
Y. Li et al. (2023); C60 Fullerenol to Stabilize and Activate Ru Nanoparticles for Highly Efficient Hydrogen Evolution Reaction in Alkaline Media, ACS Catal., 13 (11), 7597–7605; DOI: 10.1021/acscatal.3c01610.
Z. Wang et al. (2018); Mechanisms of Antioxidant Activities of Fullerenols from First-Principles Calculation, J. Phys. Chem. A, 122 (41), 8183-8190; DOI: 10.1021/acs.jpca.8b06340.
M. Seke et al. (2024); Versatile applications of fullerenol nanoparticles, Int. J. Pharm., 660, 124313; DOI: 10.1016/j.ijpharm.2024.124313.