5,5'-Dimethyl-2,2'-bipyridine
CAS Number 1762-34-1
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A frequent bipyridyl ligand and intermediate
Available for the synthesis of organometallic complexes, photosensitizers, and pharmaceuticals applications
5,5'-Dimethyl-2,2'-bipyridine (or 5,5'-Dimethyl-2,2'-bipyridyl), CAS number 1762-34-1, is a bipyridyl derivative with dimethyl functional groups at 5,5-positions. Dimethyl groups can be further oxidised to prepare 2,2'-bipyridine-5,5'-dicarboxylic acid. 5,5'-Dimethyl-2,2'-bipyridine is widely used as a ligand for organometallic chemical synthesis and pharmaceuticals applications.
Exhibiting high luminescence for G-quadruplex DNA, iridium(III) complex [Ir(pbi)2(5,5'-dmbpy)]PF6 is employed to construct G-quadruplex-based assay for protein tyrosine kinase-7 (PTK7) in aqueous solution. PTK7 is an important biomarker for a range of leukaemia and solid tumours. 5,5′-dimethyl -2, 2′-dipyridyl demonstrates significant activity against embryos and was capable of arresting development at a number of stages of embryogenesis.
General Information
CAS Number | 1762-34-1 |
Chemical Formula | C12H12N2 |
Full Name | 5,5′-Dimethyl-2,2′-bipyridine |
Molecular Weight | 184.24 g/mol |
Synonyms | 5,5'-Dimethyl-2,2'-bipyridyl, 5,5'-dmbpy |
Classification / Family | Bipyridine derivatives, Semiconductor synthesis intermediates, OLED, OFETs, organic photovoltaics |
Chemical Structure
Product Details
Purity | >98% (1H NMR) |
Melting Point | Tm = 115 °C |
Appearance | Off white powder |
MSDS Documentation
5,5'-Dimethyl-2,2'-bipyridine MSDS Sheet
Literature and Reviews
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Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe, Chem. Sci., 6, 4284-4290 (2015); DOI: 10.1039/C5SC01320H.
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A novel Au(III) complex with the 5,5′-dimethyl-2,2′-bipyridine ligand: Synthesis, characterization, X-ray crystal structure and biological evaluation, T. Kondori et al., Polyhedron, 210, 115513 (2021); 10.1016/j.poly.2021.115513.
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Supramolecular architectures of mononuclear nickel(II) and homobinuclear copper(II) complexes square with the 5,5’dimethyl-2,2’-bipyridine ligand: Syntheses, Crystal structures and Hirshfeld surface analyses, W. Maalej et al., J. Mol. Struct., 1250, 131727 (2022); DOI: 10.1016/j.molstruc.2021.131728.
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Assessment of the interaction procedure between Pt(IV) prodrug [Pt(5,5′-dmbpy)Cl4 and human serum albumin: Combination of spectroscopic and molecular modeling technique, S. Shahraki et al., J. Biomol. Struct. Dyn., 35 (14), 3098-3106 (2017); DOI: 10.1080/07391102.2016.1243074.
- Two new lead(II) coordination polymer and discrete complex containing bipyridine ligands with different positioned methyl substituents: synthesis, characterization, crystal structure determination, and luminescent properties, R. Alizadeh et al., Struct. Chem. 22, 1153–1163 (2011): DOI: 10.1007/s11224-011-9809-9.
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