4-(Trifluoromethyl)-2-pyridone

CAS Number 50650-59-4

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

4-(Trifluoromethyl)-2-pyridone CAS 50650-59-4

A highly electron deficient pyridone derivative

Used as building block for the synthesis of key intermediates in the production of pharmaceuticals and drug discovery

Overview
Related Products

4-(Trifluoromethyl)-2-pyridone (CAS number 50650-59-4), also known as 2-hydroxy-4-(trifluoromethyl)pyridine, bears the structure of 2-pyridone with an electron deficient trifluoromethyl group at 4-position of the pyridyl ring. 2-Pyridones are well-known organic compounds to form dimers via hydrogen bonding. 4-(Trifluoromethyl)-2-pyridone is a classic example that exists as tautomers, hence also known as 2-hydroxy-4-(trifluoromethyl)pyridine.

4-(Trifluoromethyl)-2-pyridinone, 2-Hydroxy-4-(trifluoromethyl)pyridine

The trifluoromethyl group is considered to be one of the most powerful electron withdrawing groups yet with a significant electronegativity between that of fluorine and chlorine. Pyridone is a well known inhibitor for serotonin uptake used to treat major depressive disorder.

Multiple functional groups

For facile synthesis

Fluorinated pyridone building block

For semiconductors, photocatalysts, and semiconductors

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	50650-59-4
Chemical Formula	C₆H₄F₃NO
Full Name	4-(Trifluoromethyl)-2-pyridone
Molecular Weight	163.10 g/mol
Synonyms	2-Hydroxy-4-(trifluoromethyl)pyridine, 4-(Trifluoromethyl)pyridin-2-ol
Classification / Family	Pyridone derivatives, Semiconductor synthesis intermediates, Organometallic compounds, Photocatalyst

Chemical Structure

Product Details

Purity	>98% (¹H NMR)
Melting Point	T_m = 158 °C
Appearance	White powder

MSDS Documentation

4-(Trifluoromethyl)-2-pyridone MSDS Sheet

Literature and Reviews

Evaluation of chemical compounds for induction of male sterility in wheat (Triticum aestivum L.), K. Hakrabortyet al., Euphytica 147, 329–335 (2006); DOI: 10.1007/s10681-005-9025-z.
Oxyfunctionalization of pyridine derivatives using whole cells of Burkholderia sp. MAK1, J. Stankevičiūtė et al., Sci. Rep. 6, 39129 (2016); DOI: 10.1038/srep39129.
Synthesis of Novel Analogues of Marine Indole Alkaloids: Mono(indolyl)-4-trifluoromethylpyridines and Bis(indolyl)-4-trifluoromethylpyridines as Potential Anticancer Agents, W. Xiong et al., Bioorg. Med. Chem., 9 (7), 1773-1780 (2001); DOI: 10.1016/S0968-0896(01)00070-0.
Convenient Approaches to 4-Trifluoromethylpyridine, B. Jiang et al., Org. Proc. Res. Dev., 5 (5), 531–534 (2001); DOI: 10.1021/op000109r.

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