3-Fluorobenzoic hydrazide

CAS Number 499-55-8

Chemistry Building Blocks, Fluorinated Building Blocks, Monomers, Non-Heterocyclic Building Blocks

A fluorinated benzoic hydrazide building block

Used as a synthesis intermediate for heterocyclic compounds

Overview
Related Products

3-Fluorobenzoic hydrazide (CAS number 499-55-8) is a hydrazide building block, derived from benzoic acid. Hydrazide derivatives are bioactive, for example isoniazid which is an antibiotic for tuberculosis. The hydrazide moiety in 3-fluorobenzoic hydrazide is nucleophilic and readily reacts with electrophiles, such as isothiocyanate derivatives. The resulting hydrazide-isothiocyanate products can undergo further cyclisation, forming triazole-thione derivatives. The triazole-thione derivatives synthesised in this manner show antimicrobial activity, with a minimum inhibitory concentration (MIC) of 62.5 µg/mL. Additionally, they have low toxicity against human cells. The heterocycles synthesised from 3-fluorobenzoic hydrazide allow for late-stage functionalisation, owing to their multiple functionalities.

Multiple functional groups

For facile synthesis

Fluorinated hydrazide building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	499-55-8
Chemical Formula	C₇H₇FN₂O
Full Name	3-Fluorobenzoic hydrazide
Molecular Weight	154.14 g/mol
Synonyms	3-Fluorobenzohydrazide, 3-Fluorobenzoic acid hydrazide, 3-Fluorobenzhydrazide
Classification / Family	Fluorinated building blocks, Hydrazide building blocks, Heterocycles, APIs

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 139 °C – 143 °C
Appearance	Off white to beige fibres

MSDS Documentation

3-Fluorobenzoic hydrazide MSDS Sheet

Literature and Reviews

Cyclization of 3-ethoxycarbonyliminocoumarin into benzopyrano[2,3-c]pyrazoles, N, Abid-Jarraya et al., J. Soc. Chim. Tunisie, 16, 75–81(2014); DOI:NA.
Synthesis, characterization and antimicrobial evaluation of some new Schiff, Mannich and acetylenic Mannich bases incorporating a 1,2,4-trazole nucleus, M. Aouad, Molecules, 19, 18897–18910(2014); DOI: 10.3390/molecules191118897.
Synthesis and biological evaluation of new Schiff bases derived from 4-amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione, S. Janowska et al., Molecules, 28, 2718(2023). DOI: 10.3390/molecules28062718.
Synthesis and antimicrobial activity of new Mannich bases with piperazine moiety, S. Janowska et al., Molecules, 28, 5562(2023); DOI: 10.3390/molecules28145562.

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