(S)-(+)-3-Fluoropyrrolidine hydrochloride

CAS Number 136725-53-6

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

(S)-(+)-3-Fluoropyrrolidine hydrochloride MSDS

(S)-(+)-3-Fluoropyrrolidine hydrochloride CAS 136725-53-6

A fluorinated S-chiral pyrrolidine

A synthesis building block or ligand for APIs and ferroelectrics.

Overview
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(S)-(+)-3-Fluoropyrrolidine hydrochloride (CAS number 136725-53-6) is a pyrrolidinium chloride salt with a fluorine substituent on the S-chiral carbon (3-position). The secondary amine in (S)-(+)-3-fluoropyrrolidine hydrochloride enables it to be used as a ligand for metal complexes. A cadmium-(S)-(+)-3-fluoropyrrolidine perovskite ferroelectric has Curie temperature (T_c) at 303 K, which is 63 K higher than those of non-substituted cadmium-pyrrolidine complexes. (S)-(+)-3-Fluoropyrrolidine hydrochloride extends the working temperature of ferroelectrics to room temperature.

(S)-(+)-3-Fluoropyrrolidine hydrochloride can be easily attached to molecular scaffolds through nucleophilic substitution. It is, therefore, used in preparing analogues of active pharmaceutical ingredients (APIs). An (S)-(+)-3-fluoropyrrolidine hydrochloride modified pyrazolopyridazine inhibitor of tyrosine regulated kinase showed pIC₅₀ (negative log of half maximal inhibitory concentration) of 6.73.

Multiple functional groups

For facile synthesis

Fluorinated S-pyrrolidine building block

For drug discovery, ferroelectrics and organic synthesis

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	136725-53-6
Chemical Formula	C₄H₉ClFN
Full Name	(S)-(+)-3-Fluoropyrrolidine hydrochloride
Molecular Weight	125.57 g/mol
Synonyms	(S)-(+)-3-Fluoropyrrolidine HCl, (3S)-3-Fluoropyrrolidine hydrochloride, (S)-3-Fluoropyrrolidine hydrochloride
Classification / Family	Fluorinated building block, Heterocyclic building block, Chiral building block, APIs, Ligands, Ferroelectrics

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 183 – 187 °C
Optical Rotation	8.88 ° (c = 1, methanol)
Appearance	Pink/beige powder

MSDS Documentation

(S)-(+)-3-Fluoropyrrolidine hydrochloride MSDS Sheet

Literature and Reviews

Discovery and characterization of selective and ligand-efficient DYRK inhibitors, S. Henderson et al., J. Med. Chem., 64, 11709−11728(2021); DOI: 10.1021/acs.jmedchem.1c01115.
Discovery of MK-8719, a potent o-GlcNAcase inhibitor as a potential treatment for tauopathies, H. Selnick et al., J. Med. Chem., 62, 10062−10097(2019); DOI: 10.1021/acs.jmedchem.9b01090.
H/F-substitution-induced homochirality for designing high-T_c molecular perovskite ferroelectrics, Y.-Y. Tang et al., Adv. Mater., 31(29), 1902163(2019); DOI: 10.1002/adma.201902163.
Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer–dimer interface, D. Carney et al., PNAS, 113(35), 9691−9698(2016); DOI: 10.1073/pnas.1611405113.
Urea derivatives of 2-aryl-benzothiazol-5-amines: a new class of potential drugs for human African trypanosomiasis, J. Med. Chem., 60(3), 957−971(2017); DOI: 10.1021/acs.jmedchem.6b01163.

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